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Adam11
Gene Detail
 Symbol
Name
ID
Adam11
a disintegrin and metallopeptidase domain 11
MGI:1098667
Synonyms Mdc
Feature Type protein coding gene
Genetic Map
Chromosome 11
66.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:102761439-102780262 bp, + strand
From VEGA annotation of GRCm38

  18824 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7614  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Adam11

Human
homologs
Human Homolog ADAM11, ADAM metallopeptidase domain 11
NCBI Gene ID 4185
neXtProt AC  NX_O75078
Human Synonyms  MDC
Human Chr (Location)  17q21.3; chr17:44759037-44781846 (+)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted disruption of this gene are viable and overtly normal but show impaired hippocampus-dependent spatial learning and cerebellum-dependent motor coordination when tested using water maze and rotating rod tasks.
 
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process integrin-mediated signaling pathway, proteolysis
Component integral component of membrane, membrane
Function metalloendopeptidase activity, metallopeptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (337)    Tissues (182)    Images (36)
Theiler Stages: 15, 17, 19, 20, 22, 23, 24, 28
Assay TypeResults
RNA in situ 337
cDNA source data(32)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(37) cDNA(32) Primer pair(1) Other(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000002992 (Evidence)
Ensembl Gene ModelENSMUSG00000020926 (Evidence)
Entrez Gene11488 (Evidence)
UniGene89854
DFCITC1584704, TC1640472
DoTSDT.40166714, DT.94291801
NIA Mouse Gene IndexU043230
Consensus CDS ProjectCCDS25503.1, CCDS48946.1
International Mouse Knockout Project StatusAdam11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002992 VEGA Gene Model | MGI Sequence Detail 18824 C57BL/6J ±  kb
transcript OTTMUST00000006133 VEGA | MGI Sequence Detail 5102 Not Applicable 
polypeptide OTTMUSP00000002893 VEGA | MGI Sequence Detail 778 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(21) UniProt(3)
Polymorphisms PCR(1) : SNPs within 2kb(70 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006586 ADAM, cysteine-rich
InterPro IPR001762 Blood coagulation inhibitor, Disintegrin
InterPro IPR018358 Disintegrin, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
InterPro IPR002870 Peptidase M12B, propeptide
Protein Ontology PR:000003710 disintegrin and metalloproteinase domain-containing protein 11
References (Earliest) J:45793 Inoue D, et al., Cloning and initial characterization of mouse meltrin beta and analysis of the expression of four metalloprotease-disintegrins in bone cells. J Biol Chem. 1998 Feb 13;273(7):4180-7
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(36)
Other
accession IDs
MGI:2144492

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory