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Nhp2
Gene Detail
Symbol

Name
ID
Nhp2
NHP2 ribonucleoprotein
MGI:1098547
Synonyms
2410130M07Rik, D11Ertd175e, H/ACA small nucleolar RNPs, NHP2, Nola2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
31.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:51619735-51623714 bp, + strand
From VEGA annotation of GRCm38

  3980 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5524  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ribosomal protein, L7Ab/L7Aa/L7Ae/L8e types/H/ACA ribonucleoprotein complex, NHP2 subunit
Gene Tree: Nhp2

Human
homologs
Human Homolog NHP2, NHP2 ribonucleoprotein
NCBI Gene ID 55651
neXtProt AC  NX_Q9NX24
Human Synonyms  DKCB2, NHP2P, NOLA2
Human Chr (Location)  5q35.3; chr5:178149463-178153960 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NHP2
Mutations,
alleles, and
phenotypes
All mutations/alleles(36) : Gene trapped(34) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Nhp2 interacts with 59 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process ribosome biogenesis, rRNA processing
Component cytoplasm, nucleolus, ...
Function poly(A) RNA binding, RNA binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (10)    Tissues (3)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 10
cDNA source data(93)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(95) cDNA(94) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000005610 (Evidence)
Ensembl Gene ModelENSMUSG00000001056 (Evidence)
Entrez Gene52530 (Evidence)
UniGene28203
DFCITC1573084
DoTSDT.495313
NIA Mouse Gene IndexU012572
Consensus CDS ProjectCCDS24655.1
International Mouse Knockout Project StatusNhp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005610 VEGA Gene Model | MGI Sequence Detail 3980 C57BL/6J ±  kb
transcript OTTMUST00000012482 VEGA | MGI Sequence Detail 1042 Not Applicable 
polypeptide OTTMUSP00000005780 VEGA | MGI Sequence Detail 153 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(46 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002415 H/ACA ribonucleoprotein complex, subunit Nhp2, eukaryote
InterPro IPR004038 Ribosomal protein L7Ae/L30e/S12e/Gadd45
InterPro IPR018492 Ribosomal protein L7Ae/L8/Nhp2 family
Protein Ontology PR:000011202 H/ACA ribonucleoprotein complex subunit 2
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(38)
Other
accession IDs
MGI:1915487

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory