Wasf2 MGI Mouse Gene Detail - MGI:1098641 - WAS protein family, member 2

Wasf2 Gene Detail

Symbol

Wasf2
Name

WAS protein family, member 2
Synonyms

D4Ertd13e, WAVE2

Feature Type

protein coding gene
IDs

MGI:1098641
NCBI Gene: 242687
Gene Overview

MyGene.info: WASF2
Alliance

gene page

Sequence Map

Chr4:133130505-133199756 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

69252 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 66.22 cM
Mapping Data

3 experiments

Human Ortholog

WASF2, WAS protein family member 2

Vertebrate Orthologs

8

Human Ortholog

WASF2, WAS protein family member 2
Orthology source: HGNC, HomoloGene
Synonyms

dJ393P12.2, IMD2, SCAR2, WASF4, WAVE2
Links

HGNC:12733

NCBI Gene ID: 10163

neXtProt AC: NX_Q9Y6W5

UniProt: Q9Y6W5
Chr Location

1p36.11; chr1:27404226-27490187 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 86743
1 human;1 mouse;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: WASF2
Protein SuperFamily

Wiskott-Aldrich syndrome protein
Gene Tree

Wasf2

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Phenotype Summary

31 phenotypes from 4 alleles in 4 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

270
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

261
Radiation induced

1
Targeted

5
Genomic Mutations

4 involving Wasf2
Incidental Mutations

APF
Find Mice (IMSR)

102 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutants show impaired embryonic development and do not survive to term. In addition to reduced embryo size, observed defects include hemorrhaging, abnormal somite development, perturbed angiogenesis, and shrunken cerebral ventricles.

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All GO Annotations

35
GO References

14

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

32
Tissues

25
cDNA Data

157
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wasf2

ZFIN wasf2

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Wasf2 interacts with 351 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

63
RefSeq

8
UniProt

6
CCDS

CCDS18742.1
UniGene

23566

			Length	Strain/Species	Flank
genomic	OTTMUSG00000010477	VEGA Gene Model \| MGI Sequence Detail	69252	C57BL/6J	± kb
transcript	OTTMUST00000024403	VEGA \| MGI Sequence Detail	5642	Not Applicable
polypeptide	OTTMUSP00000011229	VEGA \| MGI Sequence Detail	497	Not Applicable

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SNPs within 2kb

791 from dbSNP Build 142

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UniProt

6 Sequences
Protein Ontology

PR:000017373 Wiskott-Aldrich syndrome protein family member 2

(term hierarchy)
InterPro Domains

IPR028288 SCAR/WAVE family

IPR003124 WH2 domain

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All nucleic 159

cDNA 157

Primer pair 2

Microarray probesets 2

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MGI:2140610

Summaries

All 71

Developmental Gene Expression 7

Gene Ontology 14

Phenotypes 17
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:263402 Bayes A, et al., Evolution of complexity in the zebrafish synapse proteome. Nat Commun. 2017 Mar 2;8:14613

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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