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Ackr1
Gene Detail
 Symbol
Name
ID
Ackr1
atypical chemokine receptor 1 (Duffy blood group)
MGI:1097689
Synonyms CCBP1, CD234, Darc, Dfy, ESTM35, FY
Feature Type protein coding gene
Genetic Map
Chromosome 1
80.33 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr1:173331886-173333503 bp, - strand
From NCBI annotation of GRCm38

  1618 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48067  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: Duffy antigen chemokine receptor
Gene Tree: Ackr1

Human
homologs
Human Homolog ACKR1, atypical chemokine receptor 1 (Duffy blood group)
NCBI Gene ID 2532
neXtProt AC  NX_Q16570
Human Synonyms  CCBP1, CD234, DARC, Dfy, FY, GPD, GpFy, WBCQ1
Human Chr (Location)  1q21-q22; chr1:159204013-159206500 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ACKR1
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants are healthy, but erythrocytes lack CXC and CC chemokine-binding activity, such that when challenged with LPS result in increased inflammatory infiltrates in lung and liver.
 
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process chemokine-mediated signaling pathway, G-protein coupled receptor signaling pathway, ...
Component endosome, integral component of membrane, ...
Function C-C chemokine binding, chemokine binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (214)    Tissues (107)    Images (59)
Theiler Stages: 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 26
RNA in situ 166
Northern blot 15
RT-PCR 7
cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(48) Genomic(21) cDNA(23) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000037872 (Evidence)
Entrez Gene13349 (Evidence)
UniGene6393
DFCITC1582527
DoTSDT.101192949, DT.527212, DT.94226461
NIA Mouse Gene IndexU022083
Consensus CDS ProjectCCDS35789.1
International Mouse Knockout Project StatusAckr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13349 NCBI Gene Model | MGI Sequence Detail 1618 C57BL/6J ±  kb
transcript NM_010045 RefSeq | MGI Sequence Detail 1158 C57BL/6 
polypeptide Q9QUI6 UniProt | EBI | MGI Sequence Detail 334 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(3)
Polymorphisms RFLP(2) : SNPs within 2kb(78 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005384 Duffy antigen/chemokine receptor
Protein Ontology PR:000001132 duffy antigen/chemokine receptor
Graphical View of Protein Domain Structure
References (Earliest) J:38315 Luo H, et al., Cloning, characterization, and mapping of a murine promiscuous chemokine receptor gene: homolog of the human Duffy gene [letter]. Genome Res. 1997 Sep;7(9):932-41
(Latest) J:209105 Rundle CH, et al., Duffy antigen receptor for chemokines regulates post-fracture inflammation. PLoS One. 2013;8(10):e77362
All references(57)
Other
accession IDs
MGI:1334436

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory