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Kif1c Gene Detail
Summary
  • Symbol
    Kif1c
  • Name
    kinesin family member 1C
  • Synonyms
    B430105J22Rik, D11Bwg1349e, N-3 kinsin, Orch3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098260
    NCBI Gene: 16562
  • Gene Overview
    MyGene.info: KIF1C
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:70700548-70731964 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 43.21 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    284 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098260
protein coding gene Chr11:70700323-70731970 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018614
protein coding gene Chr11:71251294-71285692 (+)
A/J MGP_AJ_G0018582
protein coding gene Chr11:68557567-68588926 (+)
AKR/J MGP_AKRJ_G0018551
protein coding gene Chr11:70613427-70644532 (+)
BALB/cJ MGP_BALBcJ_G0018554
protein coding gene Chr11:68864713-68896328 (+)
C3H/HeJ MGP_C3HHeJ_G0018367
protein coding gene Chr11:70634843-70667424 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019005
protein coding gene Chr11:73406795-73441849 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016650
protein coding gene Chr11:65461329-65493736 (+)
CAST/EiJ MGP_CASTEiJ_G0017922
protein coding gene Chr11:70906080-70939310 (+)
CBA/J MGP_CBAJ_G0018339
protein coding gene Chr11:76711499-76746044 (+)
DBA/2J MGP_DBA2J_G0018449
protein coding gene Chr11:68128188-68160121 (+)
FVB/NJ MGP_FVBNJ_G0018439
protein coding gene Chr11:67769930-67805481 (+)
LP/J MGP_LPJ_G0018519
protein coding gene Chr11:71828170-71861707 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018462
protein coding gene Chr11:77261045-77298737 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019047
protein coding gene Chr11:70872451-70903208 (+)
PWK/PhJ MGP_PWKPhJ_G0017696
protein coding gene Chr11:68775899-68951831 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017486
protein coding gene Chr11:70689120-70722328 (+)
WSB/EiJ MGP_WSBEiJ_G0017976
protein coding gene Chr11:70533555-70569297 (+)



Homology
more
  • Human Ortholog
    KIF1C, kinesin family member 1C
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KIF1C, kinesin family member 1C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LTXS1, SATX2, SAX2, SPAX2, SPG58
  • Links
    NCBI Gene ID: 10749
    neXtProt AC: NX_O43896
    UniProt: O43896

  • Chr Location
    17p13.2; chr17:4997948-5028399 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4821
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KIF1C
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human KIF1C associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 5 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele are viable, fertile and overtly normal and display normal motor-dependent retrograde Golgi apparatus-to-endoplasmic reticulum transport.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020821 Ensembl Gene Model | MGI Sequence Detail 31417 C57BL/6J ±  kb
    transcript ENSMUST00000072187 Ensembl | MGI Sequence Detail 5046 Not Applicable  
    polypeptide ENSMUSP00000072048 Ensembl | MGI Sequence Detail 1112 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 109
      cDNA 107
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-36568, MGI:106361, MGI:107988, MGI:1335095, MGI:2443544
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 17
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:195317 Blehm BH, et al., In vivo optical trapping indicates kinesin's stall force is reduced by dynein during intracellular transport. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3381-6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory