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Ogdh
Gene Detail
 Symbol
Name
ID
Ogdh
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
MGI:1098267
Synonyms 2210403E04Rik, 2210412K19Rik, alpha-ketoglutarate dehydrogenase, d1401
Feature Type protein coding gene
Genetic Map
Chromosome 11
3.94 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:6291633-6356642 bp, + strand
From VEGA annotation of GRCm38

  65010 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55662  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: 2-oxoglutarate dehydrogenase, E1 component
Gene Tree: Ogdh

Human
homologs
Human Homolog OGDH, oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
NCBI Gene ID 4967
neXtProt AC  NX_Q02218
Human Synonyms  AKGDH, E1k, OGDC
Human Chr (Location)  7p14-p13; chr7:44606522-44709070 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human OGDH
Alleles
and
phenotypes
All alleles(40) : Targeted(2) Gene trapped(38)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process 2-oxoglutarate metabolic process, glycolytic process, ...
Component mitochondrion, oxoglutarate dehydrogenase complex
Function chaperone binding, heat shock protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (174)    Tissues (129)    Images (21)
Theiler Stages: 22, 26, 28
Assay TypeResults
RNA in situ 154
RT-PCR 20
cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(25) cDNA(22) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000000782 (Evidence)
Ensembl Gene ModelENSMUSG00000020456 (Evidence)
Entrez Gene18293 (Evidence)
DFCITC1573893, TC1586953, TC1588109, TC1591241, TC1603995, TC1622057, TC1636767, TC1682184, TC1695655, TC1720787, TC1732797
DoTSDT.101174861, DT.101228425, DT.101234839, DT.101292665, DT.101292667, DT.101292669, DT.110502936, DT.110502963, DT.110502995, DT.110502997, DT.488974, DT.536871, DT.60104545, DT.94291431, DT.97389730
NIA Mouse Gene IndexU012294
EC1.2.4.2
PDB3E2H, 3TF7
Consensus CDS ProjectCCDS36106.1, CCDS56758.1, CCDS56759.1
International Mouse Knockout Project StatusOgdh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000782 VEGA Gene Model | MGI Sequence Detail 65010 C57BL/6J ±  kb
transcript OTTMUST00000001535 VEGA | MGI Sequence Detail 4075 Not Applicable 
polypeptide OTTMUSP00000000736 VEGA | MGI Sequence Detail 1034 Not Applicable 

For the selected sequences
All sequences(140) RefSeq(20) UniProt(4)
Polymorphisms SNPs within 2kb(278 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011603 2-oxoglutarate dehydrogenase, E1 component
InterPro IPR001017 Dehydrogenase, E1 component
InterPro IPR005475 Transketolase-like, pyrimidine-binding domain
Protein Ontology PR:000011612 2-oxoglutarate dehydrogenase, mitochondrial
References (Earliest) J:43415 Udaka K, et al., A ubiquitous protein is the source of naturally occurring peptides that are recognized by a CD8+ T-cell clone. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11272-6
(Latest) J:188319 Gibson GE, et al., Deficits in the mitochondrial enzyme alpha-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation. Neurobiol Aging. 2012 Jun;33(6):1121.e13-24
All references(45)
Other
accession IDs
MGI:1917392, MGI:1922924, MGI:2143998

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory