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Bhlhe40
Gene Detail
Symbol

Name
ID
Bhlhe40
basic helix-loop-helix family, member e40
MGI:1097714
Synonyms
Bhlhb2, C130042M06Rik, Clast5, CR8, cytokine response gene 8, DEC1, eip1 (E47 interaction protein 1), Sharp2, Stra13, Stra14
Feature Type
protein coding gene
Genetic Map
Chromosome 6
49.85 cM, cytoband E-F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:108660629-108666925 bp, + strand
From VEGA annotation of GRCm38

  6297 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2722  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Bhlhe40

Human
homologs
Human Homolog BHLHE40, basic helix-loop-helix family, member e40
NCBI Gene ID 8553
neXtProt AC  NX_O14503
Human Synonyms  BHLHB2, DEC1, HLHB2, SHARP-2, STRA13, Stra14
Human Chr (Location)  3p26; chr3:4979412-4985181 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in impaired immune function and hyperplasia of the lymphoid organs. Aging mutant animals exhibit autoimmune disease.
 
Interactions
Bhlhe40 interacts with 269 markers (Mir1b, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process circadian regulation of gene expression, entrainment of circadian clock, ...
Component cytoplasm, Golgi apparatus, ...
Function bHLH transcription factor binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (104)    Tissues (80)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 79
Northern blot 11
RT-PCR 14
cDNA source data(147)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(150) Genomic(1) cDNA(147) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035997 (Evidence)
Ensembl Gene ModelENSMUSG00000030103 (Evidence)
Entrez Gene20893 (Evidence)
UniGene2436
DFCITC1574409
DoTSDT.530152, DT.55143981
NIA Mouse Gene IndexU007250
Consensus CDS ProjectCCDS20400.1
International Mouse Knockout Project StatusBhlhe40
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035997 VEGA Gene Model | MGI Sequence Detail 6297 C57BL/6J ±  kb
transcript OTTMUST00000092370 VEGA | MGI Sequence Detail 3113 Not Applicable 
polypeptide OTTMUSP00000051032 VEGA | MGI Sequence Detail 411 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(7)
Polymorphisms
SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR003650 Orange
InterPro IPR018352 Orange subgroup
Protein Ontology PR:000004740 class E basic helix-loop-helix protein 40
References
(Earliest) J:28316 Bouillet P, et al., Efficient cloning of cDNAs of retinoic acid-responsive genes in P19 embryonal carcinoma cells and characterization of a novel mouse gene, Stra1 (mouse LERK-2/Eplg2). Dev Biol. 1995 Aug;170(2):420-33
(Latest) J:213154 Lin CC, et al., Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation. Nat Commun. 2014;5:3551
All references(70)
Other
accession IDs
MGI:2443526

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory