Ptgis
Gene Detail

Symbol Name ID

Ptgis prostaglandin I2 (prostacyclin) synthase MGI:1097156

Synonyms

Cyp8a1, Pgi2, Pgis

Feature Type

protein coding gene

Genetic Map

Chromosome 2

87.22 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:167191805-167240604 bp, - strand From VEGA annotation of GRCm38   48800 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37374  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Protein SuperFamily: cytochrome P450, CYP7A1 type
Gene Tree: Ptgis

Human homologs

Human Homolog		PTGIS, prostaglandin I2 (prostacyclin) synthase
NCBI Gene ID		5740
neXtProt AC		NX_Q16647
Human Synonyms		CYP8, CYP8A1, PGIS, PTGI
Human Chr (Location)		20q13.13; chr20:48120411-48184707 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PTGIS

Alleles and phenotypes

All alleles(16) : Targeted(1) Gene trapped(15)
 

Homozygous mutation of this gene results in increased blood urea nitrogen and creatinine levels, thickening of the aorta with age, mildly increased blood pressure, and kidney abnormalities including cysts, fibrosis, necrosis, and renal vascular congestion.

 

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	apoptotic signaling pathway, cellular response to hypoxia, ...
Component	caveola, endoplasmic reticulum, ...
Function	electron carrier activity, heme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (218)    Tissues (119)    Images (34)
Theiler Stages: 10, 11, 13, 18, 22, 23, 25, 28

Assay Type	Results
RNA in situ	206
RT-PCR	12

cDNA source data(57)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(58) cDNA(57) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000001169 (Evidence)
Ensembl Gene Model	ENSMUSG00000017969 (Evidence)
Entrez Gene	19223 (Evidence)
UniGene	2339
DFCI	TC1579541, TC1593815, TC1669146
DoTS	DT.101290601, DT.40148317, DT.531362, DT.97357938
NIA Mouse Gene Index	U023674
EC	5.3.99.4
Consensus CDS Project	CCDS17097.1
International Mouse Knockout Project Status	Ptgis

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001169	VEGA Gene Model | MGI Sequence Detail	48800	C57BL/6J
transcript	OTTMUST00000038851	VEGA | MGI Sequence Detail	1711	Not Applicable
polypeptide	OTTMUSP00000017366	VEGA | MGI Sequence Detail	509	Not Applicable

All sequences(34) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(163 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001128	Cytochrome P450
InterPro	IPR024204	Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
InterPro	IPR002403	Cytochrome P450, E-class, group IV
InterPro	IPR027286	Prostacyclin synthase
Protein Ontology	PR:000013424	prostacyclin synthase

References

(Earliest) J:41092 Kuwamoto S, et al., Inverse gene expression of prostacyclin and thromboxane synthases in resident and activated peritoneal macrophages. FEBS Lett. 1997 Jun 9;409(2):242-6
(Latest) J:195728 Yoshikawa N, et al., Cardiomyocyte-specific overexpression of HEXIM1 prevents right ventricular hypertrophy in hypoxia-induced pulmonary hypertension in mice. PLoS One. 2012;7(12):e52522
All references(40)