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Wasf2 Gene Detail
Summary
  • Symbol
    Wasf2
  • Name
    WAS protein family, member 2
  • Synonyms
    D4Ertd13e, WAVE2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098641
    NCBI Gene: 242687
  • Gene Overview
    MyGene.info: WASF2
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr4:133130505-133199756 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      69252 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 66.22 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    WASF2, WAS protein family member 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    WASF2, WAS protein family member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ393P12.2, IMD2, SCAR2, WASF4, WAVE2
  • Links
    NCBI Gene ID: 10163
    neXtProt AC: NX_Q9Y6W5
    UniProt: Q9Y6W5

  • Chr Location
    1p36.11; chr1:27404226-27490187 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 4 alleles in 4 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants show impaired embryonic development and do not survive to term. In addition to reduced embryo size, observed defects include hemorrhaging, abnormal somite development, perturbed angiogenesis, and shrunken cerebral ventricles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    26
  • Tissues
    23
  • cDNA Data
    156
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000010477 VEGA Gene Model | MGI Sequence Detail 69252 C57BL/6J ±  kb
    transcript OTTMUST00000024403 VEGA | MGI Sequence Detail 5642 Not Applicable  
    polypeptide OTTMUSP00000011229 VEGA | MGI Sequence Detail 497 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      791 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 158
      cDNA 156
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2140610
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 7
      Gene Ontology 12
      Phenotypes 17
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:260304 Roybal KT, et al., Computational spatiotemporal analysis identifies WAVE2 and cofilin as joint regulators of costimulation-mediated T cell actin dynamics. Sci Signal. 2016 Apr 19;9(424):rs3
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/12/2018
    MGI 6.12     		The Jackson Laboratory