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Kng1 Gene Detail
Summary
  • Symbol
    Kng1
  • Name
    kininogen 1
  • Synonyms
    H-kininigen, L-kininogen
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097705
    NCBI Gene: 16644
  • Gene Overview
    MyGene.info: KNG1
Location & Maps
more
  • Sequence Map
    Chr16:23057865-23082068 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24204 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 13.88 cM, cytoband B1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KNG1, kininogen 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KNG1, kininogen 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BDK, BK, KNG
  • Links
    NCBI Gene ID: 3827
    neXtProt AC: NX_P01042

  • Chr Location
    3q27; chr3:186717309-186744410 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 88343
    1 human;2 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 frog, western clawed
  • HCOP
    human homology predictions: KNG1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human KNG1 associations

Human Disease Mouse Models
       High Molecular Weight Kininogen Deficiency   OMIM: 228960
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    9
  • Targeted
    1
  • Incidental Mutations
Mice homozygous for a targeted null mutation are viable and grossly unaffected with normal tail vein bleeding times, despite loss of detectable plasma kininogen. However, homozygotes show a significantly longer time to carotid artery occlusion after RoseBengal and laser-induced arterial injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025899 VEGA Gene Model | MGI Sequence Detail 24204 C57BL/6J ±  kb
transcript OTTMUST00000063825 VEGA | MGI Sequence Detail 2255 Not Applicable  
polypeptide OTTMUSP00000031625 VEGA | MGI Sequence Detail 661 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    134 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR000010 Cystatin domain
    IPR002395 HMW kininogen
    IPR027358 Kininogen-type cystatin domain
    IPR018073 Proteinase inhibitor I25, cystatin, conserved site
Molecular
Reagents
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  • All nucleic 204
    cDNA 204

    Microarray probesets 4
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:46848 Caubin J, et al., Isolation of genomic DNA fragments corresponding to genes modulated in vivo by a transcription factor. Nucleic Acids Res. 1994 Oct 11;22(20):4132-8
  • Latest
    J:226441 Nickel KF, et al., The polyphosphate-factor XII pathway drives coagulation in prostate cancer-associated thrombosis. Blood. 2015 Sep 10;126(11):1379-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory