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Hmgb3
Gene Detail
 Symbol
Name
ID
Hmgb3
high mobility group box 3
MGI:1098219
Synonyms Hmg2a, Hmg4
Feature Type protein coding gene
Genetic Map
Chromosome X
36.92 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:71555918-71560676 bp, + strand
From VEGA annotation of GRCm38

  4759 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:134266  Vertebrate Homology Class
1 mouse; 2 rat; 1 chimpanzee; 2 zebrafish

Gene Tree: Hmgb3

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
 
Homozygous null mice display increased red cell numbers, hematocrit, and hemaglobin content, and decreased mean red cell volume and common myeloid and lymphoid progenitors.
 
Interactions
Hmgb3 interacts with 227 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process negative regulation of B cell differentiation, negative regulation of myeloid cell differentiation
Component chromosome, nucleus
Function DNA binding
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (199)    Tissues (156)    Images (17)
Theiler Stages: 17, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 190
Northern blot 6
RT-PCR 3
cDNA source data(170)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(178) Genomic(4) cDNA(171) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000017794 (Evidence)
Ensembl Gene ModelENSMUSG00000015217 (Evidence)
Entrez Gene15354 (Evidence)
UniGene336087
DFCITC1571918, TC1629107
DoTSDT.101310796, DT.101409761, DT.101738082, DT.102542171, DT.536554, DT.94277708, DT.99871474
NIA Mouse Gene IndexU019917, U055573
Consensus CDS ProjectCCDS30180.1
International Mouse Knockout Project StatusHmgb3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017794 VEGA Gene Model | MGI Sequence Detail 4759 C57BL/6J ±  kb
transcript OTTMUST00000043056 VEGA | MGI Sequence Detail 1571 Not Applicable 
polypeptide OTTMUSP00000019352 VEGA | MGI Sequence Detail 200 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(14) UniProt(3)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
InterPro IPR017967 HMG box A DNA-binding domain, conserved site
Protein Ontology PR:000008632 high mobility group protein B3
References (Earliest) J:43286 Wilke K, et al., Isolation of human and mouse HMG2a cDNAs: evidence for an HMG2a-specific 3' untranslated region. Gene. 1997 Oct 1;198(1-2):269-74
(Latest) J:171293 Campbell GR, et al., Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling. Mol Cell Neurosci. 2011 Feb;46(2):548-61
All references(45)
Other
accession IDs
MGI:1276532

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory