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Tcl1
Gene Detail
Symbol

Name
ID
Tcl1
T cell lymphoma breakpoint 1
MGI:1097166
Feature Type
protein coding gene
Genetic Map
Chromosome 12
55.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr12:105216750-105222793 bp, - strand
From VEGA annotation of GRCm38

  6044 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7565  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

HCOP human homology predictions: TCL1A
Gene Tree: Tcl1

Human
homologs
TCL1A, T-cell leukemia/lymphoma 1A
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8115
neXtProt AC: NX_P56279

Human Synonyms: TCL1

Human Chr (Location): 14q32.1; chr14:95709967-95714196 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(2) Transgenic(3)
 
Mice homozygous for a knock-out allele display a maternal fertility defect that leads to a progressive reduction in litter size and a shortened reproductive lifespan. Reduced female fertility is caused by impaired blastomere proliferation in the early preimplantation embryo.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Tcl1 interacts with 113 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process stem cell maintenance
Component cell cortex, cytoplasm, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (86)    Tissues (25)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 7
RT-PCR 79
cDNA source data(92)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(97) Genomic(2) cDNA(92) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000042098 (Evidence)
Ensembl Gene Model ENSMUSG00000041359 (Evidence)
Entrez Gene 21432 (Evidence)
UniGene 18154
DFCI TC1693864, TC1642378, TC1575202
DoTS DT.110919329, DT.110919285, DT.535628, DT.99847502
NIA Mouse Gene Index U034315
PDB 1JNP
Consensus CDS Project CCDS36549.1, CCDS70418.1
International Mouse Phenotyping Consortium Status Tcl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042098 VEGA Gene Model | MGI Sequence Detail 6044 C57BL/6J ±  kb
transcript OTTMUST00000110420 VEGA | MGI Sequence Detail 1299 Not Applicable 
polypeptide OTTMUSP00000061588 VEGA | MGI Sequence Detail 193 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(7) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(74 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004832 TCL1/MTCP1
Protein Ontology PR:000016193 T-cell leukemia/lymphoma protein 1A
References
(Earliest) J:42464 Narducci MG, et al., The murine Tcl1 oncogene: embryonic and lymphoid cell expression. Oncogene. 1997 Aug 18;15(8):919-26
(Latest) J:205904 Miyazaki T, et al., Functional analysis of Tcl1 using Tcl1-deficient mouse embryonic stem cells. PLoS One. 2013;8(8):e71645
All references(40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory