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Kif11
Gene Detail
 Symbol
Name
ID
Kif11
kinesin family member 11
MGI:1098231
Synonyms Eg5, Kifl1, Knsl1
Feature Type protein coding gene
Genetic Map
Chromosome 19
32.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr19:37376403-37421859 bp, + strand
From NCBI annotation of GRCm38

  45457 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3322  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: KIP1-like kinesin
Gene Tree: Kif11

Human
homologs
Human Homolog KIF11, kinesin family member 11
NCBI Gene ID 3832
neXtProt AC  NX_P52732
Human Synonyms  EG5, HKSP, KNSL1, MCLMR, TRIP5
Human Chr (Location)  10q24.1; chr10:92593068-92655395 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human KIF11
Alleles
and
phenotypes
All alleles(48) : Targeted(3) Gene trapped(45)
 
Deletion of Kif11 results in early embryonic lethality of homozygotes, with developmental growth arrest at E3.5.
 
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, cytoskeleton, ...
Function ATP binding, microtubule binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (94)    Tissues (94)    Images (20)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(187)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(195) Genomic(4) cDNA(189) Primer pair(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000012443 (Evidence)
Entrez Gene16551 (Evidence)
UniGene42203
DFCITC1573076
DoTSDT.50317004
NIA Mouse Gene IndexU019412
Consensus CDS ProjectCCDS29777.1
International Mouse Knockout Project StatusKif11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16551 NCBI Gene Model | MGI Sequence Detail 45457 C57BL/6J ±  kb
transcript NM_010615 RefSeq | MGI Sequence Detail 4850 C57BL/6 
polypeptide Q6P9P6 UniProt | EBI | MGI Sequence Detail 1052 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(2)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(187 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025901 Kinesin-associated microtubule-binding domain
InterPro IPR001752 Kinesin, motor domain
InterPro IPR019821 Kinesin, motor region, conserved site
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000003045 kinesin-like protein KIF11
Graphical View of Protein Domain Structure
References (Earliest) J:18490 Winter H, et al., Sequence and expression of murine type I hair keratins mHa2 and mHa3. Exp Cell Res. 1994 Jun;212(2):190-200
(Latest) J:197286 Gable A, et al., Dynamic reorganization of Eg5 in the mammalian spindle throughout mitosis requires dynein and TPX2. Mol Biol Cell. 2012 Apr;23(7):1254-66
All references(49)
Other
accession IDs
MGI:1306820

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory