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Ackr1 Gene Detail
Summary
  • Symbol
    Ackr1
  • Name
    atypical chemokine receptor 1 (Duffy blood group)
  • Synonyms
    CCBP1, CD234, Darc, Dfy, ESTM35, FY
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097689
    NCBI Gene: 13349
  • Gene Overview
    MyGene.info: ACKR1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:173331886-173333750 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1865 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 80.33 cM
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    ACKR1, atypical chemokine receptor 1 (Duffy blood group)
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ACKR1, atypical chemokine receptor 1 (Duffy blood group)
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CCBP1, CD234, DARC, DARC/ACKR1, Dfy, FY, GPD, GpFy, WBCQ1
  • Links
    NCBI Gene ID: 2532
    neXtProt AC: NX_Q16570
    UniProt: Q16570

  • Chr Location
    1q23.2; chr1:159204013-159206500 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ACKR1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants are healthy, but erythrocytes lack CXC and CC chemokine-binding activity, such that when challenged with LPS result in increased inflammatory infiltrates in lung and liver.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000050197 VEGA Gene Model | MGI Sequence Detail 1865 C57BL/6J ±  kb
    transcript OTTMUST00000127569 VEGA | MGI Sequence Detail 1153 Not Applicable  
    polypeptide OTTMUSP00000068791 VEGA | MGI Sequence Detail 334 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      77 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR005384 Duffy antigen/chemokine receptor
    Molecular
    Reagents
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    • All nucleic 49
      Genomic 21
      cDNA 24
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1334436
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 7
      Gene Ontology 6
      Phenotypes 22
    • Earliest
      J:38315 Luo H, et al., Cloning, characterization, and mapping of a murine promiscuous chemokine receptor gene: homolog of the human Duffy gene [letter]. Genome Res. 1997 Sep;7(9):932-41
    • Latest
      J:257958 Duchene J, et al., Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis. Nat Immunol. 2017 Jul;18(7):753-761

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory