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C9 Gene Detail
Summary
  • Symbol
    C9
  • Name
    complement component 9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098282
    NCBI Gene: 12279
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:6445333-6498476 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 2.79 cM, cytoband A1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    150 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098282
protein coding gene Chr15:6445327-6498751 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021696
protein coding gene Chr15:3414586-3473123 (+)
A/J MGP_AJ_G0021657
protein coding gene Chr15:3365677-3420358 (+)
AKR/J MGP_AKRJ_G0021635
protein coding gene Chr15:3375900-3431218 (+)
BALB/cJ MGP_BALBcJ_G0021664
protein coding gene Chr15:3284009-3337211 (+)
C3H/HeJ MGP_C3HHeJ_G0021440
protein coding gene Chr15:3403406-3459958 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022103
protein coding gene Chr15:3570404-3626978 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019640
protein coding gene Chr15:3029881-3080992 (+)
CAST/EiJ MGP_CASTEiJ_G0020956
protein coding gene Chr15:3383886-3441028 (+)
CBA/J MGP_CBAJ_G0021409
protein coding gene Chr15:3625339-3688095 (+)
DBA/2J MGP_DBA2J_G0021533
protein coding gene Chr15:3301499-3353858 (+)
FVB/NJ MGP_FVBNJ_G0021511
protein coding gene Chr15:3221508-3273288 (+)
LP/J MGP_LPJ_G0021601
protein coding gene Chr15:3346098-3401937 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021536
protein coding gene Chr15:3835966-3895933 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022126
protein coding gene Chr15:3397408-3452474 (+)
PWK/PhJ MGP_PWKPhJ_G0020699
protein coding gene Chr15:3297730-3353654 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020537
protein coding gene Chr15:3319624-3377624 (+)
WSB/EiJ MGP_WSBEiJ_G0021012
protein coding gene Chr15:3314479-3369417 (+)



Homology
more
  • Human Ortholog
    C9, complement C9
  • Vertebrate Orthologs
    8
  • Human Ortholog
    C9, complement C9
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARMD15, C9D
  • Links
    NCBI Gene ID: 735
    neXtProt AC: NX_P02748
    UniProt: P02748

  • Chr Location
    5p13.1; chr5:39284275-39364553 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 74406
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: C9
  • Gene Tree
    C9
Human Diseases
more
  • Diseases
    2 with human C9 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12279 NCBI Gene Model | MGI Sequence Detail 53144 C57BL/6J ±  kb
    transcript NM_001368421 RefSeq | MGI Sequence Detail 2263 C57BL/6  
    polypeptide P06683 UniProt | EBI | MGI Sequence Detail 548 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • PDB
    • InterPro Domains
      IPR037567 Complement component C9
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR036055 LDL receptor-like superfamily
      IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
      IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
      IPR001862 Membrane attack complex component/perforin/complement C9
      IPR020863 Membrane attack complex component/perforin domain, conserved site
      IPR020864 Membrane attack complex component/perforin (MACPF) domain
      IPR000884 Thrombospondin type-1 (TSP1) repeat
      IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 24

      Microarray probesets 3
    References
    more
    • Summaries
      All 24
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 6
    • Earliest
      J:43388 Stanley KK, et al., Topological mapping of complement component C9 by recombinant DNA techniques suggests a novel mechanism for its insertion into target membranes. EMBO J. 1987 Jul;6(7):1951-7
    • Latest
      J:264658 Riley SP, et al., Immunity against the Obligate Intracellular Bacterial Pathogen Rickettsia australis Requires a Functional Complement System. Infect Immun. 2018 Jun;86(6)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory