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Ap1s1
Gene Detail
Symbol

Name
ID
Ap1s1
adaptor protein complex AP-1, sigma 1
MGI:1098244
Synonyms
AP19
Feature Type
protein coding gene
Genetic Map
Chromosome 5
76.13 cM, cytoband G1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:137034993-137046135 bp, - strand
From VEGA annotation of GRCm38

  11143 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20342  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: adaptor protein complex, sigma subunit
Gene Tree: Ap1s1

Human
homologs
Human Homolog AP1S1, adaptor-related protein complex 1, sigma 1 subunit
NCBI Gene ID 1174
neXtProt AC  NX_P61966
Human Synonyms  AP19, CLAPS1, EKV3, MEDNIK, SIGMA1A, WUGSC:H_DJ0747G18.2
Human Chr (Location)  7q22.1; chr7:101154405-101161276 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human AP1S1
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(14) Targeted(4)
Incidental mutations (data from APF )
Interactions
Ap1s1 interacts with 122 markers (Mir1a-1, Mir1a-2, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process intracellular protein transport, protein transport, ...
Component AP-1 adaptor complex, coated pit, ...
Function protein binding, protein transporter activity
External Resources: FuncBase
Expression
cDNA source data(134)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(134) cDNA(134)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023414 (Evidence)
Ensembl Gene ModelENSMUSG00000004849 (Evidence)
Entrez Gene11769 (Evidence)
UniGene833
DFCITC1573521
DoTSDT.101382184, DT.101382174, DT.87072944
NIA Mouse Gene IndexU152749, U026837
PDB1W63
Consensus CDS ProjectCCDS39330.1
International Mouse Knockout Project StatusAp1s1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023414 VEGA Gene Model | MGI Sequence Detail 11143 C57BL/6J ±  kb
transcript OTTMUST00000056875 VEGA | MGI Sequence Detail 748 Not Applicable 
polypeptide OTTMUSP00000027387 VEGA | MGI Sequence Detail 189 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(6) UniProt(7)
Polymorphisms
SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016635 Adaptor protein complex, sigma subunit
InterPro IPR022775 AP complex, mu/sigma subunit
InterPro IPR000804 Clathrin adaptor complex, small chain
InterPro IPR011012 Longin-like domain
Protein Ontology PR:000004096 AP-1 complex subunit sigma-1A
References
(Earliest) J:43399 Kirchhausen T, et al., AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast. J Biol Chem. 1991 Jun 15;266(17):11153-7
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory