Rif1
Gene Detail

Symbol Name ID

Rif1 Rap1 interacting factor 1 homolog (yeast) MGI:1098622

Synonyms

5730435J01Rik, 6530403D07Rik, D2Ertd145e

Feature Type

protein coding gene

Genetic Map

Chromosome 2

29.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr2:52072842-52122383 bp, + strand From VEGA annotation of GRCm38   49542 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:41231  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rif1

Human homologs

Human Homolog		RIF1, RAP1 interacting factor homolog (yeast)
NCBI Gene ID		55183
neXtProt AC		NX_Q5UIP0
Human Chr (Location)		2q23.3; chr2:152266397-152333860 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(75) : Targeted(5) Gene trapped(70)
 

Mice homozygous for a knock-out allele exhibit embryonic lethality. Mice homozygous for a gene trap allele exhibit embryonic and postnatal lethality, reduced fertility, and decreased cell proliferation.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	cell cycle, response to DNA damage stimulus, ...
Component	chromosome, chromosome, telomeric region, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (158)    Tissues (77)    Images (45)
Theiler Stages: 1, 2, 3, 4, 5, 6, 8, 9, 11, 13, 15, 19, 20, 21, 23, 25, 28

Assay Type	Results
Immunohistochemistry	52
RNA in situ	33
Northern blot	12
Western blot	10
RT-PCR	51

cDNA source data(20)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(23) cDNA(20) Primer pair(3)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000012437 (Evidence)
Ensembl Gene Model	ENSMUSG00000036202 (Evidence)
Entrez Gene	51869 (Evidence)
DFCI	TC1574995, TC1620605, TC1621632
DoTS	DT.101722111, DT.101735397, DT.110703950, DT.110703956, DT.40181032, DT.532722, DT.87053699, DT.97392446
NIA Mouse Gene Index	U001752
Consensus CDS Project	CCDS50583.1
International Mouse Knockout Project Status	Rif1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000012437	VEGA Gene Model | MGI Sequence Detail	49542	C57BL/6J
transcript	OTTMUST00000029579	VEGA | MGI Sequence Detail	8497	Not Applicable
polypeptide	OTTMUSP00000013312	VEGA | MGI Sequence Detail	2426	Not Applicable

All sequences(62) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(188 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR022031	Rap1-interacting factor 1 N-terminal
Protein Ontology	PR:000014000	telomere-associated protein RIF1

References

(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:193247 Zimmermann M, et al., 53BP1 regulates DSB repair using Rif1 to control 5' end resection. Science. 2013 Feb 8;339(6120):700-4
All references(53)

Other accession IDs

MGI:1922959, MGI:1923494, MGI:2139159, MGI:2139383