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Cpt1a
Gene Detail
 Symbol
Name
ID
Cpt1a
carnitine palmitoyltransferase 1a, liver
MGI:1098296
Synonyms Cpt1, CPTI, L-CPT I
Feature Type protein coding gene
Genetic Map
Chromosome 19
3.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:3323301-3385732 bp, + strand
From Ensembl annotation of GRCm38

  62432 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1413  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Cpt1a

Human
homologs
Human Homolog CPT1A, carnitine palmitoyltransferase 1A (liver)
NCBI Gene ID 1374
neXtProt AC  NX_P50416
Human Synonyms  CPT1, CPT1-L, L-CPT1
Human Chr (Location)  11q13.2; chr11:68754620-68841931 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CPT1A
Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(35) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality. Heterozygous null mice display decreased serum glucose and increased serum free fatty acid levels after fasting.
 
Human Diseases Modeled Using Mouse Cpt1a (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Cpt1a interacts with 257 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process carnitine metabolic process, eating behavior, ...
Component integral component of membrane, integral component of mitochondrial outer membrane, ...
Function carnitine O-palmitoyltransferase activity, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (384)    Tissues (159)    Images (47)
Theiler Stages: 22, 23, 26, 27, 28
Assay TypeResults
RNA in situ 384
cDNA source data(155)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(160) Genomic(3) cDNA(156) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000024900 (Evidence)
Entrez Gene12894 (Evidence)
UniGene18522
NIA Mouse Gene IndexU038771
EC2.3.1.21
Consensus CDS ProjectCCDS29395.1
International Mouse Knockout Project StatusCpt1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024900 Ensembl Gene Model | MGI Sequence Detail 62432 C57BL/6J ±  kb
transcript ENSMUST00000025835 Ensembl | MGI Sequence Detail 4300 Not Applicable 
polypeptide ENSMUSP00000025835 Ensembl | MGI Sequence Detail 773 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(14) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(208 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000542 Acyltransferase ChoActase/COT/CPT
Protein Ontology PR:000005835 carnitine O-palmitoyltransferase 1, liver isoform
References (Earliest) J:16140 Gelb BD, Genomic structure of and a cardiac promoter for the mouse carnitine palmitoyltransferase II gene. Genomics. 1993 Dec;18(3):651-5
(Latest) J:197008 Tyra HM, et al., Inhibition of fatty acid oxidation enhances oxidative protein folding and protects hepatocytes from endoplasmic reticulum stress. Mol Biol Cell. 2012 Mar;23(5):811-9
All references(49)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-2118, MGI:2147452, MGI:2147463

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory