Cpt1a
Gene Detail

Symbol Name ID

Cpt1a carnitine palmitoyltransferase 1a, liver MGI:1098296

Synonyms

Cpt1, CPTI, L-CPT I

Feature Type

protein coding gene

Genetic Map

Chromosome 19

3.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr19:3323301-3385732 bp, + strand From Ensembl annotation of GRCm38   62432 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1413  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Cpt1a

Human homologs

Human Homolog		CPT1A, carnitine palmitoyltransferase 1A (liver)
NCBI Gene ID		1374
neXtProt AC		NX_P50416
Human Synonyms		CPT1, CPT1-L, L-CPT1
Human Chr (Location)		11q13.2; chr11:68522088-68609399 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CPT1A

Alleles and phenotypes

All alleles(38) : Targeted(3) Gene trapped(35)
 

Homozygous null mice display embryonic lethality. Heterozygous null mice display decreased serum glucose and increased serum free fatty acid levels after fasting.

 
Human Diseases Modeled Using Mouse Cpt1a (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (29 annotations)

Process	carnitine metabolic process, eating behavior, ...
Component	integral to membrane, integral to mitochondrial outer membrane, ...
Function	carnitine O-palmitoyltransferase activity, identical protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (352)    Tissues (126)    Images (46)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	352

cDNA source data(139)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(144) Genomic(3) cDNA(140) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000024900 (Evidence)
Entrez Gene	12894 (Evidence)
UniGene	18522
NIA Mouse Gene Index	U038771
EC	2.3.1.21
Consensus CDS Project	CCDS29395.1
International Mouse Knockout Project Status	Cpt1a

Sequences

Length	Strain/Species
genomic	ENSMUSG00000024900	Ensembl Gene Model | MGI Sequence Detail	62432	C57BL/6J
transcript	ENSMUST00000025835	Ensembl | MGI Sequence Detail	4300	Not Applicable
polypeptide	ENSMUSP00000025835	Ensembl | MGI Sequence Detail	773	Not Applicable

All sequences(31) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(171 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000542	Acyltransferase ChoActase/COT/CPT
Protein Ontology	PR:000005835	carnitine O-palmitoyltransferase 1, liver isoform

References

(Earliest) J:16140 Gelb BD, Genomic structure of and a cardiac promoter for the mouse carnitine palmitoyltransferase II gene. Genomics. 1993 Dec;18(3):651-5
(Latest) J:179687 Banks AS, et al., Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice. Cell Metab. 2011 Nov 2;14(5):587-97
All references(47)

Other accession IDs

MGD-MRK-2118, MGI:2147452, MGI:2147463