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Ankrd1 Gene Detail
Summary
  • Symbol
    Ankrd1
  • Name
    ankyrin repeat domain 1 (cardiac muscle)
  • Synonyms
    Alrp, CARP, Crap, MARP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097717
    NCBI Gene: 107765
  • Gene Overview
    MyGene.info: ANKRD1
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:36111965-36119844 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 30.52 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    64 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1097717
protein coding gene Chr19:36111965-36119844 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025070
protein coding gene Chr19:34960452-34968895 (-)
A/J MGP_AJ_G0025046
protein coding gene Chr19:33294481-33302399 (-)
AKR/J MGP_AKRJ_G0025014
protein coding gene Chr19:34411565-34419480 (-)
BALB/cJ MGP_BALBcJ_G0025044
protein coding gene Chr19:33383179-33390949 (-)
C3H/HeJ MGP_C3HHeJ_G0024803
protein coding gene Chr19:34479453-34488303 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025485
protein coding gene Chr19:35979700-35989179 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022903
protein coding gene Chr19:32671645-32680391 (-)
CAST/EiJ MGP_CASTEiJ_G0024270
protein coding gene Chr19:34263283-34271037 (-)
CBA/J MGP_CBAJ_G0024780
protein coding gene Chr19:37687453-37696904 (-)
DBA/2J MGP_DBA2J_G0024912
protein coding gene Chr19:33161907-33169415 (-)
FVB/NJ MGP_FVBNJ_G0024873
protein coding gene Chr19:32968927-32976752 (-)
LP/J MGP_LPJ_G0024998
protein coding gene Chr19:35054893-35064939 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024904
protein coding gene Chr19:37519201-37527449 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025543
protein coding gene Chr19:34500226-34507974 (-)
PWK/PhJ MGP_PWKPhJ_G0024022
protein coding gene Chr19:32973370-32981424 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023822
protein coding gene Chr19:33337156-33345660 (-)
WSB/EiJ MGP_WSBEiJ_G0024337
protein coding gene Chr19:34591613-34600586 (-)



Homology
more
  • Human Ortholog
    ANKRD1, ankyrin repeat domain 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ANKRD1, ankyrin repeat domain 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALRP, bA320F15.2, C-193, CARP, CVARP, MCARP
  • Links
    NCBI Gene ID: 27063
    neXtProt AC: NX_Q15327
    UniProt: Q15327

  • Chr Location
    10q23.31; chr10:90912100-90921275 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8289
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ANKRD1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 4 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are viable, fertile, and show no apparent cardiac phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107765 NCBI Gene Model | MGI Sequence Detail 7880 C57BL/6J ±  kb
    transcript NM_013468 RefSeq | MGI Sequence Detail 1765 C57BL/6  
    polypeptide Q9CR42 UniProt | EBI | MGI Sequence Detail 319 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      Genomic 2
      cDNA 52
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-39620, MGI:109621
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 25
      Gene Ontology 12
      Phenotypes 11
    • Earliest
      J:38866 Zou Y, et al., CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway. Development. 1997 Feb;124(4):793-804
    • Latest
      J:260112 Filipova D, et al., Distinct transcriptomic changes in E14.5 mouse skeletal muscle lacking RYR1 or Cav1.1 converge at E18.5. PLoS One. 2018;13(3):e0194428

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory