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Ap1s1 Gene Detail
Summary
  • Symbol
    Ap1s1
  • Name
    adaptor protein complex AP-1, sigma 1
  • Synonyms
    AP19
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098244
    NCBI Gene: 11769
  • Gene Overview
    MyGene.info: AP1S1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:137034993-137046060 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 76.13 cM, cytoband G1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098244
protein coding gene Chr5:137034993-137046135 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030215
protein coding gene Chr5:141754864-141765966 (-)
A/J MGP_AJ_G0030183
protein coding gene Chr5:135608092-135619194 (-)
AKR/J MGP_AKRJ_G0030116
protein coding gene Chr5:139999686-140010736 (-)
BALB/cJ MGP_BALBcJ_G0030193
protein coding gene Chr5:136966932-136978033 (-)
C3H/HeJ MGP_C3HHeJ_G0029909
protein coding gene Chr5:140626438-140637538 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030645
protein coding gene Chr5:147023434-147034576 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027865
protein coding gene Chr5:129877526-129888671 (-)
CAST/EiJ MGP_CASTEiJ_G0029319
protein coding gene Chr5:140040177-140051284 (-)
CBA/J MGP_CBAJ_G0029879
protein coding gene Chr5:152770912-152782014 (-)
DBA/2J MGP_DBA2J_G0030030
protein coding gene Chr5:135504113-135515216 (-)
FVB/NJ MGP_FVBNJ_G0029985
protein coding gene Chr5:134684303-134695405 (-)
LP/J MGP_LPJ_G0030119
protein coding gene Chr5:142183087-142194342 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030017
protein coding gene Chr5:155667407-155678509 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030686
protein coding gene Chr5:139832811-139843912 (-)
PWK/PhJ MGP_PWKPhJ_G0029032
protein coding gene Chr5:134594013-134605283 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028868
protein coding gene Chr5:137417780-137433241 (-)
WSB/EiJ MGP_WSBEiJ_G0029392
protein coding gene Chr5:140575477-140586490 (-)



Homology
more
  • Human Ortholog
    AP1S1, adaptor related protein complex 1 subunit sigma 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    AP1S1, adaptor related protein complex 1 subunit sigma 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AP19, CLAPS1, EKV3, MEDNIK, SIGMA1A
  • Links
    NCBI Gene ID: 1174
    neXtProt AC: NX_P61966
    UniProt: P61966

  • Chr Location
    7q22.1; chr7:101154405-101161276 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human AP1S1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 11769 NCBI Gene Model | MGI Sequence Detail 11068 C57BL/6J ±  kb
transcript NM_007457 RefSeq | MGI Sequence Detail 1350 C57BL/6  
polypeptide P61967 UniProt | EBI | MGI Sequence Detail 158 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • PDB
  • InterPro Domains
    IPR016635 Adaptor protein complex, sigma subunit
    IPR022775 AP complex, mu/sigma subunit
    IPR000804 Clathrin adaptor complex, small chain
    IPR011012 Longin-like domain superfamily
Molecular
Reagents
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  • All nucleic 135
    cDNA 135

    Microarray probesets 3
References
more
  • Summaries
    All 37
    Gene Ontology 8
    Phenotypes 8
  • Earliest
    J:43399 Kirchhausen T, et al., AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast. J Biol Chem. 1991 Jun 15;266(17):11153-7
  • Latest
    J:216244 Baltes J, et al., sigma1B adaptin regulates adipogenesis by mediating the sorting of sortilin in adipose tissue. J Cell Sci. 2014 Aug 15;127(Pt 16):3477-87

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory