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P2rx3
Gene Detail
 Symbol
Name
ID
P2rx3
purinergic receptor P2X, ligand-gated ion channel, 3
MGI:1097160
Synonyms 4930513E20Rik, MGC:28163, P2X3
Feature Type protein coding gene
Genetic Map
Chromosome 2
49.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:84998583-85037462 bp, - strand
From VEGA annotation of GRCm38

  38880 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1922  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: P2X purinoceptor
Gene Tree: P2rx3

Human
homologs
Human Homolog P2RX3, purinergic receptor P2X, ligand-gated ion channel, 3
NCBI Gene ID 5024
neXtProt AC  NX_P56373
Human Synonyms  P2X3
Human Chr (Location)  11q12; chr11:57338367-57370076 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Genomic Mutations involving P2rx3 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show normal ventilatory responses to hypoxia. Mice homozygous for a reporter allele show loss of rapidly desensitizing ATP-gated cation currents in dorsal root ganglion neurons, reduced formalin-evoked pain behavior, and enhanced thermal hyperalgesia.
 
Interactions
P2rx3 interacts with 77 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process behavioral response to pain, cation transport, ...
Component axon, dendritic spine, ...
Function ATP binding, extracellular ATP-gated cation channel activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (51)    Tissues (10)    Images (19)
Theiler Stages: 3, 5, 23
Assay TypeResults
RNA in situ 48
RT-PCR 3
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) Genomic(3) cDNA(7) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000013455 (Evidence)
Ensembl Gene ModelENSMUSG00000027071 (Evidence)
Entrez Gene228139 (Evidence)
DFCITC1587208, TC1594214, TC1608517, TC1657990
DoTSDT.40143995, DT.55154602
NIA Mouse Gene IndexU022821, U022822, U341311
Consensus CDS ProjectCCDS16200.1
International Mouse Knockout Project StatusP2rx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013455 VEGA Gene Model | MGI Sequence Detail 38880 C57BL/6J ±  kb
transcript OTTMUST00000032530 VEGA | MGI Sequence Detail 1812 Not Applicable 
polypeptide OTTMUSP00000014450 VEGA | MGI Sequence Detail 397 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003046 P2X3 purinoceptor
InterPro IPR001429 P2X purinoreceptor
InterPro IPR027309 P2X purinoreceptor extracellular domain
Protein Ontology PR:000012190 P2X purinoceptor 3
References (Earliest) J:42467 Souslova V, et al., Structure and chromosomal mapping of the mouse P2X3 gene. Gene. 1997 Aug 11;195(1):101-11
(Latest) J:206879 Huang T, et al., BDNF and NT4 play interchangeable roles in gustatory development. Dev Biol. 2014 Feb 15;386(2):308-20
All references(63)
Other
accession IDs
MGI:1926054

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory