Rgs5 MGI Mouse Gene Detail - MGI:1098434 - regulator of G-protein signaling 5

Symbol

Rgs5
Name

regulator of G-protein signaling 5
Synonyms

1110070A02Rik

Feature Type

protein coding gene
IDs

MGI:1098434
NCBI Gene: 19737
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:169483070-169523367 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 76.84 cM, cytoband H2
Mapping Data

6 experiments

SNPs within 2kb

1314 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098434	protein coding gene	Chr1:169483070-169523382 (+)
129S1/SvImJ	ENSMUSG00200043798	protein coding gene	Chr1:166931413-166978981 (+)
A/J	ENSMUSG00195045124	protein coding gene	Chr1:166256657-166296931 (+)
AKR/J	ENSMUSG00220027277	protein coding gene	Chr1:165974658-166014958 (+)
BALB/cJ	ENSMUSG00180039089	protein coding gene	Chr1:166541759-166582064 (+)
C3H/HeJ	ENSMUSG00175043034	protein coding gene	Chr1:166587822-166635375 (+)
C57BL/6NJ	ENSMUSG00215041650	protein coding gene	Chr1:166423731-166464037 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014831	protein coding gene	Chr1:159927476-159967461 (+)
CAST/EiJ	ENSTCUG00005042959	protein coding gene	Chr1:164934148-164974562 (+)
CBA/J	ENSMUSG00210034912	protein coding gene	Chr1:166507645-166547949 (+)
DBA/2J	ENSMUSG00185011481	protein coding gene	Chr1:170724373-170764691 (+)
FVB/NJ	ENSMUSG00205020079	protein coding gene	Chr1:165449093-165498095 (+)
JF1/MsJ	ENSUMUG00000008463	protein coding gene	Chr1:169867400-169907720 (+)
LP/J	ENSMUSG00230025990	protein coding gene	Chr1:170319093-170368134 (+)
NOD/ShiLtJ	ENSMUSG00190024754	protein coding gene	Chr1:166256608-166296870 (+)
NZO/HlLtJ	ENSMUSG00225004362	protein coding gene	Chr1:173938513-173980220 (+)
PWK/PhJ	ENSLUMG00010031995	protein coding gene	Chr1:165235418-165275672 (+)
SPRET/EiJ	ENSMSPG00010044555	protein coding gene	Chr1:168803923-168841017 (+)
WSB/EiJ	ENSIUOG00005034165	protein coding gene	Chr1:165680172-165720430 (+)

Human Ortholog

RGS5, regulator of G protein signaling 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RGS5, regulator of G protein signaling 5
Synonyms

MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129
Links

HGNC:10001

NCBI Gene ID: 8490

UniProt: O15539
Chr Location

1q23.3; chr1:163111121-163321791 (-) GRCh38

MGI Vertebrate Homology

Rgs5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RGS5
Gene Tree

Rgs5

Diseases

2 with human RGS5 associations

				Human Disease	Mouse Models
				colorectal adenocarcinoma IDs colorectal adenocarcinoma DOID:0050861 NCI:C5105 UMLS_CUI:C1319315
				essential hypertension IDs essential hypertension DOID:10825 ICD10CM:I10 ICD9CM:401 ICD9CM:401.9 MESH:D000075222 NCI:C3478 OMIM:145500 OMIM:603918 OMIM:604329 OMIM:607329 OMIM:608742 OMIM:610261 OMIM:610262 OMIM:610948 OMIM:611014 ORDO:243761 UMLS_CUI:C0085580

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 4 alleles in 3 genetic backgrounds
8 phenotypes from multigenic genotypes
38 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

2
Endonuclease-mediated

4
Targeted

8
Genomic Mutations

2 involving Rgs5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted mutation appear normal.

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All GO Annotations

16
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1159
Tissues

270
cDNA Data

129
Literature Summary

33

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rgs5

ZFIN rgs5a, rgs5b

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All Sequences

43
RefSeq

4
UniProt

2
CCDS

CCDS15464.1, CCDS83629.1

Ensembl

ENSMUSG00000026678 (Evidence)
NCBI Gene

19737

			Length	Strain/Species	Flank
genomic	19737	NCBI Gene Model \| MGI Sequence Detail	40298	C57BL/6J	± kb
transcript	NM_009063	RefSeq \| MGI Sequence Detail	4081	C57BL/6
polypeptide	O08850	UniProt \| EBI \| MGI Sequence Detail	181	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013960 regulator of G-protein signaling 5

(term hierarchy)
InterPro Domains

IPR034956 Regulator of G-protein signalling 5, RGS domain

IPR016137 RGS domain

IPR036305 RGS domain superfamily

IPR024066 RGS, subdomain 1/3

IPR044926 RGS, subdomain 2

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All nucleic 138

cDNA 129

Primer pair 6

Other 3

Microarray probesets 8

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MGI:1919050

Summaries

All 117

Developmental Gene Expression 33

Gene Ontology 8

Phenotypes 38
Earliest

J:39294 Chen C, et al., Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast. J Biol Chem. 1997 Mar 28;272(13):8679-85
Latest

J:387141 Buizza C, et al., Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation. Mol Oncol. 2025 Sep;19(9):2491-2514

TSS for Rgs5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9914	Chr1:169483062-169483077 (+)	0 bp
Tssr9915	Chr1:169520142-169520147 (+)	37,075 bp
Tssr9916	Chr1:169521235-169521264 (+)	38,180 bp
Tssr9917	Chr1:169521396-169521416 (+)	38,336 bp
Tssr276	Chr1:169521599-169521624 (+)	38,542 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24