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Rgs5
Gene Detail
Symbol

Name
ID
Rgs5
regulator of G-protein signaling 5
MGI:1098434
Synonyms
1110070A02Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 1
76.84 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr1:169655501-169695813 bp, + strand
From VEGA annotation of GRCm38

  40313 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2682  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RGS5
Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs5

Human
homologs
RGS5, regulator of G-protein signaling 5
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8490
neXtProt AC: NX_O15539

Human Synonyms: MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129

Human Chr (Location): 1q23.1; chr1:163142299-163321791 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human RGS5

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation appear normal.
 
Interactions
Rgs5 interacts with 315 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (16 records)
Data Summary: Results (440)    Tissues (245)    Images (71)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 321
In situ reporter (knock in) 76
RT-PCR 43
cDNA source data(125)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase rgs5 ; ZFIN rgs5a, rgs5b    NEW 
Molecular
reagents
All nucleic(129) cDNA(125) Primer pair(3) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000020901 (Evidence)
Ensembl Gene Model ENSMUSG00000026678 (Evidence)
Entrez Gene 19737 (Evidence)
UniGene 20954
DFCI TC1580116, TC1580888, TC1580996, TC1597457, TC1640010
DoTS DT.533805, DT.91343316
NIA Mouse Gene Index U001065
Consensus CDS Project CCDS15464.1
International Mouse Phenotyping Consortium Status Rgs5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020901 VEGA Gene Model | MGI Sequence Detail 40313 C57BL/6J ±  kb
transcript OTTMUST00000049406 VEGA | MGI Sequence Detail 4096 Not Applicable 
polypeptide OTTMUSP00000022882 VEGA | MGI Sequence Detail 181 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(614 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016137 RGS domain
InterPro IPR024066 RGS, subdomain 1
Protein Ontology PR:000013960 regulator of G-protein signaling 5
References
(Earliest) J:39294 Chen C, et al., Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast. J Biol Chem. 1997 Mar 28;272(13):8679-85
(Latest) J:223464 Bahrami AJ, et al., Regulator of G-protein signaling-5 is a marker of hepatic stellate cells and expression mediates response to liver injury. PLoS One. 2014;9(10):e108505
All references(65)
Other
accession IDs
MGI:1919050

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory