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Etv5
Gene Detail
Symbol

Name
ID
Etv5
ets variant 5
MGI:1096867
Synonyms
1110005E01Rik, 8430401F14Rik, erm
Feature Type
protein coding gene
Genetic Map
Chromosome 16
13.30 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:22381309-22439719 bp, - strand
From VEGA annotation of GRCm38

  58411 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3276  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: ETV5
Protein SuperFamily: transcription factor ER81
Gene Tree: Etv5

Human
homologs
ETV5, ets variant 5
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2119
neXtProt AC: NX_P41161

Human Synonyms: ERM

Human Chr (Location): 3q28; chr3:186046317-186109112 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(429) : Chemically induced (ENU)(1) Gene trapped(422) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display either male infertility, small testes, azoospermia, and failure to maintain spermatogonia or they are prenatally lethal. Preaxial polydactyly has also been observed.
 
Interactions
Etv5 interacts with 300 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cell differentiation, cellular response to oxidative stress, ...
Component nucleus
Function DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (142 records)
Data Summary: Results (491)    Tissues (280)    Images (92)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 467
Northern blot 11
RT-PCR 13
cDNA source data(162)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA ETV5 ZFIN etv5a    NEW 
Molecular
reagents
All nucleic(171) cDNA(162) Primer pair(5) Other(4)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000036714 (Evidence)
Ensembl Gene Model ENSMUSG00000013089 (Evidence)
Entrez Gene 104156 (Evidence)
UniGene 155708
DFCI TC1572047
NIA Mouse Gene Index U055077, U036911
Consensus CDS Project CCDS37299.1
International Mouse Phenotyping Consortium Status Etv5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036714 VEGA Gene Model | MGI Sequence Detail 58411 C57BL/6J ±  kb
transcript OTTMUST00000094063 VEGA | MGI Sequence Detail 3773 Not Applicable 
polypeptide OTTMUSP00000052255 VEGA | MGI Sequence Detail 528 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(410 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR006715 PEA3-type ETS-domain transcription factor, N-terminal
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007228 ETS translocation variant 5
References
(Earliest) J:42463 Chotteau-Lelievre A, et al., Differential expression patterns of the PEA3 group transcription factors through murine embryonic development. Oncogene. 1997 Aug 18;15(8):937-52
(Latest) J:220469 Grego-Bessa J, et al., Morphogenesis of the mouse neural plate depends on distinct roles of cofilin 1 in apical and basal epithelial domains. Development. 2015 Apr 1;142(7):1305-14
All references(189)
Other
accession IDs
MGI:1915818, MGI:1923002

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory