Cpt1b
Gene Detail

Symbol Name ID

Cpt1b carnitine palmitoyltransferase 1b, muscle MGI:1098297

Synonyms

Cpt1, M-CPTI, M-CPT I

Feature Type

protein coding gene

Genetic Map

Chromosome 15

44.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr15:89416405-89425863 bp, - strand From VEGA annotation of GRCm38   9459 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22548  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Cpt1b

Human homologs

Human Homolog		CPT1B, carnitine palmitoyltransferase 1B (muscle)
NCBI Gene ID		1375
neXtProt AC		NX_Q92523
Human Synonyms		CPT1M, CPT1-M, CPTI, CPTI-M, MCCPT1, MCPT1, M-CPT1
Human Chr (Location)		22q13.33; chr22:51007290-51017096 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Homozygous null mice die in utero prior to E9.5. Heterozygous mutant mice exhibit susceptibility to fatal hypothermia following cold exposure, with females more severely affected.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	fatty acid metabolic process, lipid metabolic process, ...
Component	integral to membrane, intracellular membrane-bounded organelle, ...
Function	carnitine O-palmitoyltransferase activity, transferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (116)    Tissues (108)    Images (3)
Theiler Stages: 1, 2, 3, 4, 5, 22, 24, 26, 28

Assay Type	Results
RNA in situ	94
Northern blot	9
RT-PCR	13

cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(37) Genomic(3) cDNA(32) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000035434 (Evidence)
Ensembl Gene Model	ENSMUSG00000078937 (Evidence)
Entrez Gene	12895 (Evidence)
UniGene	227738
DFCI	TC1581482
EC	2.3.1.21
Consensus CDS Project	CCDS27749.1
International Mouse Knockout Project Status	Cpt1b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035434	VEGA Gene Model | MGI Sequence Detail	9459	C57BL/6J
transcript	OTTMUST00000090606	VEGA | MGI Sequence Detail	2895	Not Applicable
polypeptide	OTTMUSP00000049742	VEGA | MGI Sequence Detail	772	Not Applicable

All sequences(34) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(11 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000542	Acyltransferase ChoActase/COT/CPT
Protein Ontology	PR:000005836	carnitine O-palmitoyltransferase 1, muscle isoform

References

(Earliest) J:16140 Gelb BD, Genomic structure of and a cardiac promoter for the mouse carnitine palmitoyltransferase II gene. Genomics. 1993 Dec;18(3):651-5
(Latest) J:186530 Abbott BD, et al., Effects of perfluorooctanoic acid (PFOA) on expression of peroxisome proliferator-activated receptors (PPAR) and nuclear receptor-regulated genes in fetal and postnatal CD-1 mouse tissues. Reprod Toxicol. 2012 Jul;33(4):491-505
All references(44)

Other accession IDs

MGD-MRK-2118