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Ap1s1
Gene Detail
Symbol

Name
ID
Ap1s1
adaptor protein complex AP-1, sigma 1
MGI:1098244
Synonyms
AP19
Feature Type
protein coding gene
Genetic Map
Chromosome 5
76.13 cM, cytoband G1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:137034993-137046135 bp, - strand
From VEGA annotation of GRCm38

  11143 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20342  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AP1S1
Protein SuperFamily: adaptor protein complex, sigma subunit
Gene Tree: Ap1s1

Human
homologs
AP1S1, adaptor-related protein complex 1, sigma 1 subunit
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 1174
neXtProt AC: NX_P61966

Human Synonyms: AP19, CLAPS1, EKV3, MEDNIK, SIGMA1A

Human Chr (Location): 7q22.1; chr7:101154405-101161276 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human AP1S1

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(14) Targeted(4)
Incidental mutations (data from APF )
Interactions
Ap1s1 interacts with 122 markers (Mir1a-1, Mir1a-2, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process intracellular protein transport, protein transport, ...
Component AP-1 adaptor complex, cell, ...
Function protein binding, protein transporter activity
External Resources: FuncBase
Expression
cDNA source data(134)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ap1s1    NEW 
Molecular
reagents
All nucleic(134) cDNA(134)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000023414 (Evidence)
Ensembl Gene Model ENSMUSG00000004849 (Evidence)
Entrez Gene 11769 (Evidence)
UniGene 833
DFCI TC1573521
DoTS DT.101382184, DT.101382174, DT.87072944
NIA Mouse Gene Index U026837, U152749
PDB 1W63
Consensus CDS Project CCDS39330.1
International Mouse Phenotyping Consortium Status Ap1s1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023414 VEGA Gene Model | MGI Sequence Detail 11143 C57BL/6J ±  kb
transcript OTTMUST00000056875 VEGA | MGI Sequence Detail 748 Not Applicable 
polypeptide OTTMUSP00000027387 VEGA | MGI Sequence Detail 189 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016635 Adaptor protein complex, sigma subunit
InterPro IPR022775 AP complex, mu/sigma subunit
InterPro IPR000804 Clathrin adaptor complex, small chain
InterPro IPR011012 Longin-like domain
Protein Ontology PR:000004096 AP-1 complex subunit sigma-1A
References
(Earliest) J:43399 Kirchhausen T, et al., AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast. J Biol Chem. 1991 Jun 15;266(17):11153-7
(Latest) J:216244 Baltes J, et al., sigma1B adaptin regulates adipogenesis by mediating the sorting of sortilin in adipose tissue. J Cell Sci. 2014 Aug 15;127(Pt 16):3477-87
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory