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Cpt1a Gene Detail
Summary
  • Symbol
    Cpt1a
  • Name
    carnitine palmitoyltransferase 1a, liver
  • Synonyms
    Cpt1, CPTI, L-CPT I
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098296
    NCBI Gene: 12894
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:3372334-3435733 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 3.08 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1296 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098296
 protein coding gene Chr19:3372328-3435735 (+)
129S1/SvImJ ENSMUSG00200050382
 protein coding gene Chr19:131974-195371 (+)
A/J ENSMUSG00195050910
 protein coding gene Chr19:522822-586242 (+)
AKR/J ENSMUSG00220043001
 protein coding gene Chr19:295851-359258 (+)
BALB/cJ ENSMUSG00180037236
 protein coding gene Chr19:897493-960725 (+)
C3H/HeJ ENSMUSG00175008656
 protein coding gene Chr19:142408-205806 (+)
C57BL/6NJ ENSMUSG00215040232
 protein coding gene Chr19:370213-433621 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022465
 protein coding gene Chr19:72429-132198 (+)
CAST/EiJ ENSTCUG00005039186
 protein coding gene Chr19:280220-343330 (+)
CBA/J ENSMUSG00210042330
 protein coding gene Chr19:142296-206180 (+)
DBA/2J ENSMUSG00185045024
 protein coding gene Chr19:518616-582498 (+)
FVB/NJ ENSMUSG00205035258
 protein coding gene Chr19:512600-576343 (+)
JF1/MsJ ENSUMUG00000039502
 protein coding gene Chr19:504770-570158 (+)
LP/J ENSMUSG00230053535
 protein coding gene Chr19:1438201-1501598 (+)
NOD/ShiLtJ ENSMUSG00190026999
 protein coding gene Chr19:63996-127402 (+)
NZO/HlLtJ ENSMUSG00225025171
 protein coding gene Chr19:5147062-5210461 (+)
PWK/PhJ ENSLUMG00010003864
 protein coding gene Chr19:271693-337108 (+)
SPRET/EiJ ENSMSPG00010032602
 protein coding gene Chr19:262890-323981 (+)
WSB/EiJ ENSIUOG00005046389
 protein coding gene Chr19:138344-201846 (+)



Homology
more
  • Human Ortholog
    CPT1A, carnitine palmitoyltransferase 1A
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPT1A, carnitine palmitoyltransferase 1A
  • Synonyms
    CPT1, CPT1-L, CPT I, CPTI-L, L-CPT1
  • Links
    NCBI Gene ID: 1374
    UniProt: P50416

  • Chr Location
    11q13.3; chr11:68754620-68844410 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cpt1a mouse models; 2 with human CPT1A associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 4 genetic backgrounds
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality. Heterozygous null mice display decreased serum glucose and increased serum free fatty acid levels after fasting.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    71
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1024
  • Tissues
    180
  • cDNA Data
    157
  • Literature Summary
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024900 Ensembl Gene Model | MGI Sequence Detail 63400 C57BL/6J ±  kb
    transcript ENSMUST00000025835 Ensembl | MGI Sequence Detail 4317 Not Applicable  
    polypeptide ENSMUSP00000025835 Ensembl | MGI Sequence Detail 773 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000005835 carnitine O-palmitoyltransferase 1, liver isoform
      (term hierarchy)
    • EC
      2.3.1.-, 2.3.1.21
    • InterPro Domains
      IPR000542 Acyltransferase ChoActase/COT/CPT
      IPR042572 Carnitine o-acyltransferase, N-terminal
      IPR032476 Carnitine O-palmitoyltransferase, N-terminal
      IPR023213 Chloramphenicol acetyltransferase-like domain superfamily
      IPR039551 Choline/Carnitine o-acyltransferase, domain 1 and 2
      IPR042231 Choline/Carnitine o-acyltransferase, domain 2
    • GlyGen
      P97742 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 169
      Genomic 3
      cDNA 158
      Primer pair 7
      Other 1
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-2118, MGI:2147452, MGI:2147463, MGI:88485
    References
    more
    • Summaries
      All 154
      Developmental Gene Expression 31
      Diseases 1
      Gene Ontology 18
      Phenotypes 58
    • Earliest
      J:16140 Gelb BD, Genomic structure of and a cardiac promoter for the mouse carnitine palmitoyltransferase II gene. Genomics. 1993 Dec;18(3):651-5
    • Latest
      J:391504 Shay JES, et al., Ketogenic diet mediates intestinal tumorigenesis through lipids not ketones. Nature. 2026 Aug;656(8127):474-483
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory