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Kng1
Gene Detail
Symbol

Name
ID
Kng1
kininogen 1
MGI:1097705
Synonyms
H-kininigen, L-kininogen
Feature Type
protein coding gene
Genetic Map
Chromosome 16
13.88 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:23057865-23082068 bp, + strand
From VEGA annotation of GRCm38

  24204 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88343  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: KNG1
Gene Tree: Kng1

Human
homologs
KNG1, kininogen 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3827
neXtProt AC: NX_P01042

Human Synonyms: BDK, BK, KNG

Human Chr (Location): 3q27; chr3:186717309-186744410 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human KNG1

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(9) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation are viable and grossly unaffected with normal tail vein bleeding times, despite loss of detectable plasma kininogen. However, homozygotes show a significantly longer time to carotid artery occlusion after Rose Bengal and laser-induced arterial injury.
 
Interactions
Kng1 interacts with 84 markers (Mir27a, Mir27b, Mir30a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process blood coagulation, hemostasis, ...
Component blood microparticle, cytosol, ...
Function cysteine-type endopeptidase inhibitor activity, peptidase inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(204)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase kng1    NEW 
Molecular
reagents
All nucleic(204) cDNA(204)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000025899 (Evidence)
Ensembl Gene Model ENSMUSG00000022875 (Evidence)
Entrez Gene 16644 (Evidence)
UniGene 2160
DoTS DT.91447226, DT.496624, DT.101243227
NIA Mouse Gene Index U016954
Consensus CDS Project CCDS28073.1, CCDS49803.1, CCDS49804.1
International Mouse Phenotyping Consortium Status Kng1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025899 VEGA Gene Model | MGI Sequence Detail 24204 C57BL/6J ±  kb
transcript OTTMUST00000063825 VEGA | MGI Sequence Detail 2255 Not Applicable 
polypeptide OTTMUSP00000031625 VEGA | MGI Sequence Detail 661 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(10) UniProt(3)
Polymorphisms
SNPs within 2kb(151 from dbSNP Build 137)    SNPs within 2kb including multiple locations(213)
Protein-related
information
ResourceIDDescription
InterPro IPR002395 HMW kininogen
InterPro IPR027358 Kininogen-type cystatin domain
InterPro IPR000010 Proteinase inhibitor I25, cystatin
InterPro IPR018073 Proteinase inhibitor I25, cystatin, conserved site
Protein Ontology PR:000009430 kininogen-1
References
(Earliest) J:46848 Caubin J, et al., Isolation of genomic DNA fragments corresponding to genes modulated in vivo by a transcription factor. Nucleic Acids Res. 1994 Oct 11;22(20):4132-8
(Latest) J:192923 Yokota Y, et al., Absence of LTB4/BLT1 axis facilitates generation of mouse GM-CSF-induced long-lasting antitumor immunologic memory by enhancing innate and adaptive immune systems. Blood. 2012 Oct 25;120(17):3444-54
All references(32)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory