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Bak1
Gene Detail
Symbol

Name
ID
Bak1
BCL2-antagonist/killer 1
MGI:1097161
Synonyms
Bak, N-Bak
Feature Type
protein coding gene
Genetic Map
Chromosome 17
13.65 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:27019810-27029009 bp, - strand
From VEGA annotation of GRCm38

  9200 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:917  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: BAK1
Protein SuperFamily: Bcl2 homologous antagonist/killer
Gene Tree: Bak1

Human
homologs
BAK1, BCL2-antagonist/killer 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 578
neXtProt AC: NX_Q16611

Human Synonyms: BAK, BAK-LIKE, BCL2L7, CDN1

Human Chr (Location): 6p21.3; chr6:33572546-33580299 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(13) Radiation induced(2) Targeted(1)
Genomic Mutations involving Bak1 (2)
Incidental mutations (data from Mutagenetix )
 
Homozygous mutation of this gene does not result in a phenotype.
 
Interactions
Bak1 interacts with 171 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (13 records)
Data Summary: Results (82)    Tissues (58)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 3
RT-PCR 47
RNase protection 32
cDNA source data(55)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(59) Genomic(1) cDNA(55) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000030987 (Evidence)
Ensembl Gene Model ENSMUSG00000057789 (Evidence)
Entrez Gene 12018 (Evidence)
UniGene 2443
DFCI TC1578678, TC1590995
DoTS DT.101725514, DT.492638
NIA Mouse Gene Index U037587
PDB 2VOH
Consensus CDS Project CCDS28558.1
International Mouse Phenotyping Consortium Status Bak1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030987 VEGA Gene Model | MGI Sequence Detail 9200 C57BL/6J ±  kb
transcript OTTMUST00000076752 VEGA | MGI Sequence Detail 2387 Not Applicable 
polypeptide OTTMUSP00000040454 VEGA | MGI Sequence Detail 209 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(3) UniProt(3)
Polymorphisms
SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026308 Apoptosis regulator BAK
InterPro IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved site
InterPro IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved site
InterPro IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved site
InterPro IPR002475 Bcl2-like
InterPro IPR026298 Blc2 family
Protein Ontology PR:000002185 bcl-2 homologous antagonist/killer
References
(Earliest) J:43660 Chittenden T, et al., A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. EMBO J. 1995 Nov 15;14(22):5589-96
(Latest) J:220019 Schwarzer C, et al., Paraoxonase 2 Serves a Proapopotic Function in Mouse and Human Cells in Response to the Pseudomonas aeruginosa Quorum-sensing Molecule N-(3-Oxododecanoyl)-homoserine Lactone. J Biol Chem. 2015 Mar 13;290(11):7247-58
All references(190)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory