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Wasf2 Gene Detail
Summary
  • Symbol
    Wasf2
  • Name
    WAS protein family, member 2
  • Synonyms
    D4Ertd13e, WAVE2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098641
    NCBI Gene: 242687
  • Gene Overview
    MyGene.info: WASF2
Location & Maps
more
  • Sequence Map
    Chr4:133130505-133199756 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      69252 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 66.22 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    WASF2, WAS protein family member 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    WASF2, WAS protein family member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ393P12.2, IMD2, SCAR2, WASF4, WAVE2
  • Links
    NCBI Gene ID: 10163
    neXtProt AC: NX_Q9Y6W5

  • Chr Location
    1p36.11; chr1:27404226-27490187 (-)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 4 alleles in 4 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    269
  • Chemically induced (other)
    2
  • Gene trapped
    261
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    4 involving Wasf2
  • Incidental Mutations
    APF
Homozygous mutants show impaired embryonic development and do not survive to term. In addition to reduced embryo size, observed defects include hemorrhaging, abnormal somite development, perturbed angiogenesis, and shrunken cerebral ventricles.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    30
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    26
  • Tissues
    23
  • cDNA Data
    156
  • Literature Summary
    7
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010477 VEGA Gene Model | MGI Sequence Detail 69252 C57BL/6J ±  kb
transcript OTTMUST00000024403 VEGA | MGI Sequence Detail 5642 Not Applicable  
polypeptide OTTMUSP00000011229 VEGA | MGI Sequence Detail 497 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    791 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000017373 Wiskott-Aldrich syndrome protein family member 2
  • InterPro Domains
    IPR028288 SCAR/WAVE family
    IPR003124 WH2 domain
Molecular
Reagents
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  • All nucleic 159
    cDNA 156
    Primer pair 2
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:2140610
References
more
  • Summaries
    All 56
    Developmental Gene Expression 7
    Gene Ontology 10
    Phenotypes 16
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:205441 Liang Y, et al., The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat Immunol. 2013 Aug;14(8):858-66
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory