About   Help   FAQ
Rif1 Gene Detail
Summary
  • Symbol
    Rif1
  • Name
    replication timing regulatory factor 1
  • Synonyms
    5730435J01Rik, 6530403D07Rik, D2Ertd145e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098622
    NCBI Gene: 51869
  • Gene Overview
    MyGene.info: RIF1
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:52072832-52122383 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 29.98 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    291 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098622
protein coding gene Chr2:52072811-52126769 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025732
protein coding gene Chr2:51386456-51443307 (+)
A/J MGP_AJ_G0025708
protein coding gene Chr2:49404853-49457774 (+)
AKR/J MGP_AKRJ_G0025678
protein coding gene Chr2:50831733-50881606 (+)
BALB/cJ MGP_BALBcJ_G0025703
protein coding gene Chr2:49500824-49551997 (+)
C3H/HeJ MGP_C3HHeJ_G0025464
protein coding gene Chr2:50828475-50882707 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026149
protein coding gene Chr2:52896485-52954994 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023555
protein coding gene Chr2:47388604-47437473 (+)
CAST/EiJ MGP_CASTEiJ_G0024929
protein coding gene Chr2:50932500-50987270 (+)
CBA/J MGP_CBAJ_G0025444
protein coding gene Chr2:54906627-54959988 (+)
DBA/2J MGP_DBA2J_G0025575
protein coding gene Chr2:49057090-49110671 (+)
FVB/NJ MGP_FVBNJ_G0025537
protein coding gene Chr2:48739811-48793854 (+)
LP/J MGP_LPJ_G0025663
protein coding gene Chr2:51274054-51324324 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025568
protein coding gene Chr2:55954023-56008822 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026207
protein coding gene Chr2:50739022-50795029 (+)
PWK/PhJ MGP_PWKPhJ_G0024670
protein coding gene Chr2:48929571-48985066 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024476
protein coding gene Chr2:50951631-51004864 (+)
WSB/EiJ MGP_WSBEiJ_G0024996
protein coding gene Chr2:51034087-51088828 (+)



Homology
more
  • Human Ortholog
    RIF1, replication timing regulatory factor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RIF1, replication timing regulatory factor 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 55183
    neXtProt AC: NX_Q5UIP0
    UniProt: Q5UIP0

  • Chr Location
    2q23.3; chr2:151409883-151534200 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 6 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality. Mice homozygous for a gene trap allele exhibit embryonic and postnatal lethality, reduced fertility, and decreased cell proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036202 Ensembl Gene Model | MGI Sequence Detail 49552 C57BL/6J ±  kb
    transcript ENSMUST00000112693 Ensembl | MGI Sequence Detail 8509 Not Applicable  
    polypeptide ENSMUSP00000108313 Ensembl | MGI Sequence Detail 2426 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 22
      Primer pair 3

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1922959, MGI:1923494, MGI:2139159, MGI:2139383
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 7
      Gene Ontology 14
      Phenotypes 21
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:265299 Mirman Z, et al., 53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polalpha-dependent fill-in. Nature. 2018 Aug;560(7716):112-116

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory