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Opn1mw
Gene Detail
 Symbol
Name
ID
Opn1mw
opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan)
MGI:1097692
Synonyms Gcp, green long wavelength sensitive cone opsin, green LWS cone opsin, green LWS photopigment, Green opsin, Midwavelength sensitive opsin, M opsin, MWS opsin
Feature Type protein coding gene
Genetic Map
Chromosome X
37.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
ChrX:74127464-74150760 bp, + strand
From VEGA annotation of GRCm38

  23297 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68064  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: animal opsin
Gene Tree: Opn1mw

Human
homologs
Human Homolog OPN1LW, opsin 1 (cone pigments), long-wave-sensitive
NCBI Gene ID 5956
Human Synonyms  CBBM, CBP, COD5, RCP, ROP
Human Chr (Location)  Xq28; chrX:154144224-154159032 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human OPN1LW
Alleles
and
phenotypes
All alleles(2) : Targeted(2)
 
A knock-in allele encoding a derivative of the human red cone pigment results in hemizygous male and homozygous female mice with a ~45-nm red shift in retinal sensitivity; heterozygous females show significant changes in the chromatic sensitivities of retinal ganglion cells.
 
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process G-protein coupled receptor signaling pathway, phototransduction, ...
Component integral component of membrane, membrane, ...
Function G-protein coupled receptor activity, photoreceptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (38)    Tissues (10)    Images (16)
Theiler Stages: 15, 17, 19, 20, 21, 22, 28
Assay TypeResults
Immunohistochemistry 8
RNA in situ 4
Northern blot 4
RT-PCR 22
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(17) cDNA(15) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000017694 (Evidence)
Ensembl Gene ModelENSMUSG00000031394 (Evidence)
Entrez Gene14539 (Evidence)
UniGene284825
DFCITC1587907
DoTSDT.40162223, DT.94283180
NIA Mouse Gene IndexU019951
Consensus CDS ProjectCCDS30220.1
International Mouse Knockout Project StatusOpn1mw
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017694 VEGA Gene Model | MGI Sequence Detail 23297 C57BL/6J ±  kb
transcript OTTMUST00000043833 VEGA | MGI Sequence Detail 1233 Not Applicable 
polypeptide OTTMUSP00000019681 VEGA | MGI Sequence Detail 389 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(98 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001760 Opsin
InterPro IPR000378 Opsin red/green sensitive
InterPro IPR027430 Visual pigments (opsins) retinal binding site
Protein Ontology PR:000001224 medium-wave-sensitive opsin 1
References (Earliest) J:42249 Sun H, et al., Mechanisms of spectral tuning in the mouse green cone pigment. Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8860-5
(Latest) J:203516 Yamashita T, et al., Chloride-dependent spectral tuning mechanism of L-group cone visual pigments. Biochemistry. 2013 Feb 19;52(7):1192-7
All references(74)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory