About   Help   FAQ
Capg Gene Detail
Summary
  • Symbol
    Capg
  • Name
    capping protein (actin filament), gelsolin-like
  • Synonyms
    gCap39, mbh1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098259
    NCBI Gene: 12332
  • Gene Overview
    MyGene.info: CAPG
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:72544391-72562983 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 32.27 cM, cytoband C3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    177 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098259
protein coding gene Chr6:72538282-72562983 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030879
protein coding gene Chr6:73113416-73132825 (+)
A/J MGP_AJ_G0030849
protein coding gene Chr6:70273117-70292216 (+)
AKR/J MGP_AKRJ_G0030778
protein coding gene Chr6:72340545-72359205 (+)
BALB/cJ MGP_BALBcJ_G0030860
protein coding gene Chr6:70298577-70317465 (+)
C3H/HeJ MGP_C3HHeJ_G0030852
protein coding gene Chr6:111878202-111898686 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031318
protein coding gene Chr6:75022571-75045444 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028507
protein coding gene Chr6:69409769-69429472 (+)
CAST/EiJ MGP_CASTEiJ_G0029968
protein coding gene Chr6:72212446-72231817 (+)
CBA/J MGP_CBAJ_G0030547
protein coding gene Chr6:78095209-78121337 (+)
DBA/2J MGP_DBA2J_G0030699
protein coding gene Chr6:69664438-69682759 (+)
FVB/NJ MGP_FVBNJ_G0030652
protein coding gene Chr6:69052375-69072383 (+)
LP/J MGP_LPJ_G0030778
protein coding gene Chr6:73015926-73035637 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030687
protein coding gene Chr6:81470082-81490490 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031344
protein coding gene Chr6:72166344-72186830 (+)
PWK/PhJ MGP_PWKPhJ_G0029684
protein coding gene Chr6:68578972-68598146 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029512
protein coding gene Chr6:70902620-70922834 (+)
WSB/EiJ MGP_WSBEiJ_G0030050
protein coding gene Chr6:72538115-72559749 (+)



Homology
more
  • Human Ortholog
    CAPG, capping actin protein, gelsolin like
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CAPG, capping actin protein, gelsolin like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AFCP, HEL-S-66, MCP
  • Links
    NCBI Gene ID: 822
    neXtProt AC: NX_P40121
    UniProt: P40121

  • Chr Location
    2p11.2; chr2:85394748-85418467 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37523
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CAPG
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Inactivation of this loci results in impaired immune cell motility which manifests in homozygous mutant mice as increased susceptibility to some bacterial infections.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056737 Ensembl Gene Model | MGI Sequence Detail 18593 C57BL/6J ±  kb
transcript ENSMUST00000071044 Ensembl | MGI Sequence Detail 1247 Not Applicable  
polypeptide ENSMUSP00000063389 Ensembl | MGI Sequence Detail 349 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 287
    cDNA 285
    Primer pair 2

    Microarray probesets 4
References
more
  • Summaries
    All 41
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:43520 Yu FX, et al., gCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein. Science. 1990 Dec 7;250(4986):1413-5
  • Latest
    J:221550 Abonnenc M, et al., Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ Res. 2013 Oct 25;113(10):1138-47

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory