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Gamt Gene Detail
Summary
  • Symbol
    Gamt
  • Name
    guanidinoacetate methyltransferase
  • Synonyms
    Spintz1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098221
    NCBI Gene: 14431
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:80258151-80261012 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098221
protein coding gene Chr10:80258151-80261026 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017491
protein coding gene Chr10:80855451-80858312 (-)
A/J MGP_AJ_G0017469
protein coding gene Chr10:78022236-78025097 (-)
AKR/J MGP_AKRJ_G0017430
protein coding gene Chr10:80153691-80156552 (-)
BALB/cJ MGP_BALBcJ_G0017431
protein coding gene Chr10:78253558-78256419 (-)
C3H/HeJ MGP_C3HHeJ_G0017254
protein coding gene Chr10:80250171-80253032 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017885
protein coding gene Chr10:83644271-83647132 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015573
protein coding gene Chr10:74245167-74247928 (-)
CAST/EiJ MGP_CASTEiJ_G0016821
protein coding gene Chr10:80455009-80457837 (-)
CBA/J MGP_CBAJ_G0017226
protein coding gene Chr10:86885110-86887971 (-)
DBA/2J MGP_DBA2J_G0017332
protein coding gene Chr10:77243160-77246021 (-)
FVB/NJ MGP_FVBNJ_G0017326
protein coding gene Chr10:76428285-76431146 (-)
LP/J MGP_LPJ_G0017403
protein coding gene Chr10:81328132-81330993 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017352
protein coding gene Chr10:88829046-88831907 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017926
protein coding gene Chr10:80139999-80142860 (-)
PWK/PhJ MGP_PWKPhJ_G0016602
protein coding gene Chr10:77110689-77113513 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016391
protein coding gene Chr10:79120903-79123735 (-)
WSB/EiJ MGP_WSBEiJ_G0016881
protein coding gene Chr10:80176116-80178977 (-)



Homology
more
  • Human Ortholog
    GAMT, guanidinoacetate N-methyltransferase
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GAMT, guanidinoacetate N-methyltransferase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CCDS2, HEL-S-20, PIG2, TP53I2
  • Links
    NCBI Gene ID: 2593
    neXtProt AC: NX_Q14353
    UniProt: Q14353

  • Chr Location
    19p13.3; chr19:1397026-1401570 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Gamt mouse models; 1 with human GAMT associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display increased postnatal lethality; reduced body weight, muscle tension, and creatine concentrations; infertility with impaired spermatogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020150 Ensembl Gene Model | MGI Sequence Detail 2862 C57BL/6J ±  kb
    transcript ENSMUST00000020359 Ensembl | MGI Sequence Detail 979 Not Applicable  
    polypeptide ENSMUSP00000020359 Ensembl | MGI Sequence Detail 252 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      Genomic 1
      cDNA 71
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143491
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 6
      Phenotypes 19
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:257429 Tachikawa M, et al., Cell-Type-Specific Spatiotemporal Expression of Creatine Biosynthetic Enzyme S-adenosylmethionine:guanidinoacetate N-methyltransferase in Developing Mouse Brain. Neurochem Res. 2018 Feb;43(2):500-510

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory