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Rif1 Gene Detail
Summary
  • Symbol
    Rif1
  • Name
    Rap1 interacting factor 1 homolog (yeast)
  • Synonyms
    5730435J01Rik, 6530403D07Rik, D2Ertd145e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098622
    NCBI Gene: 51869
Location & Maps
more
  • Sequence Map
    Chr2:52072842-52122383 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      49542 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RIF1, replication timing regulatory factor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RIF1, replication timing regulatory factor 1
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 55183
    neXtProt AC: NX_Q5UIP0

  • Chr Location
    2q23.3; chr2:151409883-151534202 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 6 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    77
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    70
  • Targeted
    5
  • Genomic Mutations
    1 involving Rif1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit embryonic lethality. Mice homozygous for a gene trap allele exhibit embryonic and postnatal lethality, reduced fertility, and decreased cell proliferation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012437 VEGA Gene Model | MGI Sequence Detail 49542 C57BL/6J ±  kb
transcript OTTMUST00000029579 VEGA | MGI Sequence Detail 8497 Not Applicable  
polypeptide OTTMUSP00000013312 VEGA | MGI Sequence Detail 2426 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    282 from dbSNP Build 137
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000014000 telomere-associated protein RIF1
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR028566 Telomere-associated protein Rif1
    IPR022031 Telomere-associated protein Rif1, N-terminal
Molecular
Reagents
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  • All nucleic 24
    cDNA 21
    Primer pair 3

    Microarray probesets 8
Other
Accession IDs
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MGI:1922959, MGI:1923494, MGI:2139159, MGI:2139383
References
more
  • Summaries
    All 53
    Developmental Gene Expression 7
    Gene Ontology 7
    Phenotypes 17
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:213416 Dan J, et al., Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. Dev Cell. 2014 Apr 14;29(1):7-19

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory