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Tmem222 Gene Detail
Summary
  • Symbol
    Tmem222
  • Name
    transmembrane protein 222
  • Synonyms
    5730406H10Rik, D4Ertd196e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098568
    NCBI Gene: 52174
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:132993356-133005101 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 66.25 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    385 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098568
 protein coding gene Chr4:132993356-133005103 (-)
129S1/SvImJ ENSMUSG00200020884
 protein coding gene Chr4:126438257-126450215 (-)
A/J ENSMUSG00195038515
 protein coding gene Chr4:127766153-127778110 (-)
AKR/J ENSMUSG00220040492
 protein coding gene Chr4:126757932-126769889 (-)
BALB/cJ ENSMUSG00180046919
 protein coding gene Chr4:125400070-125412028 (-)
C3H/HeJ ENSMUSG00175036017
 protein coding gene Chr4:126412207-126424164 (-)
C57BL/6NJ ENSMUSG00215049584
 protein coding gene Chr4:127924108-127935859 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026586
 protein coding gene Chr4:122916062-122927690 (-)
CAST/EiJ ENSTCUG00005044937
 protein coding gene Chr4:127317291-127329275 (-)
CBA/J ENSMUSG00210053030
 protein coding gene Chr4:126041191-126053151 (-)
DBA/2J ENSMUSG00185052518
 protein coding gene Chr4:127573624-127585581 (-)
FVB/NJ ENSMUSG00205030160
 protein coding gene Chr4:125823466-125835399 (-)
JF1/MsJ ENSUMUG00000013967
 protein coding gene Chr4:128244764-128256790 (-)
LP/J ENSMUSG00230032253
 protein coding gene Chr4:131375941-131388830 (-)
NOD/ShiLtJ ENSMUSG00190048207
 protein coding gene Chr4:125805996-125817953 (-)
NZO/HlLtJ ENSMUSG00225024931
 protein coding gene Chr4:137290158-137301907 (-)
PWK/PhJ ENSLUMG00010049129
 protein coding gene Chr4:125257418-125269370 (-)
SPRET/EiJ ENSMSPG00010039685
 protein coding gene Chr4:127334818-127345514 (-)
WSB/EiJ ENSIUOG00005032416
 protein coding gene Chr4:125697639-125709593 (-)



Homology
more
  • Human Ortholog
    TMEM222, transmembrane protein 222
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM222, transmembrane protein 222
  • Synonyms
    C1orf160, NEDMOSBA
  • Links
    NCBI Gene ID: 84065
    UniProt: Q9H0R3

  • Chr Location
    1p36.11; chr1:27322139-27336401 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    662
  • Tissues
    53
  • cDNA Data
    69
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 52174 NCBI Gene Model | MGI Sequence Detail 11746 C57BL/6J ±  kb
transcript NM_025667 RefSeq | MGI Sequence Detail 1497 ZRU/MplStud  
polypeptide Q8BVA2 UniProt | EBI | MGI Sequence Detail 208 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 72
    cDNA 71
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:1913873, MGI:2140146
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 13
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory