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Cpt1b
Gene Detail
Symbol

Name
ID
Cpt1b
carnitine palmitoyltransferase 1b, muscle
MGI:1098297
Synonyms
Cpt1, M-CPTI, M-CPT I
Feature Type
protein coding gene
Genetic Map
Chromosome 15
44.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:89416405-89425863 bp, - strand
From VEGA annotation of GRCm38

  9459 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22548  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Cpt1b

Human
homologs
Human Homolog CPT1B, carnitine palmitoyltransferase 1B (muscle)
NCBI Gene ID 1375
neXtProt AC  NX_Q92523
Human Synonyms  CPT1M, CPT1-M, CPTI, CPTI-M, MCCPT1, MCPT1, M-CPT1
Human Chr (Location)  22q13.33; chr22:50568861-50578667 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Radiation induced(1) Targeted(2)
Genomic Mutations involving Cpt1b (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice die in utero prior to E9.5. Heterozygous mutant mice exhibit susceptibility to fatal hypothermia following cold exposure, with females more severely affected.
 
Interactions
Cpt1b interacts with 73 markers (Mir7-1, Mir92-2, Mir105, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (110)    Tissues (105)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 9
RT-PCR 7
cDNA source data(31)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) Genomic(3) cDNA(32) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000035434 (Evidence)
Ensembl Gene ModelENSMUSG00000078937 (Evidence)
Entrez Gene12895 (Evidence)
UniGene227738
DFCITC1581482
EC2.3.1.21
Consensus CDS ProjectCCDS27749.1
International Mouse Knockout Project StatusCpt1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035434 VEGA Gene Model | MGI Sequence Detail 9459 C57BL/6J ±  kb
transcript OTTMUST00000090606 VEGA | MGI Sequence Detail 2895 Not Applicable 
polypeptide OTTMUSP00000049742 VEGA | MGI Sequence Detail 772 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(15 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000542 Acyltransferase ChoActase/COT/CPT
Protein Ontology PR:000005836 carnitine O-palmitoyltransferase 1, muscle isoform
References
(Earliest) J:16140 Gelb BD, Genomic structure of and a cardiac promoter for the mouse carnitine palmitoyltransferase II gene. Genomics. 1993 Dec;18(3):651-5
(Latest) J:202192 He L, et al., Carnitine palmitoyltransferase-1b deficiency aggravates pressure overload-induced cardiac hypertrophy caused by lipotoxicity. Circulation. 2012 Oct 2;126(14):1705-16
All references(47)
Other
accession IDs
MGD-MRK-2118

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory