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Kif16b Gene Detail
Summary
  • Symbol
    Kif16b
  • Name
    kinesin family member 16B
  • Synonyms
    8430434E15Rik, mKIAA1590, N-3 kinesin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098240
    NCBI Gene: 16558
  • Gene Overview
    MyGene.info: KIF16B
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:142618340-142901594 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 70.67 cM, cytoband G3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2455 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098240
protein coding gene Chr2:142617474-142901594 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026573
protein coding gene Chr2:146613379-146906608 (-)
A/J MGP_AJ_G0026537
protein coding gene Chr2:140662956-140947948 (-)
AKR/J MGP_AKRJ_G0026511
protein coding gene Chr2:144732616-145024083 (-)
BALB/cJ MGP_BALBcJ_G0026549
protein coding gene Chr2:141134018-141416383 (-)
C3H/HeJ MGP_C3HHeJ_G0026292
protein coding gene Chr2:145274947-145566239 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026994
protein coding gene Chr2:151020261-151328883 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024371
protein coding gene Chr2:134955870-135229533 (-)
CAST/EiJ MGP_CASTEiJ_G0025753
protein coding gene Chr2:145617380-145907633 (-)
CBA/J MGP_CBAJ_G0026272
protein coding gene Chr2:156561364-156867980 (-)
DBA/2J MGP_DBA2J_G0026406
protein coding gene Chr2:140018368-140292920 (-)
FVB/NJ MGP_FVBNJ_G0026370
protein coding gene Chr2:138573903-138852953 (-)
LP/J MGP_LPJ_G0026510
protein coding gene Chr2:146792289-147089751 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026390
protein coding gene Chr2:160775094-161077407 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027049
protein coding gene Chr2:144745753-145031718 (-)
PWK/PhJ MGP_PWKPhJ_G0025489
protein coding gene Chr2:139653093-139935118 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025290
protein coding gene Chr2:143785245-144092459 (-)
WSB/EiJ MGP_WSBEiJ_G0025826
protein coding gene Chr2:145730292-146022259 (-)



Homology
more
  • Human Ortholog
    KIF16B, kinesin family member 16B
  • Vertebrate Orthologs
    6
  • Human Ortholog
    KIF16B, kinesin family member 16B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C20orf23, KISC20ORF, SNX23
  • Links
    NCBI Gene ID: 55614
    neXtProt AC: NX_Q96L93
    UniProt: Q96L93

  • Chr Location
    20p12.1; chr20:16272104-16573457 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Chimera embryos containing a knock-out allele and derived from tetraploid rescue exhibit lethal growth arrest at the blastocyst stage with abnormal development of the primitive endoderm, epiblast epithelium, and basement membrane.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16558 NCBI Gene Model | MGI Sequence Detail 283255 C57BL/6J ±  kb
transcript NM_001355123 RefSeq | MGI Sequence Detail 5478 C57BL/6  
polypeptide B1AVY7 UniProt | EBI | MGI Sequence Detail 1312 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 6
Other
Accession IDs
less
MGI:1918790, MGI:2139053, MGI:2139499, MGI:2139511, MGI:3034217
References
more
  • Summaries
    All 42
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:221337 Farkhondeh A, et al., Characterizing KIF16B in neurons reveals a novel intramolecular "stalk inhibition" mechanism that regulates its capacity to potentiate the selective somatodendritic localization of early endosomes. J Neurosci. 2015 Mar 25;35(12):5067-86

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory