Opn1mw
Gene Detail

Symbol Name ID

Opn1mw opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan) MGI:1097692

Synonyms

Gcp, green long wavelength sensitive cone opsin, green LWS cone opsin, green LWS photopigment, Green opsin, Midwavelength sensitive opsin, M opsin, MWS opsin

Feature Type

protein coding gene

Genetic Map

Chromosome X

37.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

ChrX:74127464-74150760 bp, + strand From VEGA annotation of GRCm38   23297 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68064  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: animal opsin
Gene Tree: Opn1mw

Human homologs

Human Homolog		OPN1LW, opsin 1 (cone pigments), long-wave-sensitive
NCBI Gene ID		5956
neXtProt AC		NX_P04000
Human Synonyms		CBBM, CBP, COD5, RCP, ROP
Human Chr (Location)		Xq28; chrX:153409725-153424507 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human OPN1LW

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

A knock-in allele encoding a derivative of the human red cone pigment results in hemizygous male and homozygous female mice with a ~45-nm red shift in retinal sensitivity; heterozygous females show significant changes in the chromatic sensitivities of retinal ganglion cells.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	G-protein coupled receptor signaling pathway, phototransduction, ...
Component	integral to membrane, membrane, ...
Function	G-protein coupled receptor activity, photoreceptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (32 records)
Data Summary: Results (30)    Tissues (9)    Images (8)
Theiler Stages: 15, 17, 19, 20, 21, 22, 28

Assay Type	Results
RNA in situ	4
Northern blot	4
RT-PCR	22

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(15) Primer pair(2)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000017694 (Evidence)
Ensembl Gene Model	ENSMUSG00000031394 (Evidence)
Entrez Gene	14539 (Evidence)
UniGene	284825
DFCI	TC1587907
DoTS	DT.40162223, DT.94283180
NIA Mouse Gene Index	U019951
Consensus CDS Project	CCDS30220.1
International Mouse Knockout Project Status	Opn1mw

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017694	VEGA Gene Model | MGI Sequence Detail	23297	C57BL/6J
transcript	OTTMUST00000043833	VEGA | MGI Sequence Detail	1233	Not Applicable
polypeptide	OTTMUSP00000019681	VEGA | MGI Sequence Detail	389	Not Applicable

All sequences(42) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(84 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR001760	Opsin
InterPro	IPR000378	Opsin, red/green sensitive
Protein Ontology	PR:000001224	medium-wave-sensitive opsin 1

References

(Earliest) J:42249 Sun H, et al., Mechanisms of spectral tuning in the mouse green cone pigment. Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8860-5
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(68)