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Amacr
Gene Detail
Symbol

Name
ID
Amacr
alpha-methylacyl-CoA racemase
MGI:1098273
Synonyms
2-arylpropionyl-CoA epimerase, Macr1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
5.39 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:10981756-10996624 bp, + strand
From NCBI annotation of GRCm38

  14869 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7410  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Amacr

Human
homologs
Human Homolog AMACR, alpha-methylacyl-CoA racemase
NCBI Gene ID 23600
neXtProt AC  NX_Q9UHK6
Human Synonyms  AMACRD, CBAS4, RACE, RM
Human Chr (Location)  5p13; chr5:33986986-34008115 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human AMACR
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display impaired bile acid synthesis and with dietary phytol supplementation develop liver degeneration and induced mortality.
 
Human Diseases Modeled Using Mouse Amacr (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Amacr interacts with 189 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process bile acid biosynthetic process, bile acid metabolic process, ...
Component cytoplasm, mitochondrion, ...
Function alpha-methylacyl-CoA racemase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (149)    Tissues (114)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 149
cDNA source data(48)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(50) Genomic(1) cDNA(48) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000022244 (Evidence)
Entrez Gene17117 (Evidence)
UniGene2787
DFCITC1577719
DoTSDT.50317140
NIA Mouse Gene IndexU016080
EC5.1.99.4
Consensus CDS ProjectCCDS27381.1
International Mouse Knockout Project StatusAmacr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17117 NCBI Gene Model | MGI Sequence Detail 14869 C57BL/6J ±  kb
transcript NM_008537 RefSeq | MGI Sequence Detail 2575 C57BL/6 
polypeptide O09174 UniProt | EBI | MGI Sequence Detail 381 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(177 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003673 CoA-transferase family III
InterPro IPR023606 CoA-transferase family III domain
Protein Ontology PR:000003984 alpha-methylacyl-CoA racemase
Graphical View of Protein Domain Structure
References
(Earliest) J:43000 Schmitz W, et al., Molecular cloning of cDNA species for rat and mouse liver alpha-methylacyl-CoA racemases. Biochem J. 1997 Sep 15;326(Pt 3):883-9
(Latest) J:213609 Autio KJ, et al., Role of AMACR (alpha-methylacyl-CoA racemase) and MFE-1 (peroxisomal multifunctional enzyme-1) in bile acid synthesis in mice. Biochem J. 2014 Jul 1;461(1):125-35
All references(37)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory