Ogdh
Gene Detail

Symbol Name ID

Ogdh oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) MGI:1098267

Synonyms

2210403E04Rik, 2210412K19Rik, alpha-ketoglutarate dehydrogenase, d1401

Feature Type

protein coding gene

Genetic Map

Chromosome 11

3.94 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr11:6291633-6356642 bp, + strand From VEGA annotation of GRCm38   65010 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; pig, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Ogdh ± 2 cM)

Protein SuperFamily: 2-oxoglutarate dehydrogenase, E1 component
Gene Tree: Ogdh

Human ortholog

OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) NCBI Gene ID 4967
Human Synonyms: AKGDH, E1k, OGDC
Human Chr7:44646121-44748669 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human OGDH (1)

Alleles and phenotypes

All alleles(40) : Targeted(2) Gene trapped(38)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	2-oxoglutarate metabolic process, glycolysis, ...
Component	mitochondrion, oxoglutarate dehydrogenase complex
Function	chaperone binding, heat shock protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (174)    Tissues (129)    Images (21)
Theiler Stages: 22, 26, 28

Assay Type	Results
RNA in situ	154
RT-PCR	20

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(25) cDNA(22) Primer pair(2) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000000782 (Evidence)
Ensembl Gene Model	ENSMUSG00000020456 (Evidence)
Entrez Gene	18293 (Evidence)
DFCI	TC1573893, TC1586953, TC1588109, TC1591241, TC1603995, TC1622057, TC1636767, TC1682184, TC1695655, TC1720787, TC1732797
DoTS	DT.101174861, DT.101228425, DT.101234839, DT.101292665, DT.101292667, DT.101292669, DT.110502936, DT.110502963, DT.110502995, DT.110502997, DT.488974, DT.536871, DT.60104545, DT.94291431, DT.97389730
NIA Mouse Gene Index	U012294
EC	1.2.4.2
PDB	3TF7
Consensus CDS Project	CCDS36106.1, CCDS56758.1, CCDS56759.1
International Mouse Knockout Project Status	Ogdh

Sequences

Length	Strain/Species
genomic	OTTMUSG00000000782	VEGA Gene Model | MGI Sequence Detail	65010	C57BL/6J
transcript	OTTMUST00000001535	VEGA | MGI Sequence Detail	4075	Not Applicable
polypeptide	OTTMUSP00000000736	VEGA | MGI Sequence Detail	1034	Not Applicable

All sequences(130) RefSeq(10) UniProt(4)

Polymorphisms

SNPs(245 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011603	2-oxoglutarate dehydrogenase, E1 component
InterPro	IPR001017	Dehydrogenase, E1 component
InterPro	IPR005475	Transketolase-like, pyrimidine-binding domain
Protein Ontology	PR:000011612	2-oxoglutarate dehydrogenase, mitochondrial

References

(Earliest) J:43415 Udaka K, et al., A ubiquitous protein is the source of naturally occurring peptides that are recognized by a CD8+ T-cell clone. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11272-6
(Latest) J:188319 Gibson GE, et al., Deficits in the mitochondrial enzyme alpha-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation. Neurobiol Aging. 2012 Jun;33(6):1121.e13-24
All references(44)

Other accession IDs

MGI:1917392, MGI:1922924, MGI:2143998