Rgs5
Gene Detail

Symbol Name ID

Rgs5 regulator of G-protein signaling 5 MGI:1098434

Synonyms

1110070A02Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 1

76.84 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr1:169655501-169695813 bp, + strand From VEGA annotation of GRCm38   40313 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Rgs5 ± 2 cM)

Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs5

Human ortholog

RGS5 regulator of G-protein signaling 5 NCBI Gene ID 8490
Human Synonyms: MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129
Human Chr1:163112089-163172963 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human RGS5 (1)

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Mice homozygous for a targeted mutation appear normal.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	G-protein coupled receptor signaling pathway, negative regulation of G-protein coupled receptor protein signaling pathway, ...
Component	cytoplasm, membrane, ...
Function	GTPase activator activity

External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (355)    Tissues (162)    Images (69)
Theiler Stages: 17, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	236
In situ reporter (knock in)	76
RT-PCR	43

cDNA source data(142)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(146) cDNA(142) Primer pair(3) Other(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000020901 (Evidence)
Ensembl Gene Model	ENSMUSG00000026678 (Evidence)
Entrez Gene	19737 (Evidence)
UniGene	20954
DFCI	TC1580116, TC1580888, TC1580996, TC1597457, TC1640010
DoTS	DT.533805, DT.91343316
NIA Mouse Gene Index	U001065
Consensus CDS Project	CCDS15464.1
International Mouse Knockout Project Status	Rgs5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020901	VEGA Gene Model | MGI Sequence Detail	40313	C57BL/6J
transcript	OTTMUST00000049406	VEGA | MGI Sequence Detail	4096	Not Applicable
polypeptide	OTTMUSP00000022882	VEGA | MGI Sequence Detail	181	Not Applicable

All sequences(32) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(413 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024066	Regulator of G-protein signaling, domain 1
InterPro	IPR000342	Regulator of G protein signalling
InterPro	IPR016137	Regulator of G protein signalling superfamily
Protein Ontology	PR:000013960	regulator of G-protein signaling 5

References

(Earliest) J:39294 Chen C, et al., Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast. J Biol Chem. 1997 Mar 28;272(13):8679-85
(Latest) J:192855 Qin M, et al., Absence of Rgs5 prolongs cardiac repolarization and predisposes to ventricular tachyarrhythmia in mice. J Mol Cell Cardiol. 2012 Dec;53(6):880-90
All references(59)

Other accession IDs

MGI:1919050