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Phlda1 Gene Detail
Summary
  • Symbol
    Phlda1
  • Name
    pleckstrin homology like domain, family A, member 1
  • Synonyms
    DT1P1B11, Tdag, TDAG51
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096880
    NCBI Gene: 21664
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:111342147-111344506 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 58.70 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    131 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096880
 protein coding gene Chr10:111342147-111344510 (+)
129S1/SvImJ ENSMUSG00200010410
 protein coding gene Chr10:107760053-107762412 (+)
A/J ENSMUSG00195008110
 protein coding gene Chr10:108175475-108177834 (+)
AKR/J ENSMUSG00220024694
 protein coding gene Chr10:107756868-107759227 (+)
BALB/cJ ENSMUSG00180023398
 protein coding gene Chr10:108194982-108197341 (+)
C3H/HeJ ENSMUSG00175015128
 protein coding gene Chr10:108123379-108125739 (+)
C57BL/6NJ ENSMUSG00215008251
 protein coding gene Chr10:107846323-107848682 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015799
 protein coding gene Chr10:104456355-104458728 (+)
CAST/EiJ ENSTCUG00005011432
 protein coding gene Chr10:107220195-107222571 (+)
CBA/J ENSMUSG00210011468
 protein coding gene Chr10:107994738-107997097 (+)
DBA/2J ENSMUSG00185023659
 protein coding gene Chr10:108124092-108126456 (+)
FVB/NJ ENSMUSG00205009730
 protein coding gene Chr10:107618155-107620514 (+)
JF1/MsJ ENSUMUG00000008152
 protein coding gene Chr10:109447347-109449685 (+)
LP/J ENSMUSG00230011247
 protein coding gene Chr10:110069326-110071685 (+)
NOD/ShiLtJ ENSMUSG00190020083
 protein coding gene Chr10:108222433-108224792 (+)
NZO/HlLtJ ENSMUSG00225016312
 protein coding gene Chr10:114323628-114325987 (+)
PWK/PhJ ENSLUMG00010013307
 protein coding gene Chr10:107827772-107830134 (+)
SPRET/EiJ ENSMSPG00010005302
 protein coding gene Chr10:109648230-109649890 (+)
WSB/EiJ ENSIUOG00005009931
 protein coding gene Chr10:107895963-107898325 (+)



Homology
more
  • Human Ortholog
    PHLDA1, pleckstrin homology like domain family A member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PHLDA1, pleckstrin homology like domain family A member 1
  • Synonyms
    DT1P1B11, PHRIP, TDAG51
  • Links
    NCBI Gene ID: 22822
    UniProt: Q8WV24

  • Chr Location
    12q21.2; chr12:76025447-76031776 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    17 phenotype references
Mice homozygous for a targeted null mutation are viable, fertile and morphologically normal. Relative to wild-type littermates, homozygous null mice display no obvious defects in immune function, Fas expression or T-cell apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1177
  • Tissues
    80
  • cDNA Data
    58
  • Literature Summary
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020205 Ensembl Gene Model | MGI Sequence Detail 2360 C57BL/6J ±  kb
transcript ENSMUST00000164773 Ensembl | MGI Sequence Detail 1949 Not Applicable  
polypeptide ENSMUSP00000132815 Ensembl | MGI Sequence Detail 405 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 59
    cDNA 59

    Microarray probesets 3
References
more
  • Summaries
    All 57
    Developmental Gene Expression 10
    Gene Ontology 9
    Phenotypes 17
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:363446 Yousof TR, et al., Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice. J Biol Chem. 2024 Feb;300(2):105655
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory