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Rgs5 Gene Detail
Summary
  • Symbol
    Rgs5
  • Name
    regulator of G-protein signaling 5
  • Synonyms
    1110070A02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098434
    NCBI Gene: 19737
Location & Maps
more
  • Sequence Map
    Chr1:169655501-169695813 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40313 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RGS5, regulator of G-protein signaling 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RGS5, regulator of G-protein signaling 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129
  • Links
    NCBI Gene ID: 8490
    neXtProt AC: NX_O15539

  • Chr Location
    1q23.1; chr1:163142299-163321791 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human RGS5 associations

Human Disease Mouse Models
       Hypertension, Essential   OMIM: 145500
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 4 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    2
  • Targeted
    8
  • Genomic Mutations
    2 involving Rgs5
  • Incidental Mutations
Mice homozygous for a targeted mutation appear normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020901 VEGA Gene Model | MGI Sequence Detail 40313 C57BL/6J ±  kb
transcript OTTMUST00000049406 VEGA | MGI Sequence Detail 4096 Not Applicable  
polypeptide OTTMUSP00000022882 VEGA | MGI Sequence Detail 181 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    614 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 129
    cDNA 125
    Primer pair 3
    Other 1

    Microarray probesets 8
Other
Accession IDs
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MGI:1919050
References
more
  • Summaries
    All 62
    Developmental Gene Expression 16
    Gene Ontology 5
    Phenotypes 17
  • Earliest
    J:39294 Chen C, et al., Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast. J Biol Chem. 1997 Mar 28;272(13):8679-85
  • Latest
    J:223464 Bahrami AJ, et al., Regulator of G-protein signaling-5 is a marker of hepatic stellate cells and expression mediates response to liver injury. PLoS One. 2014;9(10):e108505

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory