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Rgs5
Gene Detail
 Symbol
Name
ID
Rgs5
regulator of G-protein signaling 5
MGI:1098434
Synonyms 1110070A02Rik
Feature Type protein coding gene
Genetic Map
Chromosome 1
76.84 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr1:169655501-169695813 bp, + strand
From VEGA annotation of GRCm38

  40313 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2682  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs5

Human
homologs
Human Homolog RGS5, regulator of G-protein signaling 5
NCBI Gene ID 8490
neXtProt AC  NX_O15539
Human Synonyms  MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129
Human Chr (Location)  1q23.1; chr1:163142299-163321791 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human RGS5
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation appear normal.
 
Interactions
Rgs5 interacts with 315 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process G-protein coupled receptor signaling pathway, negative regulation of G-protein coupled receptor protein signaling pathway, ...
Component cytoplasm, membrane, ...
Function GTPase activator activity
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (441)    Tissues (246)    Images (71)
Theiler Stages: 17, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 322
In situ reporter (knock in) 76
RT-PCR 43
cDNA source data(125)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(129) cDNA(125) Primer pair(3) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000020901 (Evidence)
Ensembl Gene ModelENSMUSG00000026678 (Evidence)
Entrez Gene19737 (Evidence)
UniGene20954
DFCITC1580116, TC1580888, TC1580996, TC1597457, TC1640010
DoTSDT.533805, DT.91343316
NIA Mouse Gene IndexU001065
Consensus CDS ProjectCCDS15464.1
International Mouse Knockout Project StatusRgs5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020901 VEGA Gene Model | MGI Sequence Detail 40313 C57BL/6J ±  kb
transcript OTTMUST00000049406 VEGA | MGI Sequence Detail 4096 Not Applicable 
polypeptide OTTMUSP00000022882 VEGA | MGI Sequence Detail 181 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(614 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024066 Regulator of G-protein signaling, domain 1
InterPro IPR000342 Regulator of G protein signalling
InterPro IPR016137 Regulator of G protein signalling superfamily
Protein Ontology PR:000013960 regulator of G-protein signaling 5
References (Earliest) J:39294 Chen C, et al., Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast. J Biol Chem. 1997 Mar 28;272(13):8679-85
(Latest) J:196361 Cappellari O, et al., Dll4 and PDGF-BB convert committed skeletal myoblasts to pericytes without erasing their myogenic memory. Dev Cell. 2013 Mar 25;24(6):586-99
All references(64)
Other
accession IDs
MGI:1919050

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory