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P2rx3 Gene Detail
Summary
  • Symbol
    P2rx3
  • Name
    purinergic receptor P2X, ligand-gated ion channel, 3
  • Synonyms
    4930513E20Rik, MGC:28163, P2X3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097160
    NCBI Gene: 228139
  • Gene Overview
    MyGene.info: P2RX3
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:84998583-85037462 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 49.45 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    138 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1097160
protein coding gene Chr2:84996549-85037462 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025919
protein coding gene Chr2:85704725-85746543 (-)
A/J MGP_AJ_G0025893
protein coding gene Chr2:82383266-82422325 (-)
AKR/J MGP_AKRJ_G0025863
protein coding gene Chr2:84515971-84556061 (-)
BALB/cJ MGP_BALBcJ_G0025890
protein coding gene Chr2:82513917-82552953 (-)
C3H/HeJ MGP_C3HHeJ_G0025649
protein coding gene Chr2:84745302-84783723 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026336
protein coding gene Chr2:88360662-88400530 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023738
protein coding gene Chr2:79211442-79251448 (-)
CAST/EiJ MGP_CASTEiJ_G0025110
protein coding gene Chr2:85297375-85338206 (-)
CBA/J MGP_CBAJ_G0025630
protein coding gene Chr2:91510452-91555262 (-)
DBA/2J MGP_DBA2J_G0025761
protein coding gene Chr2:81920598-81959351 (-)
FVB/NJ MGP_FVBNJ_G0025724
protein coding gene Chr2:81178122-81216598 (-)
LP/J MGP_LPJ_G0025849
protein coding gene Chr2:85496509-85536962 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025754
protein coding gene Chr2:93831323-93871927 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026392
protein coding gene Chr2:84762154-84801899 (-)
PWK/PhJ MGP_PWKPhJ_G0024854
protein coding gene Chr2:81765470-81805799 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024658
protein coding gene Chr2:84884237-84927727 (-)
WSB/EiJ MGP_WSBEiJ_G0025180
protein coding gene Chr2:85422076-85463651 (-)



Homology
more
  • Human Ortholog
    P2RX3, purinergic receptor P2X 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    P2RX3, purinergic receptor P2X 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    P2X3
  • Links
    NCBI Gene ID: 5024
    neXtProt AC: NX_P56373
    UniProt: P56373

  • Chr Location
    11q12.1; chr11:57335943-57372399 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show normal ventilatory responses to hypoxia. Mice homozygous for a reporter allele show loss of rapidly desensitizing ATP-gated cation currents in dorsal root ganglion neurons, reduced formalin-evoked pain behavior, and enhanced thermal hyperalgesia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027071 Ensembl Gene Model | MGI Sequence Detail 38880 C57BL/6J ±  kb
transcript ENSMUST00000028465 Ensembl | MGI Sequence Detail 1812 Not Applicable  
polypeptide ENSMUSP00000028465 Ensembl | MGI Sequence Detail 397 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    Genomic 3
    cDNA 9
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1926054
References
more
  • Summaries
    All 81
    Developmental Gene Expression 19
    Gene Ontology 19
    Phenotypes 23
  • Earliest
    J:42467 Souslova V, et al., Structure and chromosomal mapping of the mouse P2X3 gene. Gene. 1997 Aug 11;195(1):101-11
  • Latest
    J:260552 Donnelly CR, et al., Biphasic functions for the GDNF-Ret signaling pathway in chemosensory neuron development and diversification. Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E516-E525

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory