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Entpd2 Gene Detail
Summary
  • Symbol
    Entpd2
  • Name
    ectonucleoside triphosphate diphosphohydrolase 2
  • Synonyms
    Cd39l1, NTPDase2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096863
    NCBI Gene: 12496
  • Gene Overview
    MyGene.info: ENTPD2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25395874-25401321 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 17.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    40 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096863
protein coding gene Chr2:25395874-25401323 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025443
protein coding gene Chr2:23280199-23285646 (+)
A/J MGP_AJ_G0025420
protein coding gene Chr2:22379376-22384831 (+)
AKR/J MGP_AKRJ_G0025390
protein coding gene Chr2:23126359-23131814 (+)
BALB/cJ MGP_BALBcJ_G0025416
protein coding gene Chr2:22492538-22497985 (+)
C3H/HeJ MGP_C3HHeJ_G0025177
protein coding gene Chr2:23063955-23069402 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025860
protein coding gene Chr2:24029442-24034889 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023271
protein coding gene Chr2:21290428-21295887 (+)
CAST/EiJ MGP_CASTEiJ_G0024640
protein coding gene Chr2:22941799-22947251 (+)
CBA/J MGP_CBAJ_G0025155
protein coding gene Chr2:24857616-24863063 (+)
DBA/2J MGP_DBA2J_G0025288
protein coding gene Chr2:22218786-22224241 (+)
FVB/NJ MGP_FVBNJ_G0025250
protein coding gene Chr2:21961458-21966905 (+)
LP/J MGP_LPJ_G0025374
protein coding gene Chr2:23223745-23229192 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025281
protein coding gene Chr2:25049844-25055299 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025919
protein coding gene Chr2:23079836-23085283 (+)
PWK/PhJ MGP_PWKPhJ_G0024388
protein coding gene Chr2:22039806-22045301 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024188
protein coding gene Chr2:23223350-23228756 (+)
WSB/EiJ MGP_WSBEiJ_G0024709
protein coding gene Chr2:23153866-23159321 (+)



Homology
more
  • Human Ortholog
    ENTPD2, ectonucleoside triphosphate diphosphohydrolase 2
  • Vertebrate Orthologs
    12
  • Human Ortholog
    ENTPD2, ectonucleoside triphosphate diphosphohydrolase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD39L1, NTPDase-2
  • Links
    NCBI Gene ID: 954
    neXtProt AC: NX_Q9Y5L3
    UniProt: Q9Y5L3

  • Chr Location
    9q34.3; chr9:137048098-137054051 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display smaller circumvallate papilla size and reduced neural responses to taste stimuli.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015085 Ensembl Gene Model | MGI Sequence Detail 5448 C57BL/6J ±  kb
    transcript ENSMUST00000028328 Ensembl | MGI Sequence Detail 1935 Not Applicable  
    polypeptide ENSMUSP00000028328 Ensembl | MGI Sequence Detail 495 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 1
      cDNA 46

      Microarray probesets 4
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 3
    • Earliest
      J:42383 Chadwick BP, et al., Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes. Mamm Genome. 1997 Sep;8(9):668-72
    • Latest
      J:222058 Gampe K, et al., NTPDase2 and purinergic signaling control progenitor cell proliferation in neurogenic niches of the adult mouse brain. Stem Cells. 2015 Jan;33(1):253-64

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory