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Ppef1 Gene Detail
Summary
  • Symbol
    Ppef1
  • Name
    protein phosphatase with EF hand calcium-binding domain 1
  • Synonyms
    PPEF 1, PPEF-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097157
    NCBI Gene: 237178
  • Gene Overview
    MyGene.info: PPEF1
Location & Maps
more
  • Sequence Map
    ChrX:160623094-160735765 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      112672 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 73.95 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PPEF1, protein phosphatase with EF-hand domain 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPEF1, protein phosphatase with EF-hand domain 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PP7, PPEF, PPP7C, PPP7CA
  • Links
    NCBI Gene ID: 5475
    neXtProt AC: NX_O14829

  • Chr Location
    Xp22; chrX:18675909-18827921 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    5 phenotype references
  • All Mutations and Alleles
    4
  • Gene trapped
    1
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Ppef1
  • Incidental Mutations
    APF
Homozygous null female and hemizygous null male mice are viable, fertile and display no overt abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019590 VEGA Gene Model | MGI Sequence Detail 112672 C57BL/6J ±  kb
transcript OTTMUST00000046800 VEGA | MGI Sequence Detail 2483 Not Applicable  
polypeptide OTTMUSP00000021163 VEGA | MGI Sequence Detail 650 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    369 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013066 serine/threonine-protein phosphatase with EF-hands 1
  • EC
  • InterPro Domains
    IPR004843 Calcineurin-like phosphoesterase domain, apaH type
    IPR018247 EF-Hand 1, calcium-binding site
    IPR002048 EF-hand domain
    IPR011992 EF-hand domain pair
    IPR000048 IQ motif, EF-hand binding site
    IPR029052 Metallo-dependent phosphatase-like
    IPR013235 PPP domain
    IPR012008 Serine/threonine-protein phosphatase with EF-hands
    IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Molecular
Reagents
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  • All nucleic 8
    cDNA 7
    Other 1

    Microarray probesets 1
References
more
  • Summaries
    All 24
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:42619 Banfi S, et al., Drosophila-related expressed sequences. Hum Mol Genet. 1997;6(10):1745-53
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory