Kif7
Gene Detail

Symbol Name ID

Kif7 kinesin family member 7 MGI:1098239

Feature Type

protein coding gene

Genetic Map

Chromosome 7

45.09 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr7:79698099-79714186 bp, - strand From Ensembl annotation of GRCm38   16088 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Kif7 ± 2 cM)

Gene Tree: Kif7

Human ortholog

KIF7 kinesin family member 7 NCBI Gene ID 374654
Human Synonyms: ACLS, HLS2, JBTS12, UNQ340
Human Chr15:90171201-90198682 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human KIF7 (2)

Alleles and phenotypes

All alleles(4) : Targeted(3) Chemically induced(1)
 

Mice homozygous for a knock-out allele exhibit neonatal lethality, exencephaly, polydactyly, abnormal sternum, edema, abnormal ribs, and abnormal neurogenesis. Mice homozygous for an ENU-induced allele exhibit prenatal lethality, polydactyly, and abnormal neural tube development and neurogenesis.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	microtubule-based movement, negative regulation of smoothened signaling pathway, ...
Component	cell projection, cilium, ...
Function	ATP binding, microtubule motor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (12)    Tissues (12)   
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
Northern blot	12

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) cDNA(9)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000050382 (Evidence)
Entrez Gene	16576 (Evidence)
NIA Mouse Gene Index	U028745
Consensus CDS Project	CCDS52278.1
International Mouse Knockout Project Status	Kif7

Sequences

Length	Strain/Species
genomic	ENSMUSG00000050382	Ensembl Gene Model | MGI Sequence Detail	16088	C57BL/6J
transcript	ENSMUST00000178048	Ensembl | MGI Sequence Detail	4524	Not Applicable
polypeptide	ENSMUSP00000136993	Ensembl | MGI Sequence Detail	1348	Not Applicable

All sequences(23) RefSeq(2) UniProt(4)

Protein-related information

Resource	ID	Description
InterPro	IPR001752	Kinesin, motor domain
InterPro	IPR019821	Kinesin, motor region, conserved site
Protein Ontology	PR:000009320	kinesin-like protein KIF7

References

(Earliest) J:18490 Winter H, et al., Sequence and expression of murine type I hair keratins mHa2 and mHa3. Exp Cell Res. 1994 Jun;212(2):190-200
(Latest) J:192138 Hsu SH, et al., Suppressor of fused (Sufu) mediates the effect of parathyroid hormone-like hormone (Pthlh) on chondrocyte differentiation in the growth plate. J Biol Chem. 2012 Oct 19;287(43):36222-8
All references(31)