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Sgta Gene Detail
Summary
  • Symbol
    Sgta
  • Name
    small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
  • Synonyms
    5330427H01Rik, D10Ertd190e, MGC:6336, Sgt
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098703
    NCBI Gene: 52551
  • Gene Overview
    MyGene.info: SGTA
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:81044075-81060181 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16107 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SGTA, small glutamine rich tetratricopeptide repeat containing alpha
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SGTA, small glutamine rich tetratricopeptide repeat containing alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    alphaSGT, hSGT, SGT
  • Links
    NCBI Gene ID: 6449
    neXtProt AC: NX_O43765
    UniProt: O43765

  • Chr Location
    19p13.3; chr19:2754714-2783356 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31122
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SGTA
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased neonatal death, subfertility, decreased body size, increased brain, intestine and heart weight, decreased serum insulin-like growth factor I level, large penis, and increased testis descent.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004937 Ensembl Gene Model | MGI Sequence Detail 16107 C57BL/6J ±  kb
    transcript ENSMUST00000005067 Ensembl | MGI Sequence Detail 1969 Not Applicable  
    polypeptide ENSMUSP00000005067 Ensembl | MGI Sequence Detail 315 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      48 from dbSNP Build 142
    Protein
    Information
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    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000014807 small glutamine-rich tetratricopeptide repeat-containing protein alpha
    • InterPro Domains
      IPR032374 SGTA, homodimerisation domain
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
      IPR001440 Tetratricopeptide repeat 1
      IPR013026 Tetratricopeptide repeat-containing domain
    Molecular
    Reagents
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    • All nucleic 159
      cDNA 158
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1915341, MGI:2143532
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 15
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:246066 Sundberg JP, et al., Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. PLoS One. 2017;12(7):e0180682

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory