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Etv5
Gene Detail
Symbol

Name
ID
Etv5
ets variant 5
MGI:1096867
Synonyms
1110005E01Rik, 8430401F14Rik, erm
Feature Type
protein coding gene
Genetic Map
Chromosome 16
13.30 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:22381309-22439719 bp, - strand
From VEGA annotation of GRCm38

  58411 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3276  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transcription factor ER81
Gene Tree: Etv5

Human
homologs
Human Homolog ETV5, ets variant 5
NCBI Gene ID 2119
neXtProt AC  NX_P41161
Human Synonyms  ERM
Human Chr (Location)  3q28; chr3:186046317-186109112 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(429) : Chemically induced (ENU)(1) Gene trapped(422) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display either male infertility, small testes, azoospermia, and failure to maintain spermatogonia or they are prenatally lethal. Preaxial polydactyly has also been observed.
 
Interactions
Etv5 interacts with 300 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cell differentiation, cellular response to oxidative stress, ...
Component nucleus
Function DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (123 records)
Data Summary: Results (481)    Tissues (279)    Images (83)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 459
Northern blot 11
RT-PCR 11
cDNA source data(162)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(169) cDNA(162) Primer pair(4) Other(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000036714 (Evidence)
Ensembl Gene ModelENSMUSG00000013089 (Evidence)
Entrez Gene104156 (Evidence)
UniGene155708
DFCITC1572047
NIA Mouse Gene IndexU036911, U055077
Consensus CDS ProjectCCDS37299.1
International Mouse Knockout Project StatusEtv5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036714 VEGA Gene Model | MGI Sequence Detail 58411 C57BL/6J ±  kb
transcript OTTMUST00000094063 VEGA | MGI Sequence Detail 3773 Not Applicable 
polypeptide OTTMUSP00000052255 VEGA | MGI Sequence Detail 528 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(410 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000418 Ets domain
InterPro IPR006715 PEA3-type ETS-domain transcription factor, N-terminal
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000007228 ETS translocation variant 5
References
(Earliest) J:42463 Chotteau-Lelievre A, et al., Differential expression patterns of the PEA3 group transcription factors through murine embryonic development. Oncogene. 1997 Aug 18;15(8):937-52
(Latest) J:207688 Gutierrez-Aguilar R, et al., The role of the transcription factor ETV5 in insulin exocytosis. Diabetologia. 2014 Feb;57(2):383-91
All references(172)
Other
accession IDs
MGI:1915818, MGI:1923002

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory