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Etv5 Gene Detail
Summary
  • Symbol
    Etv5
  • Name
    ets variant 5
  • Synonyms
    1110005E01Rik, 8430401F14Rik, erm
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096867
    NCBI Gene: 104156
  • Gene Overview
    MyGene.info: ETV5
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:22381313-22439570 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 13.30 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    410 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096867
protein coding gene Chr16:22381309-22439719 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022669
protein coding gene Chr16:19883369-19949035 (-)
A/J MGP_AJ_G0022630
protein coding gene Chr16:18918485-18976096 (-)
AKR/J MGP_AKRJ_G0022605
protein coding gene Chr16:19706168-19770603 (-)
BALB/cJ MGP_BALBcJ_G0022635
protein coding gene Chr16:19112646-19172460 (-)
C3H/HeJ MGP_C3HHeJ_G0022399
protein coding gene Chr16:19824265-19884892 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023085
protein coding gene Chr16:20313957-20381744 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020603
protein coding gene Chr16:19612476-19671412 (-)
CAST/EiJ MGP_CASTEiJ_G0021929
protein coding gene Chr16:19802576-19864498 (-)
CBA/J MGP_CBAJ_G0022371
protein coding gene Chr16:21166288-21243460 (-)
DBA/2J MGP_DBA2J_G0022503
protein coding gene Chr16:18891695-18953008 (-)
FVB/NJ MGP_FVBNJ_G0022479
protein coding gene Chr16:18864535-18921535 (-)
LP/J MGP_LPJ_G0022571
protein coding gene Chr16:19631358-19695128 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022498
protein coding gene Chr16:20736567-20798001 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023096
protein coding gene Chr16:19665024-19730931 (-)
PWK/PhJ MGP_PWKPhJ_G0021669
protein coding gene Chr16:19139973-19197189 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021499
protein coding gene Chr16:19438684-19503256 (-)
WSB/EiJ MGP_WSBEiJ_G0021972
protein coding gene Chr16:19619181-19681346 (-)



Homology
more
  • Human Ortholog
    ETV5, ETS variant 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ETV5, ETS variant 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ERM
  • Links
    NCBI Gene ID: 2119
    neXtProt AC: NX_P41161
    UniProt: P41161

  • Chr Location
    3q27.2; chr3:186046317-186109112 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 4 alleles in 4 genetic backgrounds
    15 phenotypes from multigenic genotypes
    2 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display either male infertility, small testes, azoospermia, and failure to maintain spermatogonia or they are prenatally lethal. Preaxial polydactyly has also been observed.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 104156 NCBI Gene Model | MGI Sequence Detail 58258 C57BL/6J ±  kb
    transcript NM_001358428 RefSeq | MGI Sequence Detail 4865 C57BL/6  
    polypeptide Q9CXC9 UniProt | EBI | MGI Sequence Detail 510 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR000418 Ets domain
      IPR006715 PEA3-type ETS-domain transcription factor, N-terminal
      IPR036390 Winged helix DNA-binding domain superfamily
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 174
      cDNA 163
      Primer pair 5
      Other 6

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1915818, MGI:1923002
    References
    more
    • Summaries
      All 241
      Developmental Gene Expression 178
      Gene Ontology 9
      Phenotypes 32
    • Earliest
      J:42463 Chotteau-Lelievre A, et al., Differential expression patterns of the PEA3 group transcription factors through murine embryonic development. Oncogene. 1997 Aug 18;15(8):937-52
    • Latest
      J:263981 Benhamouche-Trouillet S, et al., Proliferation-independent role of NF2 (merlin) in limiting biliary morphogenesis. Development. 2018 Apr 30;145(9)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory