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Psmc3ip
Gene Detail
Symbol

Name
ID
Psmc3ip
proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein
MGI:1098610
Synonyms
HOP2, Tbpip
Feature Type
protein coding gene
Genetic Map
Chromosome 11
64.19 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:101091823-101095436 bp, - strand
From VEGA annotation of GRCm38

  3614 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5940  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PSMC3IP
Gene Tree: Psmc3ip

Human
homologs
PSMC3IP, PSMC3 interacting protein
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 29893
neXtProt AC: NX_Q9P2W1

Human Synonyms: GT198, HOP2, HUMGT198A, ODG3, TBPIP

Human Chr (Location): 17q21.2; chr17:42572310-42577831 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PSMC3IP

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(8) Targeted(4)
Genomic Mutations involving Psmc3ip (1)
 
Homozygotes for targeted null mutations are mice were viable, showed no overt anatomical defects in somatic tissues, but are infertile in both sex due to absence of gametes.
 
Interactions
Psmc3ip interacts with 75 markers (Mir15a, Mir18, Mir18b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process DNA recombination, meiotic cell cycle, ...
Component nucleus
Function androgen receptor binding, DBD domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (107)    Tissues (8)    Images (46)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 107
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase psmc3ip    NEW 
Molecular
reagents
All nucleic(7) cDNA(7)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000002691 (Evidence)
Ensembl Gene Model ENSMUSG00000019303 (Evidence)
Entrez Gene 19183 (Evidence)
NIA Mouse Gene Index U033442
PDB 2MH2
Consensus CDS Project CCDS25448.1
International Mouse Phenotyping Consortium Status Psmc3ip
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002691 VEGA Gene Model | MGI Sequence Detail 3614 C57BL/6J ±  kb
transcript OTTMUST00000005301 VEGA | MGI Sequence Detail 1291 Not Applicable 
polypeptide OTTMUSP00000002517 VEGA | MGI Sequence Detail 217 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(18 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010776 Tat binding protein 1-interacting
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000013381 homologous-pairing protein 2
References
(Earliest) J:43564 Tanaka T, et al., Molecular cloning and characterization of a novel TBP-1 interacting protein (TBPIP):enhancement of TBP-1 action on Tat by TBPIP. Biochem Biophys Res Commun. 1997 Oct 9;239(1):176-81
(Latest) J:211905 Zhao W, et al., Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairing. Nucleic Acids Res. 2014 Jan;42(2):906-17
All references(41)
Other
accession IDs
MGI:2144650

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory