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Pold2 Gene Detail
Summary
  • Symbol
    Pold2
  • Name
    polymerase (DNA directed), delta 2, regulatory subunit
  • Synonyms
    50kDa, p50, po1D2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097163
    NCBI Gene: 18972
  • Gene Overview
    MyGene.info: POLD2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:5872180-5878256 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 3.88 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    36 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1097163
protein coding gene Chr11:5872180-5878292 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018010
protein coding gene Chr11:2957963-2964066 (-)
A/J MGP_AJ_G0017983
protein coding gene Chr11:2840155-2846248 (-)
AKR/J MGP_AKRJ_G0017947
protein coding gene Chr11:2991507-2997618 (-)
BALB/cJ MGP_BALBcJ_G0017951
protein coding gene Chr11:2834687-2840792 (-)
C3H/HeJ MGP_C3HHeJ_G0017764
protein coding gene Chr11:2865169-2871273 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018403
protein coding gene Chr11:3038145-3044255 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016061
protein coding gene Chr11:2739925-2745975 (-)
CAST/EiJ MGP_CASTEiJ_G0017326
protein coding gene Chr11:2832651-2838761 (-)
CBA/J MGP_CBAJ_G0017739
protein coding gene Chr11:3402450-3408558 (-)
DBA/2J MGP_DBA2J_G0017849
protein coding gene Chr11:2748464-2754574 (-)
FVB/NJ MGP_FVBNJ_G0017841
protein coding gene Chr11:2778003-2784092 (-)
LP/J MGP_LPJ_G0017920
protein coding gene Chr11:3036775-3042866 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017867
protein coding gene Chr11:3004562-3010673 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018443
protein coding gene Chr11:2996285-3002374 (-)
PWK/PhJ MGP_PWKPhJ_G0017106
protein coding gene Chr11:2772610-2778921 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016903
protein coding gene Chr11:2961035-2969666 (-)
WSB/EiJ MGP_WSBEiJ_G0017380
protein coding gene Chr11:2837395-2843498 (-)



Homology
more
  • Human Ortholog
    POLD2, DNA polymerase delta 2, accessory subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    POLD2, DNA polymerase delta 2, accessory subunit
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 5425
    neXtProt AC: NX_P49005
    UniProt: P49005

  • Chr Location
    7p13; chr7:44114680-44123668 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality between implantation and somite formation and failure of blastocysts to hatch from the zona pellucida with increased cell death during outgrowth culture.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18972 NCBI Gene Model | MGI Sequence Detail 6077 C57BL/6J ±  kb
    transcript NM_008894 RefSeq | MGI Sequence Detail 1634 C57BL/6  
    polypeptide O35654 UniProt | EBI | MGI Sequence Detail 469 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000012964 DNA polymerase delta subunit 2
    • InterPro Domains
      IPR007185 DNA polymerase alpha/delta/epsilon, subunit B
      IPR024826 DNA polymerase delta/II small subunit family
      IPR041863 DNA polymerase delta subunit 2, C-terminal domain
      IPR040663 DNA polymerase delta subunit, OB-fold domain
    Molecular
    Reagents
    less
    • All nucleic 96
      cDNA 95
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:42588 Hindges R, et al., Cloning, chromosomal localization, and interspecies interaction of mouse DNA polymerase delta small subunit (PolD2). Genomics. 1997 Aug 15;44(1):45-51
    • Latest
      J:261973 Bellelli R, et al., Polepsilon Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis. Mol Cell. 2018 May 17;70(4):707-721.e7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    04/06/2021
    MGI 6.16
    The Jackson Laboratory