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Opn1mw Gene Detail
Summary
  • Symbol
    Opn1mw
  • Name
    opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan)
  • Synonyms
    Gcp, green long wavelength sensitive cone opsin, green LWS cone opsin, green LWS photopigment, Green opsin, Midwavelength sensitive opsin, M opsin, MWS opsin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097692
    NCBI Gene: 14539
  • Gene Overview
    MyGene.info: OPN1LW
Location & Maps
more
  • Sequence Map
    ChrX:74127464-74150760 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23297 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 37.76 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    OPN1LW, opsin 1 (cone pigments), long-wave-sensitive
  • Vertebrate Orthologs
    10
  • Human Ortholog
    OPN1LW, opsin 1 (cone pigments), long-wave-sensitive
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CBBM, CBP, COD5, RCP, ROP
  • Links
    NCBI Gene ID: 5956

  • Chr Location
    Xq28; chrX:154144224-154159032 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human OPN1LW associations

Human Disease Mouse Models
       Blue Cone Monochromacy; BCM   OMIM: 303700
Colorblindness, Partial, Protan Series; CBP   OMIM: 303900
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Targeted
    2
A knock-in allele encoding a derivative of the human red cone pigment results in hemizygous male and homozygous female mice with a ~45-nm red shift in retinal sensitivity; heterozygous females show significant changes in the chromatic sensitivities of retinal ganglion cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017694 VEGA Gene Model | MGI Sequence Detail 23297 C57BL/6J ±  kb
transcript OTTMUST00000043833 VEGA | MGI Sequence Detail 1233 Not Applicable  
polypeptide OTTMUSP00000019681 VEGA | MGI Sequence Detail 389 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    96 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR001760 Opsin
    IPR000378 Opsin red/green sensitive
    IPR027430 Visual pigments (opsins) retinal binding site
Molecular
Reagents
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  • All nucleic 18
    cDNA 15
    Primer pair 3

    Microarray probesets 2
References
more
  • Summaries
    All 75
    Developmental Gene Expression 36
    Gene Ontology 11
    Phenotypes 9
  • Earliest
    J:42249 Sun H, et al., Mechanisms of spectral tuning in the mouse green cone pigment. Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8860-5
  • Latest
    J:230346 Omori Y, et al., Mef2d is essential for the maturation and integrity of retinal photoreceptor and bipolar cells. Genes Cells. 2015 May;20(5):408-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory