Bak1
Gene Detail

Symbol Name ID

Bak1 BCL2-antagonist/killer 1 MGI:1097161

Synonyms

Bak, N-Bak

Feature Type

protein coding gene

Genetic Map

Chromosome 17

13.65 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr17:27019810-27029009 bp, - strand From VEGA annotation of GRCm38   9200 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:917  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: Bcl2 homologous antagonist/killer
Gene Tree: Bak1

Human homologs

Human Homolog		BAK1, BCL2-antagonist/killer 1
NCBI Gene ID		578
neXtProt AC		NX_Q16611
Human Synonyms		BAK, BAK-LIKE, BCL2L7, CDN1
Human Chr (Location)		6p21.3; chr6:33540323-33548070 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(14) : Targeted(1) Gene trapped(13)
 

Homozygous mutation of this gene does not result in a phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (77 annotations)

Process	activation of cysteine-type endopeptidase activity, activation of cysteine-type endopeptidase activity involved in apoptotic process, ...
Component	cytosol, endoplasmic reticulum, ...
Function	BH domain binding, chaperone binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (82)    Tissues (57)    Images (5)
Theiler Stages: 18, 20, 21, 23, 25, 26, 28

Assay Type	Results
Western blot	3
RT-PCR	47
RNase protection	32

cDNA source data(54)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(58) Genomic(1) cDNA(54) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000030987 (Evidence)
Ensembl Gene Model	ENSMUSG00000057789 (Evidence)
Entrez Gene	12018 (Evidence)
UniGene	2443
DFCI	TC1578678, TC1590995
DoTS	DT.101725514, DT.492638
NIA Mouse Gene Index	U037587
PDB	2VOH
Consensus CDS Project	CCDS28558.1
International Mouse Knockout Project Status	Bak1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030987	VEGA Gene Model | MGI Sequence Detail	9200	C57BL/6J
transcript	OTTMUST00000076752	VEGA | MGI Sequence Detail	2387	Not Applicable
polypeptide	OTTMUSP00000040454	VEGA | MGI Sequence Detail	209	Not Applicable

All sequences(42) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(27 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026308	Apoptosis regulator BAK
InterPro	IPR020717	Apoptosis regulator, Bcl-2, BH1 motif, conserved site
InterPro	IPR020726	Apoptosis regulator, Bcl-2, BH2 motif, conserved site
InterPro	IPR020728	Apoptosis regulator, Bcl-2, BH3 motif, conserved site
InterPro	IPR002475	Bcl2-like
InterPro	IPR026298	Blc2 family
Protein Ontology	PR:000002185	Bcl2 homologous antagonist/killer

References

(Earliest) J:43660 Chittenden T, et al., A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. EMBO J. 1995 Nov 15;14(22):5589-96
(Latest) J:194535 Warr MR, et al., FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature. 2013 Feb 21;494(7437):323-7
All references(159)