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Kif15 Gene Detail
Summary
  • Symbol
    Kif15
  • Name
    kinesin family member 15
  • Synonyms
    3110023M17Rik, 3930402I10Rik, HKLP2, Knsl7, N-10 kinesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098258
    NCBI Gene: 209737
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:122780146-122847798 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 73.31 cM, cytoband F4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1676 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098258
 protein coding gene Chr9:122780111-122847798 (+)
129S1/SvImJ ENSMUSG00200027937
 protein coding gene Chr9:119934536-119957810 (+)
129S1/SvImJ ENSMUSGG00200054540
 protein coding gene Chr9:119907772-119932460 (+)
A/J ENSMUSGG00195054979
 protein coding gene Chr9:119047524-119072553 (+)
A/J ENSMUSG00195025906
 protein coding gene Chr9:119074629-119097925 (+)
AKR/J ENSMUSG00220018671
 protein coding gene Chr9:119546094-119569363 (+)
AKR/J ENSMUSGG00220054897
 protein coding gene Chr9:119519326-119544017 (+)
BALB/cJ ENSMUSGG00180055201
 protein coding gene Chr9:119587357-119612385 (+)
BALB/cJ ENSMUSG00180025092
 protein coding gene Chr9:119614461-119637750 (+)
C3H/HeJ ENSMUSG00175017679
 protein coding gene Chr9:119850811-119874107 (+)
C3H/HeJ ENSMUSGG00175054912
 protein coding gene Chr9:119823710-119848735 (+)
C57BL/6NJ ENSMUSGG00215055320
 protein coding gene Chr9:119742893-119767584 (+)
C57BL/6NJ ENSMUSG00215015064
 protein coding gene Chr9:119769660-119792927 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032850
 protein coding gene Chr9:118280439-118349535 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054710
 protein coding gene Chr9:119547557-119572243 (+)
CBA/J ENSMUSG00210034606
 protein coding gene Chr9:119574319-119597586 (+)
DBA/2J ENSMUSGG00185057480
 protein coding gene Chr9:119883211-119907897 (+)
DBA/2J ENSMUSG00185015125
 protein coding gene Chr9:119909973-119933240 (+)
FVB/NJ ENSMUSGG00205054110
 protein coding gene Chr9:119714090-119739112 (+)
FVB/NJ ENSMUSG00205022205
 protein coding gene Chr9:119741188-119764488 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055513
 protein coding gene Chr9:120047920-120072607 (+)
LP/J ENSMUSG00230034470
 protein coding gene Chr9:120074683-120097954 (+)
NOD/ShiLtJ ENSMUSGG00190054552
 protein coding gene Chr9:119490801-119515489 (+)
NOD/ShiLtJ ENSMUSG00190014398
 protein coding gene Chr9:119517565-119540832 (+)
NZO/HlLtJ ENSMUSGG00225055317
 protein coding gene Chr9:120308238-120332925 (+)
NZO/HlLtJ ENSMUSG00225023504
 protein coding gene Chr9:120335001-120358272 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010021868
 protein coding gene Chr9:121297990-121367817 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    KIF15, kinesin family member 15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KIF15, kinesin family member 15
  • Synonyms
    BRDCS2, HKLP2, KLP2, KNSL7, NY-BR-62
  • Links
    NCBI Gene ID: 56992
    UniProt: Q9NS87

  • Chr Location
    3p21.31; chr3:44761721-44873376 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit inhibited growth of transplanted tumor cells with increased CD8+ T cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    731
  • Tissues
    133
  • cDNA Data
    78
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 209737 NCBI Gene Model | MGI Sequence Detail 67653 C57BL/6J ±  kb
    transcript NM_010620 RefSeq | MGI Sequence Detail 4840 C57BL/6  
    polypeptide Q6P9L6 UniProt | EBI | MGI Sequence Detail 1387 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000009289 kinesin-like protein KIF15
      (term hierarchy)
    • InterPro Domains
      IPR031794 Hyaluronan-mediated motility receptor, C-terminal
      IPR044986 Kinesin-like protein KIF15/KIN-12
      IPR001752 Kinesin motor domain
      IPR036961 Kinesin motor domain superfamily
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      Q6P9L6 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 85
      cDNA 81
      Primer pair 2
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1918015, MGI:1920396, MGI:5437723
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 7
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:18490 Winter H, et al., Sequence and expression of murine type I hair keratins mHa2 and mHa3. Exp Cell Res. 1994 Jun;212(2):190-200
    • Latest
      J:387856 Murlanova K, et al., NPAS3-regulated astrocyte mitochondrial bioenergetics is required for cognition. Sci Adv. 2026 Jun 19;12(25):eadt2527
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory