About   Help   FAQ
Ptgis
Gene Detail
Symbol

Name
ID
Ptgis
prostaglandin I2 (prostacyclin) synthase
MGI:1097156
Synonyms
Cyp8a1, Pgi2, Pgis
Feature Type
protein coding gene
Genetic Map
Chromosome 2
87.22 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:167191805-167240604 bp, - strand
From VEGA annotation of GRCm38

  48800 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37374  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cytochrome P450, CYP7A1 type
Gene Tree: Ptgis

Human
homologs
Human Homolog PTGIS, prostaglandin I2 (prostacyclin) synthase
NCBI Gene ID 5740
neXtProt AC  NX_Q16647
Human Synonyms  CYP8, CYP8A1, PGIS, PTGI
Human Chr (Location)  20q13.13; chr20:49503874-49568170 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PTGIS
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(15) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in increased blood urea nitrogen and creatinine levels, thickening of the aorta with age, mildly increased blood pressure, and kidney abnormalities including cysts, fibrosis, necrosis, and renal vascular congestion.
 
Interactions
Ptgis interacts with 61 markers (Mir27a, Mir27b, Mir125a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process apoptotic signaling pathway, cellular response to hypoxia, ...
Component caveola, cytoplasm, ...
Function heme binding, iron ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (218)    Tissues (119)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 206
RT-PCR 12
cDNA source data(53)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(54) cDNA(53) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000001169 (Evidence)
Ensembl Gene ModelENSMUSG00000017969 (Evidence)
Entrez Gene19223 (Evidence)
UniGene2339
DFCITC1669146, TC1593815, TC1579541
DoTSDT.101290601, DT.97357938, DT.531362, DT.40148317
NIA Mouse Gene IndexU023674
EC5.3.99.4
Consensus CDS ProjectCCDS17097.1
International Mouse Knockout Project StatusPtgis
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001169 VEGA Gene Model | MGI Sequence Detail 48800 C57BL/6J ±  kb
transcript OTTMUST00000038851 VEGA | MGI Sequence Detail 1711 Not Applicable 
polypeptide OTTMUSP00000017366 VEGA | MGI Sequence Detail 509 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(186 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001128 Cytochrome P450
InterPro IPR024204 Cytochrome P450, cholesterol 7-alpha-monooxygenase-type
InterPro IPR002403 Cytochrome P450, E-class, group IV
InterPro IPR027286 Prostacyclin synthase
Protein Ontology PR:000013424 prostacyclin synthase
References
(Earliest) J:41092 Kuwamoto S, et al., Inverse gene expression of prostacyclin and thromboxane synthases in resident and activated peritoneal macrophages. FEBS Lett. 1997 Jun 9;409(2):242-6
(Latest) J:195728 Yoshikawa N, et al., Cardiomyocyte-specific overexpression of HEXIM1 prevents right ventricular hypertrophy in hypoxia-induced pulmonary hypertension in mice. PLoS One. 2012;7(12):e52522
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory