Wasf2 MGI Mouse Gene Detail - MGI:1098641

Symbol

Wasf2
Name

WASP family, member 2
Synonyms

D4Ertd13e, WAVE2

Feature Type

protein coding gene
IDs

MGI:1098641
NCBI Gene: 242687
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr4:132857843-132927067 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 66.22 cM
Mapping Data

3 experiments

SNPs within 2kb

3216 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098641	protein coding gene	Chr4:132857816-132927067 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028886	protein coding gene	Chr4:135355621-135431604 (+)
A/J	MGP_AJ_G0028845	protein coding gene	Chr4:129699219-129769076 (+)
AKR/J	MGP_AKRJ_G0028798	protein coding gene	Chr4:133374581-133449082 (+)
BALB/cJ	MGP_BALBcJ_G0028868	protein coding gene	Chr4:130318991-130388970 (+)
C3H/HeJ	MGP_C3HHeJ_G0028582	protein coding gene	Chr4:133626597-133698576 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029310	protein coding gene	Chr4:140228490-140305175 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026581	protein coding gene	Chr4:122779239-122846308 (+)
CAST/EiJ	MGP_CASTEiJ_G0028015	protein coding gene	Chr4:131725141-131810485 (+)
CBA/J	MGP_CBAJ_G0028548	protein coding gene	Chr4:143871658-143959575 (+)
DBA/2J	MGP_DBA2J_G0028697	protein coding gene	Chr4:130119198-130188375 (+)
FVB/NJ	MGP_FVBNJ_G0028664	protein coding gene	Chr4:128990149-129061543 (+)
LP/J	MGP_LPJ_G0028798	protein coding gene	Chr4:135489030-135561107 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028690	protein coding gene	Chr4:148407481-148484838 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029348	protein coding gene	Chr4:133794259-133870654 (+)
PWK/PhJ	MGP_PWKPhJ_G0027736	protein coding gene	Chr4:126823557-126894514 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027562	protein coding gene	Chr4:129637015-129710526 (+)
WSB/EiJ	MGP_WSBEiJ_G0028095	protein coding gene	Chr4:133962169-134036375 (+)

Human Ortholog

WASF2, WASP family member 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WASF2, WASP family member 2
Synonyms

dJ393P12.2, IMD2, SCAR2, WASF4, WAVE2
Links

HGNC:12733

NCBI Gene ID: 10163

UniProt: Q9Y6W5
Chr Location

1p36.11; chr1:27404230-27490167 (-) GRCh38

MGI Vertebrate Homology

Wasf2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WASF2
Gene Tree

Wasf2

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Phenotype Summary

33 phenotypes from 5 alleles in 5 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

245
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

232
Radiation induced

1
Targeted

6
Genomic Mutations

4 involving Wasf2
Incidental Mutations

APF
Find Mice (IMSR)

120 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutants show impaired embryonic development and do not survive to term. In addition to reduced embryo size, observed defects include hemorrhaging, abnormal somite development, perturbed angiogenesis, and shrunken cerebral ventricles.

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All GO Annotations

61
GO References

20

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

742
Tissues

26
cDNA Data

157
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wasf2

ZFIN wasf2

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All Sequences

73
RefSeq

10
UniProt

6
CCDS

CCDS18742.1

Ensembl

ENSMUSG00000028868 (Evidence)
NCBI Gene

242687

			Length	Strain/Species	Flank
genomic	242687	NCBI Gene Model \| MGI Sequence Detail	69225	C57BL/6J	± kb
transcript	NM_001419443	RefSeq \| MGI Sequence Detail	5728	ZRU/MplStud
polypeptide	Q8BH43	UniProt \| EBI \| MGI Sequence Detail	497	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000017373 actin-binding protein WASF2

(term hierarchy)
InterPro Domains

IPR028288 SCAR/WAVE family

IPR003124 WH2 domain
GlyGen

Q8BH43 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 159

cDNA 157

Primer pair 2

Microarray probesets 2

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MGI:2140610

Summaries

All 88

Developmental Gene Expression 10

Gene Ontology 20

Phenotypes 23
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:354447 Zhang Y, et al., Neurodevelopmental disorder-associated CYFIP2 regulates membraneless organelles and eIF2alpha phosphorylation via protein interactors and actin cytoskeleton. Hum Mol Genet. 2024 Sep 19;33(19):1671-1687

TSS for Wasf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39452	Chr4:132857845-132857901 (+)	30 bp
Tssr39453	Chr4:132857924-132857947 (+)	93 bp
Tssr39454	Chr4:132857953-132857967 (+)	117 bp
Tssr39455	Chr4:132860171-132860178 (+)	2,332 bp
Tssr1326	Chr4:132900000-132900004 (+)	42,159 bp
Tssr39456	Chr4:132901782-132901786 (+)	43,941 bp
Tssr39457	Chr4:132901836-132901848 (+)	43,999 bp
Tssr39458	Chr4:132901850-132901883 (+)	44,024 bp
Tssr39459	Chr4:132903325-132903340 (+)	45,490 bp
Tssr39460	Chr4:132903647-132903672 (+)	45,817 bp
Tssr39461	Chr4:132912352-132912385 (+)	54,526 bp
Tssr39462	Chr4:132912932-132912958 (+)	55,102 bp
Tssr39463	Chr4:132912973-132913036 (+)	55,162 bp
Tssr39464	Chr4:132916447-132916471 (+)	58,616 bp
Tssr39465	Chr4:132919399-132919428 (+)	61,571 bp
Tssr39466	Chr4:132919498-132919520 (+)	61,666 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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