About   Help   FAQ
Astn1
Gene Detail
Symbol

Name
ID
Astn1
astrotactin 1
MGI:1098567
Synonyms
mKIAA0289
Feature Type
protein coding gene
Genetic Map
Chromosome 1
68.35 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:158362304-158691786 bp, + strand
From NCBI annotation of GRCm38

  329483 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7233  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Astn1

Human
homologs
Human Homolog ASTN1, astrotactin 1
NCBI Gene ID 460
neXtProt AC  NX_O14525
Human Synonyms  ASTN
Human Chr (Location)  1q25.2; chr1:176857305-177164904 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in reduced cerebellum size, abnormal Purkinje cell morphology, and reduced coordination performance on the Rotarod test.
 
Interactions
Astn1 interacts with 388 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cell adhesion, cell migration, ...
Component endosome, external side of plasma membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (60)    Tissues (37)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 49
Western blot 11
cDNA source data(96)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(96) cDNA(96)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000026587 (Evidence)
Entrez Gene11899 (Evidence)
UniGene329586
DFCITC1630366, TC1608084, TC1597169, TC1601141
DoTSDT.91315785, DT.110911497, DT.101398655, DT.101398650, DT.55160010
NIA Mouse Gene IndexU000967
Consensus CDS ProjectCCDS56648.1
International Mouse Knockout Project StatusAstn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11899 NCBI Gene Model | MGI Sequence Detail 329483 C57BL/6J ±  kb
transcript NM_001205204 RefSeq | MGI Sequence Detail 7241 C57BL/6 
polypeptide Q61137 UniProt | EBI | MGI Sequence Detail 1302 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(3569 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026995 Astrotactin
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR020864 Membrane attack complex component/perforin (MACPF) domain
Protein Ontology PR:000004389 astrotactin-1
Graphical View of Protein Domain Structure
References
(Earliest) J:192652 Fishell G, et al., Astrotactin provides a receptor system for CNS neuronal migration. Development. 1991 Nov;113(3):755-65
(Latest) J:187345 Piper M, et al., Nuclear factor one X regulates the development of multiple cellular populations in the postnatal cerebellum. J Comp Neurol. 2011 Dec 1;519(17):3532-48
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory