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Rif1
Gene Detail
Symbol

Name
ID
Rif1
Rap1 interacting factor 1 homolog (yeast)
MGI:1098622
Synonyms
5730435J01Rik, 6530403D07Rik, D2Ertd145e
Feature Type
protein coding gene
Genetic Map
Chromosome 2
29.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:52072842-52122383 bp, + strand
From VEGA annotation of GRCm38

  49542 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41231  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: RIF1
Gene Tree: Rif1

Human
homologs
RIF1, replication timing regulatory factor 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 55183
neXtProt AC: NX_Q5UIP0

Human Chr (Location): 2q23.3; chr2:151409883-151534202 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(76) : Chemically induced (ENU)(1) Gene trapped(70) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit embryonic lethality. Mice homozygous for a gene trap allele exhibit embryonic and postnatal lethality, reduced fertility, and decreased cell proliferation.
 
Interactions
Rif1 interacts with 302 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell cycle, cellular response to DNA damage stimulus, ...
Component chromosome, chromosome, telomeric region, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (151)    Tissues (77)    Images (45)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 52
RNA in situ 33
Northern blot 12
Western blot 10
RT-PCR 44
cDNA source data(21)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase rif1    NEW 
Molecular
reagents
All nucleic(24) cDNA(21) Primer pair(3)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000012437 (Evidence)
Ensembl Gene Model ENSMUSG00000036202 (Evidence)
Entrez Gene 51869 (Evidence)
DFCI TC1606318, TC1621632, TC1620605, TC1574995
DoTS DT.97392446, DT.87053699, DT.532722, DT.40181032, DT.110703956, DT.110703950, DT.101735397, DT.101722111, DT.101362328
NIA Mouse Gene Index U042291, U001752
Consensus CDS Project CCDS50583.1
International Mouse Phenotyping Consortium Status Rif1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012437 VEGA Gene Model | MGI Sequence Detail 49542 C57BL/6J ±  kb
transcript OTTMUST00000029579 VEGA | MGI Sequence Detail 8497 Not Applicable 
polypeptide OTTMUSP00000013312 VEGA | MGI Sequence Detail 2426 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(12) UniProt(3)
Polymorphisms
SNPs within 2kb(282 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR022031 Rap1-interacting factor 1 N-terminal
Protein Ontology PR:000014000 telomere-associated protein RIF1
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:213416 Dan J, et al., Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. Dev Cell. 2014 Apr 14;29(1):7-19
All references(56)
Other
accession IDs
MGI:1922959, MGI:1923494, MGI:2139159, MGI:2139383

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory