Gse1 Gene Detail

Summary

• Symbol
  Gse1
• Name
  genetic suppressor element 1, coiled-coil protein
• Synonyms
  mKIAA0182

• Feature Type
  protein coding gene
• IDs
  MGI:1098275
  NCBI Gene: 382034
• Gene Overview
  MyGene.info: GSE1
• Alliance
  gene page
• Transcription Start Sites
  17 TSS

Location &
Maps

• Sequence Map
  Chr8:120228827-120581383 bp, + strand
• From NCBI annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 8, 69.69 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  800 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098275	protein coding gene	Chr8:120228456-120581390 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0034200	protein coding gene	Chr8:123628725-124013769 (+)
A/J	MGP_AJ_G0034180	protein coding gene	Chr8:118506275-118863665 (+)
AKR/J	MGP_AKRJ_G0034107	protein coding gene	Chr8:121942926-122313526 (+)
BALB/cJ	MGP_BALBcJ_G0034174	protein coding gene	Chr8:118717603-119079052 (+)
C3H/HeJ	MGP_C3HHeJ_G0033885	protein coding gene	Chr8:122676886-123054986 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034694	protein coding gene	Chr8:127741785-128136091 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031636	protein coding gene	Chr8:111385625-111739967 (+)
CAST/EiJ	MGP_CASTEiJ_G0033212	protein coding gene	Chr8:122659954-123051785 (+)
CBA/J	MGP_CBAJ_G0033858	protein coding gene	Chr8:132414059-132822775 (+)
DBA/2J	MGP_DBA2J_G0034014	protein coding gene	Chr8:117725841-118082736 (+)
FVB/NJ	MGP_FVBNJ_G0033957	protein coding gene	Chr8:116785345-117155409 (+)
LP/J	MGP_LPJ_G0034103	protein coding gene	Chr8:123760246-124134396 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034004	protein coding gene	Chr8:134812483-135189238 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034712	protein coding gene	Chr8:122110061-122488618 (+)
PWK/PhJ	MGP_PWKPhJ_G0032914	protein coding gene	Chr8:117498235-117860438 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032754	protein coding gene	Chr8:120804637-121190967 (+)
WSB/EiJ	MGP_WSBEiJ_G0033328	protein coding gene	Chr8:122846562-123226781 (+)

Homology

• Human Ortholog
  GSE1, Gse1 coiled-coil protein

• Vertebrate Orthologs
  10

• Human Ortholog
  GSE1, Gse1 coiled-coil protein
  Orthology source: HomoloGene, HGNC
• Synonyms
  CRHSP24, KIAA0182
• Links
  HGNC:28979

  NCBI Gene ID: 23199

  neXtProt AC: NX_Q14687

  UniProt: Q14687

  
  
• Chr Location
  16q24.1; chr16:85169512-85676206 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 40964
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: GSE1
• Gene Tree
  Gse1
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotypes from 1 allele in 1 genetic background
  3 phenotype references
  

• All Mutations and Alleles
  2
• Targeted
  2
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  235 strains or lines available

Gene Ontology
(GO)
Classifications

• External Resources
  FuncBase

Expression

• cDNA Data
  11
• Literature Summary
  2

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Interactions

• Gse1 interacts with 337 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

Sequences &
Gene Models

• All Sequences
  64
• RefSeq
  16
• UniProt
  2
• CCDS
  CCDS52687.1, CCDS52688.1, CCDS52689.1

• Ensembl
  ENSMUSG00000031822 (Evidence)
• NCBI Gene
  382034

Representative Sequences			Length	Strain/Species
genomic	382034	NCBI Gene Model | MGI Sequence Detail	352557	C57BL/6J
transcript	NM_198671	RefSeq | MGI Sequence Detail	6716	C57BL/6
polypeptide	Q3U3C9	UniProt | EBI | MGI Sequence Detail	1213	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000008283 genetic suppressor element 1
  (term hierarchy)
• InterPro Domains
  IPR022207 Genetic suppressor element-like

Molecular
Reagents

• All nucleic 11

  cDNA 11

  
  

  Microarray probesets 5

References

• Summaries
  All 24

  Developmental Gene Expression 2

  Phenotypes 3
• Earliest
  J:43245 Gudkov AV, et al., Cloning mammalian genes by expression selection of genetic suppressor elements: association of kinesin with drug resistance and cell immortalization. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3744-8
• Latest
  J:239715 Galazo MJ, et al., Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity. Neuron. 2016 Jul 06;91(1):90-106

TSS for Gse1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79756	Chr8:120488179-120488200 (+)	259,363 bp
Tssr79757	Chr8:120488206-120488225 (+)	259,389 bp
Tssr79758	Chr8:120488232-120488241 (+)	259,410 bp
Tssr79759	Chr8:120488416-120488490 (+)	259,626 bp
Tssr79760	Chr8:120488491-120488510 (+)	259,674 bp
Tssr79761	Chr8:120488542-120488569 (+)	259,729 bp
Tssr79762	Chr8:120488730-120488748 (+)	259,912 bp
Tssr79763	Chr8:120488752-120488803 (+)	259,951 bp
Tssr79764	Chr8:120488821-120488840 (+)	260,004 bp
Tssr79765	Chr8:120489053-120489067 (+)	260,233 bp
Tssr79769	Chr8:120535723-120535734 (+)	306,902 bp
Tssr79770	Chr8:120535789-120535867 (+)	307,001 bp
Tssr79772	Chr8:120537363-120537393 (+)	308,551 bp
Tssr79773	Chr8:120537423-120537445 (+)	308,607 bp
Tssr79774	Chr8:120537447-120537471 (+)	308,632 bp
Tssr79775	Chr8:120537472-120537501 (+)	308,660 bp
Tssr79776	Chr8:120537505-120537512 (+)	308,682 bp