About   Help   FAQ
Kif7 Gene Detail
Summary
  • Symbol
    Kif7
  • Name
    kinesin family member 7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098239
    NCBI Gene: 16576
Location & Maps
more
  • Sequence Map
    Chr7:79698098-79715720 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17623 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 45.09 cM, cytoband D2
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    KIF7, kinesin family member 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KIF7, kinesin family member 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACLS, AGBK, HLS2, JBTS12, UNQ340
  • Links
    NCBI Gene ID: 374654
    neXtProt AC: NX_Q2M1P5

  • Chr Location
    15q26.1; chr15:89608913-89663074 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with Kif7 mouse models; 3 with human KIF7 associations

Human Disease Mouse Models
       Acrocallosal Syndrome; ACLS   OMIM: 200990 View 1 model
Hydrolethalus Syndrome 2; HLS2   OMIM: 614120 View 1 model
       Diaphragmatic Hernia, Congenital   OMIM: 142340 View 1 model
       Al-Gazali-Bakalinova Syndrome; AGBK   OMIM: 607131
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 5 alleles in 6 genetic backgrounds
    9 phenotypes from multigenic genotypes
    27 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (ENU)
    3
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    3 involving Kif7
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit neonatal lethality, exencephaly, polydactyly, abnormal sternum, edema, abnormal ribs, and abnormal neurogenesis. Mice homozygous for an ENU-induced allele exhibit prenatal lethality, polydactyly, and abnormal neural tube development and neurogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044965 VEGA Gene Model | MGI Sequence Detail 17623 C57BL/6J ±  kb
transcript OTTMUST00000118173 VEGA | MGI Sequence Detail 4577 Not Applicable  
polypeptide OTTMUSP00000065977 VEGA | MGI Sequence Detail 1348 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    150 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000009320 kinesin-like protein KIF7
  • InterPro Domains
    IPR027640 Kinesin-like protein
    IPR001752 Kinesin motor domain
    IPR019821 Kinesin motor domain, conserved site
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 3
References
more
  • Summaries
    All 39
    Developmental Gene Expression 7
    Diseases 2
    Gene Ontology 8
    Phenotypes 24
  • Earliest
    J:18490 Winter H, et al., Sequence and expression of murine type I hair keratins mHa2 and mHa3. Exp Cell Res. 1994 Jun;212(2):190-200
  • Latest
    J:229412 Stephen LA, et al., TALPID3 controls centrosome and cell polarity and the human ortholog KIAA0586 is mutated in Joubert syndrome (JBTS23). Elife. 2015;4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/23/2016
MGI 6.05
The Jackson Laboratory