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Per1
Gene Detail
Symbol

Name
ID
Per1
period circadian clock 1
MGI:1098283
Synonyms
mPer1, m-rigui
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.37 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:69095217-69109960 bp, + strand
From VEGA annotation of GRCm38

  14744 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1966  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: PER1
Gene Tree: Per1

Human
homologs
PER1, period circadian clock 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5187
neXtProt AC: NX_O15534

Human Synonyms: hPER, PER, RIGUI

Human Chr (Location): 17p13.1; chr17:8140470-8156405 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(12) Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display a persistent circadian rhythm, but they have a shorter period and their ability to maintain the precision and the stability of the period is impaired.
 
Human Diseases Modeled in Mice Using Per1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Per1 interacts with 203 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process circadian regulation of gene expression, circadian regulation of translation, ...
Component cytoplasm, nucleus
Function chromatin DNA binding, E-box binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (121)    Tissues (118)    Images (26)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 112
RT-PCR 5
cDNA source data(62)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase per1 ; ZFIN per1a, per1b    NEW 
Molecular
reagents
All nucleic(69) Genomic(1) cDNA(65) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005970 (Evidence)
Ensembl Gene Model ENSMUSG00000020893 (Evidence)
Entrez Gene 18626 (Evidence)
UniGene 7373
DFCI TC1588671, TC1578230
DoTS DT.529588, DT.94297792, DT.94198914, DT.110529609, DT.101409795
NIA Mouse Gene Index U012810
PDB 4DJ2
Consensus CDS Project CCDS24882.1
International Mouse Phenotyping Consortium Status Per1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005970 VEGA Gene Model | MGI Sequence Detail 14744 C57BL/6J ±  kb
transcript OTTMUST00000013334 VEGA | MGI Sequence Detail 4671 Not Applicable 
polypeptide OTTMUSP00000006173 VEGA | MGI Sequence Detail 1291 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(8) UniProt(9)
Polymorphisms
SNPs within 2kb(118 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001610 PAC motif
InterPro IPR000014 PAS domain
InterPro IPR022728 Period circadian-like, C-terminal
Protein Ontology PR:000012547 period circadian protein homolog 1
References
(Earliest) J:20243 Ishida N, et al., Mouse hexamer repeat sequences homologous to the Drosophila 'period' gene. Nucleic Acids Res. 1988 Apr 25;16(8):3581
(Latest) J:219981 Gaddameedhi S, et al., The circadian clock controls sunburn apoptosis and erythema in mouse skin. J Invest Dermatol. 2015 Apr;135(4):1119-27
All references(161)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory