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Ackr1
Gene Detail
Symbol

Name
ID
Ackr1
atypical chemokine receptor 1 (Duffy blood group)
MGI:1097689
Synonyms
CCBP1, CD234, Darc, Dfy, ESTM35, FY
Feature Type
protein coding gene
Genetic Map
Chromosome 1
80.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr1:173331886-173333750 bp, - strand
From VEGA annotation of GRCm38

  1865 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48067  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: ACKR1
Protein SuperFamily: Duffy antigen chemokine receptor
Gene Tree: Ackr1

Human
homologs
ACKR1, atypical chemokine receptor 1 (Duffy blood group)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2532
neXtProt AC: NX_Q16570

Human Synonyms: CCBP1, CD234, DARC, Dfy, FY, GPD, GpFy, WBCQ1

Human Chr (Location): 1q21-q22; chr1:159204013-159206500 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ACKR1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants are healthy, but erythrocytes lack CXC and CC chemokine-binding activity, such that when challenged with LPS result in increased inflammatory infiltrates in lung and liver.
 
Interactions
Ackr1 interacts with 12 markers (Mir142, Mir151, Mir214, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process chemokine-mediated signaling pathway, G-protein coupled receptor signaling pathway, ...
Component endosome, integral component of membrane, ...
Function C-C chemokine binding, chemokine binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (214)    Tissues (109)    Images (59)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 26
RNA in situ 166
Northern blot 15
RT-PCR 7
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) Genomic(21) cDNA(23) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000050197 (Evidence)
Ensembl Gene Model ENSMUSG00000037872 (Evidence)
Entrez Gene 13349 (Evidence)
UniGene 6393
DFCI TC1582527
DoTS DT.94226461, DT.527212, DT.101192949
NIA Mouse Gene Index U022083
Consensus CDS Project CCDS35789.1
International Mouse Phenotyping Consortium Status Ackr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050197 VEGA Gene Model | MGI Sequence Detail 1865 C57BL/6J ±  kb
transcript OTTMUST00000127569 VEGA | MGI Sequence Detail 1153 Not Applicable 
polypeptide OTTMUSP00000068791 VEGA | MGI Sequence Detail 334 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(79 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005384 Duffy antigen/chemokine receptor
Protein Ontology PR:000001132 duffy antigen/chemokine receptor
References
(Earliest) J:38315 Luo H, et al., Cloning, characterization, and mapping of a murine promiscuous chemokine receptor gene: homolog of the human Duffy gene [letter]. Genome Res. 1997 Sep;7(9):932-41
(Latest) J:212860 Wantha S, et al., Neutrophil-derived cathelicidin promotes adhesion of classical monocytes. Circ Res. 2013 Mar 1;112(5):792-801
All references(58)
Other
accession IDs
MGI:1334436

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory