Kif6 MGI Mouse Gene Detail - MGI:1098238

Symbol

Kif6
Name

kinesin family member 6
Synonyms

D130004B10Rik, D130084M03Rik

Feature Type

protein coding gene
IDs

MGI:1098238
NCBI Gene: 319991
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr17:49922164-50216875 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 25.78 cM, cytoband C
Mapping Data

3 experiments

SNPs within 2kb

8975 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098238	protein coding gene	Chr17:49922121-50216875 (+)
129S1/SvImJ	ENSMUSG00200027982	protein coding gene	Chr17:45126866-45421924 (+)
A/J	ENSMUSG00195021894	protein coding gene	Chr17:46614702-46909326 (+)
AKR/J	ENSMUSG00220030100	protein coding gene	Chr17:45614699-45909348 (+)
BALB/cJ	ENSMUSG00180022841	protein coding gene	Chr17:46370974-46665597 (+)
C3H/HeJ	ENSMUSG00175015133	protein coding gene	Chr17:45678444-45973035 (+)
C57BL/6NJ	ENSMUSG00215029741	protein coding gene	Chr17:45247011-45541862 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021733	protein coding gene	Chr17:46347746-46639496 (+)
CAST/EiJ	ENSTCUG00005024190	protein coding gene	Chr17:46417106-46717849 (+)
CBA/J	ENSMUSG00210028984	protein coding gene	Chr17:45427994-45722589 (+)
DBA/2J	ENSMUSG00185027307	protein coding gene	Chr17:48327086-48621701 (+)
FVB/NJ	ENSMUSG00205051185	protein coding gene	Chr17:45899027-46196952 (+)
JF1/MsJ	ENSUMUG00000024681	protein coding gene	Chr17:48018280-48312272 (+)
LP/J	ENSMUSG00230037010	protein coding gene	Chr17:49238391-49533424 (+)
NOD/ShiLtJ	ENSMUSG00190014853	protein coding gene	Chr17:45403166-45702636 (+)
NZO/HlLtJ	ENSMUSG00225041584	protein coding gene	Chr17:51476367-51768705 (+)
PWK/PhJ	ENSLUMG00010028449	protein coding gene	Chr17:45249242-45542740 (+)
SPRET/EiJ	ENSMSPG00010033139	protein coding gene	Chr17:45455640-45749007 (+)
WSB/EiJ	ENSIUOG00005027077	protein coding gene	Chr17:46280110-46578602 (+)

Human Ortholog

KIF6, kinesin family member 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KIF6, kinesin family member 6
Synonyms

C6orf102, dJ1043E3.1, dJ137F1.4, dJ188D3.1
Links

HGNC:21202

NCBI Gene ID: 221458

UniProt: Q6ZMV9
Chr Location

6p21.2; chr6:39329990-39725408 (-) GRCh38

MGI Vertebrate Homology

Kif6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KIF6
Gene Tree

Kif6

Diseases

7 with human KIF6 associations

				Human Disease	Mouse Models
				acute myocardial infarction IDs acute myocardial infarction DOID:9408 ICD10CM:I21 ICD9CM:410 ICD9CM:410.9 ICD9CM:410.90 NCI:C35204 UMLS_CUI:C0155626
				aortic dissection IDs aortic dissection DOID:0080685
				coronary artery disease IDs coronary artery disease DOID:3393 DOID:10506 DOID:3363 DOID:3394 DOID:9420 EFO:0001645 ICD10CM:I20-I25 ICD10CM:I25 ICD10CM:I25.10 ICD9CM:410-414.99 ICD9CM:414.0 ICD9CM:414.9 MESH:D003324 MESH:D003327 MESH:D017202 NCI:C35505 NCI:C50625 OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293 UMLS_CUI:C0010054 UMLS_CUI:C0010068 UMLS_CUI:C0151744 UMLS_CUI:C0264694
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538
				myocardial infarction IDs myocardial infarction DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051
				stroke IDs stroke DOID:0051061
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

22 phenotypes from 4 alleles in 4 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (ENU)

1
Endonuclease-mediated

5
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozgyos for an ENU-induced allele exhibit normal exercise capacity and cardiac function. Mice homozygous for a knock-out allele exhibit premature death, hydrocephaly, dilated brain ventricles and defective ependymal cell cilia formation.

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All GO Annotations

19
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

629
Tissues

2
cDNA Data

9
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kif6

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All Sequences

52
RefSeq

10
UniProt

5
CCDS

CCDS50144.1

Ensembl

ENSMUSG00000023999 (Evidence)
NCBI Gene

319991

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023999	Ensembl Gene Model \| MGI Sequence Detail	294712	C57BL/6J	± kb
transcript	ENSMUST00000162854	Ensembl \| MGI Sequence Detail	3528	Not Applicable
polypeptide	ENSMUSP00000124674	Ensembl \| MGI Sequence Detail	802	Not Applicable

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UniProt

5 Sequences
InterPro Domains

IPR027640 Kinesin-like protein

IPR056524 Kinesin-like protein KIF6/9, C-terminal

IPR001752 Kinesin motor domain

IPR019821 Kinesin motor domain, conserved site

IPR036961 Kinesin motor domain superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 9

cDNA 9

Microarray probesets 5

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MGI:2443122, MGI:3045267

Summaries

All 41

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 12
Earliest

J:18490 Winter H, et al., Sequence and expression of murine type I hair keratins mHa2 and mHa3. Exp Cell Res. 1994 Jun;212(2):190-200
Latest

J:390224 Xie C, et al., The KIF6-RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly. Adv Sci (Weinh). 2026 Jun 25;:e76263

TSS for Kif6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr145134	Chr17:49922132-49922179 (+)	-8 bp
Tssr5157	Chr17:50045760-50045773 (+)	123,603 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24