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Per1 Gene Detail
Summary
  • Symbol
    Per1
  • Name
    period circadian clock 1
  • Synonyms
    Hftm, mPer1, m-rigui
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098283
    NCBI Gene: 18626
  • Gene Overview
    MyGene.info: PER1
Location & Maps
more
  • Sequence Map
    Chr11:69095217-69109960 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14744 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.37 cM, cytoband B
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PER1, period circadian clock 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PER1, period circadian clock 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hPER, PER, RIGUI
  • Links
    NCBI Gene ID: 5187
    neXtProt AC: NX_O15534

  • Chr Location
    17p13.1; chr17:8140470-8156405 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Per1 mouse models

Human Disease Mouse Models
       Attention Deficit-Hyperactivity Disorder; ADHD   OMIM: 143465 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 4 alleles in 8 genetic backgrounds
    14 phenotypes from multigenic genotypes
    75 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    12
  • Targeted
    4
  • Transgenic
    1
  • Genomic Mutations
    1 involving Per1
  • Incidental Mutations
Homozygous null mice display a persistent circadian rhythm, but they have a shorter period and their ability to maintain the precision and the stability of the period is impaired.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005970 VEGA Gene Model | MGI Sequence Detail 14744 C57BL/6J ±  kb
transcript OTTMUST00000013334 VEGA | MGI Sequence Detail 4671 Not Applicable  
polypeptide OTTMUSP00000006173 VEGA | MGI Sequence Detail 1291 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    117 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 69
    Genomic 1
    cDNA 65
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGI:3522286
References
more
  • Summaries
    All 169
    Developmental Gene Expression 17
    Diseases 1
    Gene Ontology 27
    Phenotypes 75
  • Earliest
    J:20243 Ishida N, et al., Mouse hexamer repeat sequences homologous to the Drosophila 'period' gene. Nucleic Acids Res. 1988 Apr 25;16(8):3581
  • Latest
    J:229126 Xia L, et al., Daily variation in global and local DNA methylation in mouse livers. PLoS One. 2015;10(2):e0118101

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory