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Kif7 Gene Detail
Summary
  • Symbol
    Kif7
  • Name
    kinesin family member 7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098239
    NCBI Gene: 16576
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:79698098-79715720 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17623 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 45.09 cM, cytoband D2
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    KIF7, kinesin family member 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KIF7, kinesin family member 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACLS, AGBK, HLS2, JBTS12, UNQ340
  • Links
    NCBI Gene ID: 374654
    neXtProt AC: NX_Q2M1P5
    UniProt: Q2M1P5

  • Chr Location
    15q26.1; chr15:89627970-89663086 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    4 with Kif7 mouse models; 2 with human KIF7 associations

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
      
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 5 alleles in 6 genetic backgrounds
    9 phenotypes from multigenic genotypes
    27 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neonatal lethality, exencephaly, polydactyly, abnormal sternum, edema, abnormal ribs, and abnormal neurogenesis. Mice homozygous for an ENU-induced allele exhibit prenatal lethality, polydactyly, and abnormal neural tube development and neurogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000044965 VEGA Gene Model | MGI Sequence Detail 17623 C57BL/6J ±  kb
    transcript OTTMUST00000118173 VEGA | MGI Sequence Detail 4577 Not Applicable  
    polypeptide OTTMUSP00000065977 VEGA | MGI Sequence Detail 1348 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      150 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR027640 Kinesin-like protein
      IPR001752 Kinesin motor domain
      IPR019821 Kinesin motor domain, conserved site
      IPR036961 Kinesin motor domain superfamily
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 3
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 10
      Phenotypes 26
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:244712 Navarro N, et al., Does 3D Phenotyping Yield Substantial Insights in the Genetics of the Mouse Mandible Shape?. G3 (Bethesda). 2016 May 03;6(5):1153-63

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory