Ap1s1
Gene Detail

Symbol Name ID

Ap1s1 adaptor protein complex AP-1, sigma 1 MGI:1098244

Synonyms

AP19

Feature Type

protein coding gene

Genetic Map

Chromosome 5

76.13 cM, cytoband G1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:137034993-137046135 bp, - strand From VEGA annotation of GRCm38   11143 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20342  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Protein SuperFamily: adaptor protein complex, sigma subunit
Gene Tree: Ap1s1

Human homologs

Human Homolog		AP1S1, adaptor-related protein complex 1, sigma 1 subunit
NCBI Gene ID		1174
neXtProt AC		NX_P61966
Human Synonyms		AP19, CLAPS1, MEDNIK, SIGMA1A, WUGSC:H_DJ0747G18.2
Human Chr (Location)		7q22.1; chr7:100797686-100804557 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human AP1S1

Alleles and phenotypes

All alleles(17) : Targeted(3) Gene trapped(14)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	endocytosis, intracellular protein transport, ...
Component	AP-1 adaptor complex, coated pit, ...
Function	protein binding, protein transporter activity

External Resources: FuncBase

Expression

cDNA source data(133)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(133) cDNA(133)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000023414 (Evidence)
Ensembl Gene Model	ENSMUSG00000004849 (Evidence)
Entrez Gene	11769 (Evidence)
UniGene	833
DFCI	TC1573521
DoTS	DT.101382174, DT.101382184, DT.87072944
NIA Mouse Gene Index	U026837, U152749
PDB	1W63
Consensus CDS Project	CCDS39330.1
International Mouse Knockout Project Status	Ap1s1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023414	VEGA Gene Model | MGI Sequence Detail	11143	C57BL/6J
transcript	OTTMUST00000056875	VEGA | MGI Sequence Detail	748	Not Applicable
polypeptide	OTTMUSP00000027387	VEGA | MGI Sequence Detail	189	Not Applicable

All sequences(42) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(4 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016635	Adaptor protein complex, sigma subunit
InterPro	IPR022775	AP complex, mu/sigma subunit
InterPro	IPR000804	Clathrin adaptor complex, small chain
InterPro	IPR011012	Longin-like domain
Protein Ontology	PR:000004096	AP-1 complex subunit sigma-1A

References

(Earliest) J:43399 Kirchhausen T, et al., AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast. J Biol Chem. 1991 Jun 15;266(17):11153-7
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(38)