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Kif11 Gene Detail
Summary
  • Symbol
    Kif11
  • Name
    kinesin family member 11
  • Synonyms
    Eg5, Kifl1, Knsl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098231
    NCBI Gene: 16551
  • Gene Overview
    MyGene.info: KIF11
Location & Maps
more
  • Sequence Map
    Chr19:37376403-37421859 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      45457 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 32.27 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    KIF11, kinesin family member 11
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KIF11, kinesin family member 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EG5, HKSP, KNSL1, MCLMR, TRIP5
  • Links
    NCBI Gene ID: 3832
    neXtProt AC: NX_P52732

  • Chr Location
    10q23.33; chr10:92593068-92655395 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human KIF11 associations

Human Disease Mouse Models
       Microcephaly with or without Chorioretinopathy, Lymphedema, or Mental Retardation; MCLMR   OMIM: 152950
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Deletion of Kif11 results in early embryonic lethality of homozygotes, with developmental growth arrest at E3.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16551 NCBI Gene Model | MGI Sequence Detail 45457 C57BL/6J ±  kb
transcript NM_010615 RefSeq | MGI Sequence Detail 4850 C57BL/6  
polypeptide Q6P9P6 UniProt | EBI | MGI Sequence Detail 1052 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    186 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 195
    Genomic 4
    cDNA 189
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
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MGI:1306820
References
more
  • Summaries
    All 51
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:18490 Winter H, et al., Sequence and expression of murine type I hair keratins mHa2 and mHa3. Exp Cell Res. 1994 Jun;212(2):190-200
  • Latest
    J:236331 Kovacovicova K, et al., In Vitro Maturation of Mouse Oocytes Increases the Level of Kif11/Eg5 on Meiosis II Spindles. Biol Reprod. 2016 Jul;95(1):18

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory