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Hes2 Gene Detail
Summary
  • Symbol
    Hes2
  • Name
    hairy and enhancer of split 2 (Drosophila)
  • Synonyms
    HES-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098624
    NCBI Gene: 15206
Location & Maps
more
  • Sequence Map
    Chr4:152158867-152162469 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3603 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 82.92 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    HES2, hes family bHLH transcription factor 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HES2, hes family bHLH transcription factor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bHLHb40
  • Links
    NCBI Gene ID: 54626
    neXtProt AC: NX_Q9Y543

  • Chr Location
    1p36.31; chr1:6415232-6424664 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 22455
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: HES2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    5
  • Targeted
    5
  • Genomic Mutations
    3 involving Hes2
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010304 VEGA Gene Model | MGI Sequence Detail 3603 C57BL/6J ±  kb
transcript OTTMUST00000023991 VEGA | MGI Sequence Detail 2521 Not Applicable  
polypeptide OTTMUSP00000011001 VEGA | MGI Sequence Detail 157 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    32 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000008516 transcription factor HES-2
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR003650 Orange domain
Molecular
Reagents
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  • All nucleic 16
    Genomic 2
    cDNA 11
    Primer pair 3

    Microarray probesets 3
References
more
  • Summaries
    All 41
    Developmental Gene Expression 11
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:43727 Ishibashi M, et al., Molecular characterization of HES-2, a mammalian helix-loop-helix factor structurally related to Drosophila hairy and Enhancer of split. Eur J Biochem. 1993 Aug 1;215(3):645-52
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory