Wasf2
Gene Detail

Symbol Name ID

Wasf2 WAS protein family, member 2 MGI:1098641

Synonyms

D4Ertd13e, WAVE2

Feature Type

protein coding gene

Genetic Map

Chromosome 4

66.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:133130505-133199756 bp, + strand From VEGA annotation of GRCm38   69252 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:86743  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Wiskott-Aldrich syndrome protein
Gene Tree: Wasf2

Human homologs

Human Homolog		WASF2, WAS protein family, member 2
NCBI Gene ID		10163
neXtProt AC		NX_Q9Y6W5
Human Synonyms		dJ393P12.2, IMD2, SCAR2, WASF4, WAVE2
Human Chr (Location)		1p36.11; chr1:27404230-27490167 (-)  GRCh38

Alleles and phenotypes

All alleles(265) : Gene trapped(261) Targeted(4)
Incidental mutations (data from APF )
 

Homozygous mutants show impaired embryonic development and do not survive to term. In addition to reduced embryo size, observed defects include hemorrhaging, abnormal somite development, perturbed angiogenesis, and shrunken cerebral ventricles.

 

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	actin cytoskeleton organization, actin filament-based movement, ...
Component	cell-cell junction, cytoplasm, ...
Function	actin binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)

Data Summary: Results (18)    Tissues (17)    Images (5)
Theiler Stages: 10, 15, 18, 23, 25, 28

Assay Type	Results
Immunohistochemistry	4
Western blot	2
RT-PCR	12

cDNA source data(156)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(159) cDNA(156) Primer pair(2) Other(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000010477 (Evidence)
Ensembl Gene Model	ENSMUSG00000028868 (Evidence)
Entrez Gene	242687 (Evidence)
UniGene	23566
DoTS	DT.101385311, DT.110790400, DT.494498, DT.91293659
NIA Mouse Gene Index	U004913
Consensus CDS Project	CCDS18742.1
International Mouse Knockout Project Status	Wasf2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010477	VEGA Gene Model | MGI Sequence Detail	69252	C57BL/6J
transcript	OTTMUST00000024403	VEGA | MGI Sequence Detail	5642	Not Applicable
polypeptide	OTTMUSP00000011229	VEGA | MGI Sequence Detail	497	Not Applicable

All sequences(69) RefSeq(8) UniProt(6)

Polymorphisms

SNPs within 2kb(806 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR003124	WH2 domain
Protein Ontology	PR:000017373	Wiskott-Aldrich syndrome protein family member 2

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:205441 Liang Y, et al., The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat Immunol. 2013 Aug;14(8):858-66
All references(60)

Other accession IDs

MGI:2140610