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Kng1 Gene Detail
Summary
  • Symbol
    Kng1
  • Name
    kininogen 1
  • Synonyms
    H-kininigen, L-kininogen
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097705
    NCBI Gene: 16644
  • Gene Overview
    MyGene.info: KNG1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:23058220-23082078 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 13.88 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    130 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1097705
protein coding gene Chr16:23057865-23082078 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022677
protein coding gene Chr16:20606275-20632317 (+)
A/J MGP_AJ_G0022639
protein coding gene Chr16:19601817-19657886 (+)
AKR/J MGP_AKRJ_G0022613
protein coding gene Chr16:20455588-20489272 (+)
BALB/cJ MGP_BALBcJ_G0022644
protein coding gene Chr16:19802126-19841078 (+)
C3H/HeJ MGP_C3HHeJ_G0022408
protein coding gene Chr16:20548109-20607706 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023093
protein coding gene Chr16:21076131-21118014 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020611
protein coding gene Chr16:20260293-20286114 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0022379
protein coding gene Chr16:21930765-21979774 (+)
DBA/2J MGP_DBA2J_G0022511
protein coding gene Chr16:19566841-19607793 (+)
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0023105
protein coding gene Chr16:20383022-20423210 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0021507
protein coding gene Chr16:20126393-20150010 (+)
WSB/EiJ MGP_WSBEiJ_G0021981
protein coding gene Chr16:20346086-20382708 (+)



Homology
more
  • Human Ortholog
    KNG1, kininogen 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KNG1, kininogen 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BDK, BK, HMWK, KNG
  • Links
    NCBI Gene ID: 3827
    neXtProt AC: NX_P01042
    UniProt: P01042

  • Chr Location
    3q27.3; chr3:186717309-186744410 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 88343
    1 human;2 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KNG1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are viable and grossly unaffected with normal tail vein bleeding times, despite loss of detectable plasma kininogen. However, homozygotes show a significantly longer time to carotid artery occlusion after RoseBengal and laser-induced arterial injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16644 NCBI Gene Model | MGI Sequence Detail 23859 C57BL/6J ±  kb
transcript NM_001102411 RefSeq | MGI Sequence Detail 2299 Not Specified  
polypeptide O08677 UniProt | EBI | MGI Sequence Detail 661 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR000010 Cystatin domain
    IPR002395 HMW kininogen
    IPR027358 Kininogen-type cystatin domain
    IPR018073 Proteinase inhibitor I25, cystatin, conserved site
Molecular
Reagents
less
  • All nucleic 205
    cDNA 205

    Microarray probesets 4
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:46848 Caubin J, et al., Isolation of genomic DNA fragments corresponding to genes modulated in vivo by a transcription factor. Nucleic Acids Res. 1994 Oct 11;22(20):4132-8
  • Latest
    J:262744 Shetty R, et al., Rudhira/BCAS3 is essential for mouse development and cardiovascular patterning. Sci Rep. 2018 Apr 4;8(1):5632

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory