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Capg
Gene Detail
Symbol

Name
ID
Capg
capping protein (actin filament), gelsolin-like
MGI:1098259
Synonyms
gCap39, mbh1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
32.27 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:72544391-72562983 bp, + strand
From VEGA annotation of GRCm38

  18593 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37523  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: severin
Gene Tree: Capg

Human
homologs
Human Homolog CAPG, capping protein (actin filament), gelsolin-like
NCBI Gene ID 822
neXtProt AC  NX_P40121
Human Synonyms  AFCP, HEL-S-66, MCP
Human Chr (Location)  2p11.2; chr2:85394748-85414074 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(20) : Gene trapped(17) Targeted(3)
 
Inactivation of this loci results in impaired immune cell motility which manifests in homozygous mutant mice as increased susceptibility to some bacterial infections.
 
Interactions
Capg interacts with 17 markers (Mir1a-1, Mir1a-2, Mir137, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process actin filament capping, cell projection assembly
Component cytoplasm, extracellular region, ...
Function actin binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (160)    Tissues (73)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 158
RT-PCR 2
cDNA source data(284)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(286) cDNA(284) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022323 (Evidence)
Ensembl Gene ModelENSMUSG00000056737 (Evidence)
Entrez Gene12332 (Evidence)
UniGene18626
DFCITC1677489, TC1630590, TC1572230
NIA Mouse Gene IndexU007040
Consensus CDS ProjectCCDS39516.1
International Mouse Knockout Project StatusCapg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022323 VEGA Gene Model | MGI Sequence Detail 18593 C57BL/6J ±  kb
transcript OTTMUST00000053199 VEGA | MGI Sequence Detail 1247 Not Applicable 
polypeptide OTTMUSP00000025284 VEGA | MGI Sequence Detail 349 Not Applicable 

For the selected sequences
All sequences(90) RefSeq(12) UniProt(17)
Polymorphisms
SNPs within 2kb(175 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007123 Gelsolin domain
InterPro IPR007122 Villin/Gelsolin
Protein Ontology PR:000005008 macrophage-capping protein
References
(Earliest) J:43520 Yu FX, et al., gCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein. Science. 1990 Dec 7;250(4986):1413-5
(Latest) J:171050 Thiagarajan RD, et al., Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. PLoS One. 2011;6(2):e17286
All references(42)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory