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Anapc4 Gene Detail
Summary
  • Symbol
    Anapc4
  • Name
    anaphase promoting complex subunit 4
  • Synonyms
    2610306D21Rik, APC4, D5Ertd249e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098673
    NCBI Gene: 52206
  • Gene Overview
    MyGene.info: ANAPC4
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:52834135-52866734 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 28.81 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    111 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098673
protein coding gene Chr5:52834012-52867797 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029550
protein coding gene Chr5:51835685-51873112 (+)
A/J MGP_AJ_G0029518
protein coding gene Chr5:50028577-50062640 (+)
AKR/J MGP_AKRJ_G0029466
protein coding gene Chr5:51719455-51757230 (+)
BALB/cJ MGP_BALBcJ_G0029527
protein coding gene Chr5:50502930-50536605 (+)
C3H/HeJ MGP_C3HHeJ_G0029250
protein coding gene Chr5:51880238-51916722 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029981
protein coding gene Chr5:53989283-54023860 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027221
protein coding gene Chr5:46787668-46822196 (+)
CAST/EiJ MGP_CASTEiJ_G0028658
protein coding gene Chr5:50889809-50926102 (+)
CBA/J MGP_CBAJ_G0029219
protein coding gene Chr5:55623700-55662884 (+)
DBA/2J MGP_DBA2J_G0029365
protein coding gene Chr5:50078374-50113882 (+)
FVB/NJ MGP_FVBNJ_G0029325
protein coding gene Chr5:49418742-49452293 (+)
LP/J MGP_LPJ_G0029450
protein coding gene Chr5:52301557-52349668 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029353
protein coding gene Chr5:56722087-56757652 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030014
protein coding gene Chr5:51207504-51243010 (+)
PWK/PhJ MGP_PWKPhJ_G0028382
protein coding gene Chr5:49146961-49181029 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028216
protein coding gene Chr5:50652161-50687350 (+)
WSB/EiJ MGP_WSBEiJ_G0028739
protein coding gene Chr5:51260347-51295103 (+)



Homology
more
  • Human Ortholog
    ANAPC4, anaphase promoting complex subunit 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ANAPC4, anaphase promoting complex subunit 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APC4
  • Links
    NCBI Gene ID: 29945
    neXtProt AC: NX_Q9UJX5
    UniProt: Q9UJX5

  • Chr Location
    4p15.2; chr4:25377226-25418498 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 52206 NCBI Gene Model | MGI Sequence Detail 32600 C57BL/6J ±  kb
    transcript NM_024213 RefSeq | MGI Sequence Detail 2668 C57BL/6  
    polypeptide Q91W96 UniProt | EBI | MGI Sequence Detail 807 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000004017 anaphase-promoting complex subunit 4
    • InterPro Domains
      IPR024789 Anaphase-promoting complex subunit 4
      IPR024790 Anaphase-promoting complex subunit 4 long domain
      IPR017169 Anaphase-promoting complex subunit 4, metazoa
      IPR024977 Anaphase-promoting complex subunit 4, WD40 domain
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 124
      cDNA 123
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1915174
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 25
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory