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Kif7
Gene Detail
 Symbol
Name
ID
Kif7
kinesin family member 7
MGI:1098239
Feature Type protein coding gene
Genetic Map
Chromosome 7
45.09 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:79698098-79715720 bp, - strand
From VEGA annotation of GRCm38

  17623 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:72555  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Kif7

Human
homologs
Human Homolog KIF7, kinesin family member 7
NCBI Gene ID 374654
neXtProt AC  NX_Q2M1P5
Human Synonyms  ACLS, HLS2, JBTS12, UNQ340
Human Chr (Location)  15q26.1; chr15:89617944-89655494 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human KIF7
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Chemically induced (ENU)(3) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit neonatal lethality, exencephaly, polydactyly, abnormal sternum, edema, abnormal ribs, and abnormal neurogenesis. Mice homozygous for an ENU-induced allele exhibit prenatal lethality, polydactyly, and abnormal neural tube development and neurogenesis.
 
Human Diseases Modeled Using Mouse Kif7 (3)    Alleles Annotated to Human Diseases(2)    Phenotype Images(27)
Interactions
Kif7 interacts with 85 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process ATP catabolic process, metabolic process, ...
Component cell projection, cilium, ...
Function ATPase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (12)    Tissues (12)   
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
Northern blot 12
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) cDNA(9)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000044965 (Evidence)
Ensembl Gene ModelENSMUSG00000050382 (Evidence)
Entrez Gene16576 (Evidence)
NIA Mouse Gene IndexU028745
Consensus CDS ProjectCCDS52278.1
International Mouse Knockout Project StatusKif7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044965 VEGA Gene Model | MGI Sequence Detail 17623 C57BL/6J ±  kb
transcript OTTMUST00000118173 VEGA | MGI Sequence Detail 4577 Not Applicable 
polypeptide OTTMUSP00000065977 VEGA | MGI Sequence Detail 1348 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(18) UniProt(4)
Polymorphisms SNPs within 2kb(151 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001752 Kinesin, motor domain
InterPro IPR019821 Kinesin, motor region, conserved site
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000009320 kinesin-like protein KIF7
References (Earliest) J:18490 Winter H, et al., Sequence and expression of murine type I hair keratins mHa2 and mHa3. Exp Cell Res. 1994 Jun;212(2):190-200
(Latest) J:197449 Coles GL, et al., Kif7 is required for the patterning and differentiation of the diaphragm in a model of syndromic congenital diaphragmatic hernia. Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1898-905
All references(35)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory