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Ogdh
Gene Detail
Symbol

Name
ID
Ogdh
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
MGI:1098267
Synonyms
2210403E04Rik, 2210412K19Rik, alpha-ketoglutarate dehydrogenase, d1401
Feature Type
protein coding gene
Genetic Map
Chromosome 11
3.94 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:6291633-6356642 bp, + strand
From VEGA annotation of GRCm38

  65010 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55662  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: 2-oxoglutarate dehydrogenase, E1 component
Gene Tree: Ogdh

Human
homologs
Human Homolog OGDH, oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
NCBI Gene ID 4967
neXtProt AC  NX_Q02218
Human Synonyms  AKGDH, E1k, OGDC
Human Chr (Location)  7p14-p13; chr7:44606522-44709070 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human OGDH
Mutations,
alleles, and
phenotypes
All mutations/alleles(40) : Gene trapped(38) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Ogdh interacts with 164 markers (Mir10a, Mir10b, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process 2-oxoglutarate metabolic process, glycolytic process, ...
Component mitochondrion, oxoglutarate dehydrogenase complex
Function chaperone binding, heat shock protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (174)    Tissues (130)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 154
RT-PCR 20
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) cDNA(22) Primer pair(2) Other(1)
Microarray probesets(5)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000782 VEGA Gene Model | MGI Sequence Detail 65010 C57BL/6J ±  kb
transcript OTTMUST00000001535 VEGA | MGI Sequence Detail 4075 Not Applicable 
polypeptide OTTMUSP00000000736 VEGA | MGI Sequence Detail 1034 Not Applicable 

For the selected sequences
All sequences(141) RefSeq(20) UniProt(5)
Polymorphisms
SNPs within 2kb(278 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011603 2-oxoglutarate dehydrogenase, E1 component
InterPro IPR001017 Dehydrogenase, E1 component
InterPro IPR005475 Transketolase-like, pyrimidine-binding domain
Protein Ontology PR:000011612 2-oxoglutarate dehydrogenase, mitochondrial
References
(Earliest) J:43415 Udaka K, et al., A ubiquitous protein is the source of naturally occurring peptides that are recognized by a CD8+ T-cell clone. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11272-6
(Latest) J:188319 Gibson GE, et al., Deficits in the mitochondrial enzyme alpha-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation. Neurobiol Aging. 2012 Jun;33(6):1121.e13-24
All references(46)
Other
accession IDs
MGI:1917392, MGI:1922924, MGI:2143998

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory