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Amacr Gene Detail
Summary
  • Symbol
    Amacr
  • Name
    alpha-methylacyl-CoA racemase
  • Synonyms
    2-arylpropionyl-CoA epimerase, Macr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098273
    NCBI Gene: 17117
  • Gene Overview
    MyGene.info: AMACR
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:10981756-10996624 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 5.39 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    177 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098273
 protein coding gene Chr15:10981756-10996626 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021727
 protein coding gene Chr15:8135796-8166064 (+)
A/J MGP_AJ_G0021687
 protein coding gene Chr15:7908315-7923267 (+)
AKR/J MGP_AKRJ_G0021665
 protein coding gene Chr15:8098968-8120032 (+)
BALB/cJ MGP_BALBcJ_G0021694
 protein coding gene Chr15:7811912-7827452 (+)
C3H/HeJ MGP_C3HHeJ_G0021470
 protein coding gene Chr15:8055552-8075686 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022133
 protein coding gene Chr15:8455013-8473058 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019670
 protein coding gene Chr15:7381481-7396186 (+)
CAST/EiJ MGP_CASTEiJ_G0020986
 protein coding gene Chr15:8113326-8131926 (+)
CBA/J MGP_CBAJ_G0021439
 protein coding gene Chr15:8654806-8673292 (+)
DBA/2J MGP_DBA2J_G0021563
 protein coding gene Chr15:7775723-7790316 (+)
FVB/NJ MGP_FVBNJ_G0021541
 protein coding gene Chr15:7630651-7645317 (+)
LP/J MGP_LPJ_G0021631
 protein coding gene Chr15:8053988-8070172 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021566
 protein coding gene Chr15:8914765-8931210 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022156
 protein coding gene Chr15:8083479-8099324 (+)
PWK/PhJ MGP_PWKPhJ_G0020729
 protein coding gene Chr15:7946227-7962795 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020567
 protein coding gene Chr15:8031076-8047917 (+)
WSB/EiJ MGP_WSBEiJ_G0021042
 protein coding gene Chr15:8065608-8080216 (+)



Homology
more
  • Human Ortholog
    AMACR, alpha-methylacyl-CoA racemase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AMACR, alpha-methylacyl-CoA racemase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AMACRD, CBAS4, P504S, RACE, RM
  • Links
    NCBI Gene ID: 23600
    neXtProt AC: NX_Q9UHK6
    UniProt: Q9UHK6

  • Chr Location
    5p13.2; chr5:33986986-34008115 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 7410
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AMACR
  • Gene Tree
    Amacr
Human Diseases
more
  • Diseases
    1 with Amacr mouse models; 2 with human AMACR associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display impaired bile acid synthesis and with dietary phytol supplementation develop liver degeneration and induced mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    149
  • Tissues
    114
  • cDNA Data
    49
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17117 NCBI Gene Model | MGI Sequence Detail 14869 C57BL/6J ±  kb
    transcript NM_008537 RefSeq | MGI Sequence Detail 2575 C57BL/6  
    polypeptide O09174 UniProt | EBI | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      Genomic 1
      cDNA 49
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 7
      Phenotypes 5
    • Earliest
      J:43000 Schmitz W, et al., Molecular cloning of cDNA species for rat and mouse liver alpha-methylacyl-CoA racemases. Biochem J. 1997 Sep 15;326(Pt 3):883-9
    • Latest
      J:246089 Tafferner N, et al., Alpha-methylacyl-CoA racemase deletion has mutually counteracting effects on T-cell responses, associated with unchanged course of EAE. Eur J Immunol. 2016 Mar;46(3):570-81
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/08/2019
    MGI 6.14     		The Jackson Laboratory