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Tcl1 Gene Detail
Summary
  • Symbol
    Tcl1
  • Name
    T cell lymphoma breakpoint 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097166
    NCBI Gene: 21432
  • Gene Overview
    MyGene.info: TCL1A
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:105216750-105222793 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6044 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 55.28 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    TCL1A, T cell leukemia/lymphoma 1A
  • Vertebrate Orthologs
    6
  • Human Ortholog
    TCL1A, T cell leukemia/lymphoma 1A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TCL1
  • Links
    NCBI Gene ID: 8115
    neXtProt AC: NX_P56279
    UniProt: P56279

  • Chr Location
    14q32.13; chr14:95694160-95714196 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    35 phenotypes from multigenic genotypes
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display a maternal fertility defect that leads to a progressive reduction in litter size and a shortened reproductive lifespan. Reduced female fertility is caused by impaired blastomere proliferation in the early preimplantation embryo.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000042098 VEGA Gene Model | MGI Sequence Detail 6044 C57BL/6J ±  kb
    transcript OTTMUST00000110420 VEGA | MGI Sequence Detail 1299 Not Applicable  
    polypeptide OTTMUSP00000061588 VEGA | MGI Sequence Detail 193 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      74 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 97
      Genomic 2
      cDNA 92
      Primer pair 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 6
      Diseases 4
      Gene Ontology 5
      Phenotypes 71
    • Earliest
      J:42464 Narducci MG, et al., The murine Tcl1 oncogene: embryonic and lymphoid cell expression. Oncogene. 1997 Aug 18;15(8):919-26
    • Latest
      J:260709 Ozer HG, et al., BRD4 Profiling Identifies Critical Chronic Lymphocytic Leukemia Oncogenic Circuits and Reveals Sensitivity to PLX51107, a Novel Structurally Distinct BET Inhibitor. Cancer Discov. 2018 Apr;8(4):458-477

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory