About   Help   FAQ
Upp1 Gene Detail
Summary
  • Symbol
    Upp1
  • Name
    uridine phosphorylase 1
  • Synonyms
    UdRPase, Up, UPase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097668
    NCBI Gene: 22271
  • Gene Overview
    MyGene.info: UPP1
Location & Maps
more
  • Sequence Map
    Chr11:9118103-9136170 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18068 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 6.13 cM, cytoband A1-2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    UPP1, uridine phosphorylase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UPP1, uridine phosphorylase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    UDRPASE, UP, UPASE, UPP
  • Links
    NCBI Gene ID: 7378
    neXtProt AC: NX_Q16831

  • Chr Location
    7p12.3; chr7:48088603-48108733 (+)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted disruption have increased uridine concentration in tissues, urine and blood, along with disorders of various nucleotide metabolisms and decreased sensitivity to pentobarbital and 5-fluorouracil.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005150 VEGA Gene Model | MGI Sequence Detail 18068 C57BL/6J ±  kb
transcript OTTMUST00000011512 VEGA | MGI Sequence Detail 1277 Not Applicable  
polypeptide OTTMUSP00000005353 VEGA | MGI Sequence Detail 311 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    95 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 39
    Genomic 1
    cDNA 36
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2144130
References
more
  • Summaries
    All 45
    Developmental Gene Expression 4
    Diseases 3
    Gene Ontology 5
    Phenotypes 18
  • Earliest
    J:25521 Watanabe SI, et al., Purification, cloning, and expression of murine uridine phosphorylase. J Biol Chem. 1995 MAY 19;270(20):12191-12196
  • Latest
    J:231472 Cao Z, et al., Uridine homeostatic disorder leads to DNA damage and tumorigenesis. Cancer Lett. 2016 Mar 28;372(2):219-25

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory