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Ogdh Gene Detail
Summary
  • Symbol
    Ogdh
  • Name
    oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
  • Synonyms
    2210403E04Rik, 2210412K19Rik, alpha-ketoglutarate dehydrogenase, d1401
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098267
    NCBI Gene: 18293
  • Gene Overview
    MyGene.info: OGDH
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:6291633-6356642 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 3.94 cM, cytoband A1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    275 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098267
protein coding gene Chr11:6291597-6359094 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018020
protein coding gene Chr11:3392710-3462960 (+)
A/J MGP_AJ_G0017993
protein coding gene Chr11:3256690-3324493 (+)
AKR/J MGP_AKRJ_G0017957
protein coding gene Chr11:3417590-3486728 (+)
BALB/cJ MGP_BALBcJ_G0017961
protein coding gene Chr11:3263566-3330867 (+)
C3H/HeJ MGP_C3HHeJ_G0017774
protein coding gene Chr11:3289653-3356268 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018413
protein coding gene Chr11:3495594-3565583 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016071
protein coding gene Chr11:3149084-3213577 (+)
CAST/EiJ MGP_CASTEiJ_G0017336
protein coding gene Chr11:3269650-3339041 (+)
CBA/J MGP_CBAJ_G0017749
protein coding gene Chr11:3896136-3971207 (+)
DBA/2J MGP_DBA2J_G0017859
protein coding gene Chr11:3170518-3238280 (+)
FVB/NJ MGP_FVBNJ_G0017851
protein coding gene Chr11:3186230-3253987 (+)
LP/J MGP_LPJ_G0017930
protein coding gene Chr11:3471203-3544494 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017877
protein coding gene Chr11:3451655-3524495 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018453
protein coding gene Chr11:3430866-3497692 (+)
PWK/PhJ MGP_PWKPhJ_G0017116
protein coding gene Chr11:3199099-3266953 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016913
protein coding gene Chr11:3382984-3449411 (+)
WSB/EiJ MGP_WSBEiJ_G0017390
protein coding gene Chr11:3264074-3329253 (+)



Homology
more
  • Human Ortholog
    OGDH, oxoglutarate dehydrogenase
  • Vertebrate Orthologs
    11
  • Human Ortholog
    OGDH, oxoglutarate dehydrogenase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AKGDH, E1k, OGDC
  • Links
    NCBI Gene ID: 4967
    neXtProt AC: NX_Q02218
    UniProt: Q02218

  • Chr Location
    7p13; chr7:44606522-44709070 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020456 Ensembl Gene Model | MGI Sequence Detail 65010 C57BL/6J ±  kb
    transcript ENSMUST00000093350 Ensembl | MGI Sequence Detail 4075 Not Applicable  
    polypeptide ENSMUSP00000091041 Ensembl | MGI Sequence Detail 1034 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • PDB
    • EC
    • InterPro Domains
      IPR011603 2-oxoglutarate dehydrogenase E1 component
      IPR032106 2-oxoglutarate dehydrogenase E1 component, N-terminal domain
      IPR001017 Dehydrogenase, E1 component
      IPR031717 Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal
      IPR029061 Thiamin diphosphate-binding fold
      IPR005475 Transketolase-like, pyrimidine-binding domain
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 23
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1917392, MGI:1922924, MGI:2143998
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 7
      Gene Ontology 9
      Phenotypes 10
    • Earliest
      J:43415 Udaka K, et al., A ubiquitous protein is the source of naturally occurring peptides that are recognized by a CD8+ T-cell clone. Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):11272-6
    • Latest
      J:249661 Schatton D, et al., CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. J Cell Biol. 2017 Mar 06;216(3):675-693

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory