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Amacr Gene Detail
Summary
  • Symbol
    Amacr
  • Name
    alpha-methylacyl-CoA racemase
  • Synonyms
    2-arylpropionyl-CoA epimerase, Macr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098273
    NCBI Gene: 17117
  • Gene Overview
    MyGene.info: AMACR
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr15:10981756-10996624 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      14869 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 5.39 cM, cytoband B1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    AMACR, alpha-methylacyl-CoA racemase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AMACR, alpha-methylacyl-CoA racemase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AMACRD, CBAS4, P504S, RACE, RM
  • Links
    NCBI Gene ID: 23600
    neXtProt AC: NX_Q9UHK6
    UniProt: Q9UHK6

  • Chr Location
    5p13.2; chr5:33986986-34008115 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 7410
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AMACR
  • Gene Tree
    Amacr
Human Diseases
more
  • Diseases
    1 with Amacr mouse models; 2 with human AMACR associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display impaired bile acid synthesis and with dietary phytol supplementation develop liver degeneration and induced mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    149
  • Tissues
    114
  • cDNA Data
    49
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17117 NCBI Gene Model | MGI Sequence Detail 14869 C57BL/6J ±  kb
    transcript NM_008537 RefSeq | MGI Sequence Detail 2575 C57BL/6  
    polypeptide O09174 UniProt | EBI | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      177 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      Genomic 1
      cDNA 49
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 7
      Phenotypes 5
    • Earliest
      J:43000 Schmitz W, et al., Molecular cloning of cDNA species for rat and mouse liver alpha-methylacyl-CoA racemases. Biochem J. 1997 Sep 15;326(Pt 3):883-9
    • Latest
      J:246089 Tafferner N, et al., Alpha-methylacyl-CoA racemase deletion has mutually counteracting effects on T-cell responses, associated with unchanged course of EAE. Eur J Immunol. 2016 Mar;46(3):570-81
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/11/2018
    MGI 6.12     		The Jackson Laboratory