Amacr
Gene Detail

Symbol Name ID

Amacr alpha-methylacyl-CoA racemase MGI:1098273

Synonyms

2-arylpropionyl-CoA epimerase, Macr1

Feature Type

protein coding gene

Genetic Map

Chromosome 15

5.39 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:10981756-10996624 bp, + strand From NCBI annotation of GRCm38   14869 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7410  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Amacr

Human homologs

Human Homolog		AMACR, alpha-methylacyl-CoA racemase
NCBI Gene ID		23600
neXtProt AC		NX_Q9UHK6
Human Synonyms		AMACRD, CBAS4, RACE, RM
Human Chr (Location)		5p13; chr5:33986986-34008115 (-)  GRCh38
Disease Associations		(2) Diseases Associated with Human AMACR

Mutations, alleles, and phenotypes

All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous null mice display impaired bile acid synthesis and with dietary phytol supplementation develop liver degeneration and induced mortality.

 
Human Diseases Modeled Using Mouse Amacr (1)    Alleles Annotated to Human Diseases(1)   

Interactions

Amacr interacts with 189 markers (Mir15a, Mir15b, Mir16-1, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	bile acid biosynthetic process, bile acid metabolic process, ...
Component	cytoplasm, mitochondrion, ...
Function	alpha-methylacyl-CoA racemase activity, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)

Data Summary: Results (149)    Tissues (114)    Images (18)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	149

cDNA source data(48)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(50) Genomic(1) cDNA(48) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000022244 (Evidence)
Entrez Gene	17117 (Evidence)
UniGene	2787
DFCI	TC1577719
DoTS	DT.50317140
NIA Mouse Gene Index	U016080
EC	5.1.99.4
Consensus CDS Project	CCDS27381.1
International Mouse Knockout Project Status	Amacr

Sequences

Length	Strain/Species
genomic	17117	NCBI Gene Model | MGI Sequence Detail	14869	C57BL/6J
transcript	NM_008537	RefSeq | MGI Sequence Detail	2575	C57BL/6
polypeptide	O09174	UniProt | EBI | MGI Sequence Detail	381	Not Applicable

All sequences(18) RefSeq(2) UniProt(3)

Polymorphisms

SNPs within 2kb(177 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR003673	CoA-transferase family III
InterPro	IPR023606	CoA-transferase family III domain
Protein Ontology	PR:000003984	alpha-methylacyl-CoA racemase

Graphical View of Protein Domain Structure

References

(Earliest) J:43000 Schmitz W, et al., Molecular cloning of cDNA species for rat and mouse liver alpha-methylacyl-CoA racemases. Biochem J. 1997 Sep 15;326(Pt 3):883-9
(Latest) J:202515 Selkala EM, et al., Metabolic adaptation allows Amacr-deficient mice to remain symptom-free despite low levels of mature bile acids. Biochim Biophys Acta. 2013 Aug;1831(8):1335-43
All references(36)
Disease annotation references (1)