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H3f3a Gene Detail
Summary
  • Symbol
    H3f3a
  • Name
    H3 histone, family 3A
  • Synonyms
    H3.3A
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097686
    NCBI Gene: 15078
  • Gene Overview
    MyGene.info: H3F3A
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:180802560-180813605 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 84.46 cM, cytoband D2.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    56 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1097686
protein coding gene Chr1:180800832-180813943 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016874
protein coding gene Chr1:187260176-187275877 (-)
A/J MGP_AJ_G0016853
protein coding gene Chr1:179683855-179702144 (-)
AKR/J MGP_AKRJ_G0016819
protein coding gene Chr1:185024579-185040759 (-)
BALB/cJ MGP_BALBcJ_G0016811
protein coding gene Chr1:180309955-180324292 (-)
C3H/HeJ MGP_C3HHeJ_G0016636
protein coding gene Chr1:185795739-185810240 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017274
protein coding gene Chr1:193292963-193298088 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014982
protein coding gene Chr1:170667960-170680805 (-)
CAST/EiJ MGP_CASTEiJ_G0016217
protein coding gene Chr1:185143702-185159821 (-)
CBA/J MGP_CBAJ_G0016610
protein coding gene Chr1:200468560-200483951 (-)
DBA/2J MGP_DBA2J_G0016716
protein coding gene Chr1:178519654-178532444 (-)
FVB/NJ MGP_FVBNJ_G0016712
protein coding gene Chr1:176616991-176629725 (-)
LP/J MGP_LPJ_G0016790
protein coding gene Chr1:188518849-188536264 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016743
protein coding gene Chr1:207648358-207661034 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017311
protein coding gene Chr1:184808925-184823154 (-)
PWK/PhJ MGP_PWKPhJ_G0016005
protein coding gene Chr1:177634167-177647075 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015781
protein coding gene Chr1:183744359-183756903 (-)
WSB/EiJ MGP_WSBEiJ_G0016280
protein coding gene Chr1:184999545-185012240 (-)



Homology
more
  • Human Ortholog
    H3F3A, H3 histone family member 3A
  • Vertebrate Orthologs
    17
  • Human Ortholog
    H3F3A, H3 histone family member 3A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    H3.3A, H3F3
  • Links
    NCBI Gene ID: 3020
    neXtProt AC: NX_P84243
    UniProt: P84243

  • Chr Location
    1q42.12; chr1:226062707-226072002 (+)  GRCh38.p7

  • Human Ortholog
    H3F3B, H3 histone family member 3B
    Orthology source: HomoloGene
  • Synonyms
    H3.3B
  • Links
    NCBI Gene ID: 3021
    neXtProt AC: NX_P84243
    UniProt: P84243

  • Chr Location
    17q25.1; chr17:75776434-75779935 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants for a hypomorphic gene trap allele display partial neonatal lethality, reduced fertility, growth abnormalities and neuromuscular defects. Mice homozygous for a reporter allele exhibit reduced body size and male fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15078 NCBI Gene Model | MGI Sequence Detail 11046 C57BL/6J ±  kb
    transcript NM_008210 RefSeq | MGI Sequence Detail 1086 C57BL/6  
    polypeptide NP_032236 RefSeq | MGI Sequence Detail 136 C57BL/6  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 30
      Primer pair 2
      Other 1

      Microarray probesets 9
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 16
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:42392 Hraba-Renevey S, et al., Expression of a mouse replacement histone H3.3 gene with a highly conserved 3' noncoding region during SV40- and polyoma-induced Go to S-phase transition. Nucleic Acids Res. 1989 Apr 11;17(7):2449-61
    • Latest
      J:256001 Jung EM, et al., Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior. Nat Neurosci. 2017 Dec;20(12):1694-1707

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory