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Bak1
Gene Detail
 Symbol
Name
ID
Bak1
BCL2-antagonist/killer 1
MGI:1097161
Synonyms Bak, N-Bak
Feature Type protein coding gene
Genetic Map
Chromosome 17
13.65 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:27019810-27029009 bp, - strand
From VEGA annotation of GRCm38

  9200 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:917  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: Bcl2 homologous antagonist/killer
Gene Tree: Bak1

Human
homologs
Human Homolog BAK1, BCL2-antagonist/killer 1
NCBI Gene ID 578
neXtProt AC  NX_Q16611
Human Synonyms  BAK, BAK-LIKE, BCL2L7, CDN1
Human Chr (Location)  6p21.3; chr6:33572546-33580296 (-)  GRCh38
Alleles
and
phenotypes
All alleles(14) : Targeted(1) Gene trapped(13)
 
Homozygous mutation of this gene does not result in a phenotype.
 
Gene Ontology
(GO)
classifications
All GO classifications: (85 annotations)
Process activation of cysteine-type endopeptidase activity, activation of cysteine-type endopeptidase activity involved in apoptotic process, ...
Component cytosol, endoplasmic reticulum, ...
Function BH domain binding, chaperone binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (82)    Tissues (57)    Images (5)
Theiler Stages: 18, 20, 21, 23, 25, 26, 28
Assay TypeResults
Western blot 3
RT-PCR 47
RNase protection 32
cDNA source data(55)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(59) Genomic(1) cDNA(55) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000030987 (Evidence)
Ensembl Gene ModelENSMUSG00000057789 (Evidence)
Entrez Gene12018 (Evidence)
UniGene2443
DFCITC1590995, TC1578678
DoTSDT.101725514, DT.492638
NIA Mouse Gene IndexU037587
PDB2VOH
Consensus CDS ProjectCCDS28558.1
International Mouse Knockout Project StatusBak1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030987 VEGA Gene Model | MGI Sequence Detail 9200 C57BL/6J ±  kb
transcript OTTMUST00000076752 VEGA | MGI Sequence Detail 2387 Not Applicable 
polypeptide OTTMUSP00000040454 VEGA | MGI Sequence Detail 209 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(5) UniProt(5)
Polymorphisms SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026308 Apoptosis regulator BAK
InterPro IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved site
InterPro IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved site
InterPro IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved site
InterPro IPR002475 Bcl2-like
InterPro IPR026298 Blc2 family
Protein Ontology PR:000002185 Bcl2 homologous antagonist/killer
References (Earliest) J:43660 Chittenden T, et al., A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. EMBO J. 1995 Nov 15;14(22):5589-96
(Latest) J:205616 Imao T, et al., Apaf-1- and Caspase-8-independent apoptosis. Cell Death Differ. 2013 Feb;20(2):343-52
All references(176)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory