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Tmc6 Gene Detail
Summary
  • Symbol
    Tmc6
  • Name
    transmembrane channel-like gene family 6
  • Synonyms
    D11Ertd204e, EVER1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098686
    NCBI Gene: 217353
  • Gene Overview
    MyGene.info: TMC6
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:117765985-117782193 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 82.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098686
protein coding gene Chr11:117765985-117782198 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019449
protein coding gene Chr11:122046791-122063141 (-)
A/J MGP_AJ_G0019417
protein coding gene Chr11:116635915-116652436 (-)
AKR/J MGP_AKRJ_G0019387
protein coding gene Chr11:120185267-120201565 (-)
BALB/cJ MGP_BALBcJ_G0019392
protein coding gene Chr11:117008400-117024584 (-)
C3H/HeJ MGP_C3HHeJ_G0019198
protein coding gene Chr11:120464381-120480678 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019841
protein coding gene Chr11:125767010-125783915 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017466
protein coding gene Chr11:113642429-113660702 (-)
CAST/EiJ MGP_CASTEiJ_G0018752
protein coding gene Chr11:121898817-121915036 (-)
CBA/J MGP_CBAJ_G0019169
protein coding gene Chr11:130725024-130742197 (-)
DBA/2J MGP_DBA2J_G0019281
protein coding gene Chr11:116036581-116052906 (-)
FVB/NJ MGP_FVBNJ_G0019273
protein coding gene Chr11:115656795-115673476 (-)
LP/J MGP_LPJ_G0019351
protein coding gene Chr11:122369678-122386031 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019306
protein coding gene Chr11:129688853-129705029 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019880
protein coding gene Chr11:120833033-120850131 (-)
PWK/PhJ MGP_PWKPhJ_G0018518
protein coding gene Chr11:117393703-117410119 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018310
protein coding gene Chr11:120563026-120582093 (-)
WSB/EiJ MGP_WSBEiJ_G0018804
protein coding gene Chr11:120803672-120819942 (-)



Homology
more
  • Human Ortholog
    TMC6, transmembrane channel like 6
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TMC6, transmembrane channel like 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EV1, EVER1, EVIN1, LAK-4P
  • Links
    NCBI Gene ID: 11322
    neXtProt AC: NX_Q7Z403
    UniProt: Q7Z403

  • Chr Location
    17q25.3; chr17:78108775-78132427 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human TMC6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 217353 NCBI Gene Model | MGI Sequence Detail 16209 C57BL/6J ±  kb
transcript NM_145439 RefSeq | MGI Sequence Detail 2945 C57BL/6  
polypeptide Q7TN60 UniProt | EBI | MGI Sequence Detail 810 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    9 Sequences
  • InterPro Domains
    IPR012496 TMC domain
    IPR038900 Transmembrane channel-like protein
Molecular
Reagents
less
  • All nucleic 84
    cDNA 83
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 32
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:209956 Liakath-Ali K, et al., Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen. Nat Commun. 2014;5:3540

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory