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Astn1
Gene Detail
Symbol

Name
ID
Astn1
astrotactin 1
MGI:1098567
Synonyms
mKIAA0289
Feature Type
protein coding gene
Genetic Map
Chromosome 1
68.35 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:158362273-158691781 bp, + strand
From VEGA annotation of GRCm38

  329509 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7233  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ASTN1
Gene Tree: Astn1

Human
homologs
ASTN1, astrotactin 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 460
neXtProt AC: NX_O14525

Human Synonyms: ASTN

Human Chr (Location): 1q25.2; chr1:176857305-177164904 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in reduced cerebellum size, abnormal Purkinje cell morphology, and reduced coordination performance on the Rotarod test.
 
Interactions
Astn1 interacts with 387 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cell adhesion, cell migration, ...
Component endosome, external side of plasma membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (60)    Tissues (37)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 49
Western blot 11
cDNA source data(96)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase astn1    NEW 
Molecular
reagents
All nucleic(96) cDNA(96)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000050031 (Evidence)
Ensembl Gene Model ENSMUSG00000026587 (Evidence)
Entrez Gene 11899 (Evidence)
UniGene 329586
DFCI TC1597169, TC1601141, TC1608084, TC1630366
DoTS DT.101398650, DT.101398655, DT.110911497, DT.55160010, DT.91315785
NIA Mouse Gene Index U000967
Consensus CDS Project CCDS56648.1, CCDS78721.1
International Mouse Phenotyping Consortium Status Astn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050031 VEGA Gene Model | MGI Sequence Detail 329509 C57BL/6J ±  kb
transcript OTTMUST00000127283 VEGA | MGI Sequence Detail 7248 Not Applicable 
polypeptide OTTMUSP00000068709 VEGA | MGI Sequence Detail 1302 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(10) UniProt(8)
Polymorphisms
SNPs within 2kb(3569 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026995 Astrotactin
InterPro IPR000742 EGF-like domain
InterPro IPR003961 Fibronectin type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR020864 Membrane attack complex component/perforin (MACPF) domain
Protein Ontology PR:000004389 astrotactin-1
References
(Earliest) J:192652 Fishell G, et al., Astrotactin provides a receptor system for CNS neuronal migration. Development. 1991 Nov;113(3):755-65
(Latest) J:187345 Piper M, et al., Nuclear factor one X regulates the development of multiple cellular populations in the postnatal cerebellum. J Comp Neurol. 2011 Dec 1;519(17):3532-48
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory