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Impact Gene Detail
Summary
  • Symbol
    Impact
  • Name
    impact, RWD domain protein
  • Synonyms
    E430016J11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098233
    NCBI Gene: 16210
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:12962942-12992950 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 6.87 cM, cytoband A2-B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    166 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098233
protein coding gene Chr18:12955852-12992950 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024164
protein coding gene Chr18:10194809-10217146 (+)
A/J MGP_AJ_G0024126
protein coding gene Chr18:9982050-10003435 (+)
AKR/J MGP_AKRJ_G0024093
protein coding gene Chr18:10287345-10308224 (+)
BALB/cJ MGP_BALBcJ_G0024125
protein coding gene Chr18:9940261-9963106 (+)
C3H/HeJ MGP_C3HHeJ_G0023892
protein coding gene Chr18:10172744-10194448 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024570
protein coding gene Chr18:10693830-10716127 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022010
protein coding gene Chr18:9549116-9570290 (+)
CAST/EiJ MGP_CASTEiJ_G0023369
protein coding gene Chr18:10072108-10093682 (+)
CBA/J MGP_CBAJ_G0023864
protein coding gene Chr18:10847712-10873527 (+)
DBA/2J MGP_DBA2J_G0023993
protein coding gene Chr18:9816975-9838952 (+)
FVB/NJ MGP_FVBNJ_G0023958
protein coding gene Chr18:9692968-9713748 (+)
LP/J MGP_LPJ_G0024076
protein coding gene Chr18:10276425-10298960 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023987
protein coding gene Chr18:10982313-11003463 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024616
protein coding gene Chr18:10049461-10070137 (+)
PWK/PhJ MGP_PWKPhJ_G0023115
protein coding gene Chr18:9902483-9924131 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022924
protein coding gene Chr18:10331625-10353640 (+)
WSB/EiJ MGP_WSBEiJ_G0023435
protein coding gene Chr18:10060650-10082203 (+)



Homology
more
  • Human Ortholog
    IMPACT, impact RWD domain protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IMPACT, impact RWD domain protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RWDD5
  • Links
    NCBI Gene ID: 55364
    neXtProt AC: NX_Q9P2X3
    UniProt: Q9P2X3

  • Chr Location
    18q11.2; chr18:24426645-24453531 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 5490
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: IMPACT
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16210 NCBI Gene Model | MGI Sequence Detail 30009 C57BL/6J ±  kb
transcript NM_008378 RefSeq | MGI Sequence Detail 3779 C57BL/6  
polypeptide O55091 UniProt | EBI | MGI Sequence Detail 318 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 98
    cDNA 96
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:2442038
References
more
  • Summaries
    All 41
    Developmental Gene Expression 12
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:42447 Hagiwara Y, et al., Screening for imprinted genes by allelic message display: identification of a paternally expressed gene impact on mouse chromosome 18. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9249-54
  • Latest
    J:211861 Cambiaghi TD, et al., Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2. Biochem Biophys Res Commun. 2014 Jan 10;443(2):592-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory