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P2rx3
Gene Detail
Symbol

Name
ID
P2rx3
purinergic receptor P2X, ligand-gated ion channel, 3
MGI:1097160
Synonyms
4930513E20Rik, MGC:28163, P2X3
Feature Type
protein coding gene
Genetic Map
Chromosome 2
49.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:84998583-85037462 bp, - strand
From VEGA annotation of GRCm38

  38880 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1922  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: P2RX3
Protein SuperFamily: P2X purinoceptor
Gene Tree: P2rx3

Human
homologs
P2RX3, purinergic receptor P2X, ligand gated ion channel, 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5024
neXtProt AC: NX_P56373

Human Synonyms: P2X3

Human Chr (Location): 11q12; chr11:57335946-57372399 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Genomic Mutations involving P2rx3 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show normal ventilatory responses to hypoxia. Mice homozygous for a reporter allele show loss of rapidly desensitizing ATP-gated cation currents in dorsal root ganglion neurons, reduced formalin-evoked pain behavior, and enhanced thermal hyperalgesia.
 
Interactions
P2rx3 interacts with 76 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (15 records)
Data Summary: Results (51)    Tissues (10)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 48
RT-PCR 3
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) Genomic(3) cDNA(7) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000013455 (Evidence)
Ensembl Gene Model ENSMUSG00000027071 (Evidence)
Entrez Gene 228139 (Evidence)
DFCI TC1587208, TC1657990, TC1608517, TC1594214
DoTS DT.40143995, DT.55154602
NIA Mouse Gene Index U341311, U022821, U022822
Consensus CDS Project CCDS16200.1
International Mouse Phenotyping Consortium Status P2rx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013455 VEGA Gene Model | MGI Sequence Detail 38880 C57BL/6J ±  kb
transcript OTTMUST00000032530 VEGA | MGI Sequence Detail 1812 Not Applicable 
polypeptide OTTMUSP00000014450 VEGA | MGI Sequence Detail 397 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(10) UniProt(4)
Polymorphisms
SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003046 P2X3 purinoceptor
InterPro IPR001429 P2X purinoreceptor
InterPro IPR027309 P2X purinoreceptor extracellular domain
Protein Ontology PR:000012190 P2X purinoceptor 3
References
(Earliest) J:42467 Souslova V, et al., Structure and chromosomal mapping of the mouse P2X3 gene. Gene. 1997 Aug 11;195(1):101-11
(Latest) J:217303 Koudelka J, et al., Genetic dissection of TrkB activated signalling pathways required for specific aspects of the taste system. Neural Dev. 2014;9:21
All references(65)
Other
accession IDs
MGI:1926054

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory