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Entpd2 Gene Detail
Summary
  • Symbol
    Entpd2
  • Name
    ectonucleoside triphosphate diphosphohydrolase 2
  • Synonyms
    Cd39l1, NTPDase2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096863
    NCBI Gene: 12496
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25285886-25291333 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 17.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    169 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096863
 protein coding gene Chr2:25285886-25291335 (+)
129S1/SvImJ ENSMUSG00200048822
 protein coding gene Chr2:22270053-22275500 (+)
A/J ENSMUSG00195039865
 protein coding gene Chr2:22360021-22365476 (+)
AKR/J ENSMUSG00220050589
 protein coding gene Chr2:22477852-22483307 (+)
BALB/cJ ENSMUSG00180053172
 protein coding gene Chr2:22371677-22377124 (+)
C3H/HeJ ENSMUSG00175051205
 protein coding gene Chr2:22335828-22341275 (+)
C57BL/6NJ ENSMUSG00215045355
 protein coding gene Chr2:22394570-22400017 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023271
 protein coding gene Chr2:21290428-21295887 (+)
CAST/EiJ ENSTCUG00005051323
 protein coding gene Chr2:22119855-22125307 (+)
CBA/J ENSMUSG00210016428
 protein coding gene Chr2:22374836-22380283 (+)
DBA/2J ENSMUSG00185050676
 protein coding gene Chr2:22274237-22279692 (+)
FVB/NJ ENSMUSG00205036426
 protein coding gene Chr2:22128667-22134115 (+)
JF1/MsJ ENSUMUG00000055823
 protein coding gene Chr2:22189467-22194962 (+)
LP/J ENSMUSG00230042176
 protein coding gene Chr2:24206039-24211486 (+)
NOD/ShiLtJ ENSMUSG00190035686
 protein coding gene Chr2:22365103-22370558 (+)
NZO/HlLtJ ENSMUSG00225010527
 protein coding gene Chr2:31956447-31961894 (+)
PWK/PhJ ENSLUMG00010043734
 protein coding gene Chr2:22286856-22292351 (+)
SPRET/EiJ ENSMSPG00010031795
 protein coding gene Chr2:22974010-22979416 (+)
WSB/EiJ ENSIUOG00005050631
 protein coding gene Chr2:22232365-22237820 (+)



Homology
more
  • Human Ortholog
    ENTPD2, ectonucleoside triphosphate diphosphohydrolase 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ENTPD2, ectonucleoside triphosphate diphosphohydrolase 2
  • Synonyms
    CD39L1, NTPDase-2
  • Links
    NCBI Gene ID: 954
    UniProt: Q9Y5L3

  • Chr Location
    9q34.3; chr9:137048107-137054061 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ENTPD2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display smaller circumvallate papilla size and reduced neural responses to taste stimuli.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    82
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    727
  • Tissues
    100
  • cDNA Data
    44
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015085 Ensembl Gene Model | MGI Sequence Detail 5448 C57BL/6J ±  kb
    transcript ENSMUST00000028328 Ensembl | MGI Sequence Detail 1935 Not Applicable  
    polypeptide ENSMUSP00000028328 Ensembl | MGI Sequence Detail 495 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000007093 ectonucleoside triphosphate diphosphohydrolase 2
      (term hierarchy)
    • EC
      3.6.1.5
    • InterPro Domains
      IPR000407 Nucleoside phosphatase GDA1/CD39
    • GlyGen
      O55026 7 sites, 15 N-linked glycans (5 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 1
      cDNA 46
      Antibodies 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 12
      Gene Ontology 16
      Phenotypes 6
    • Earliest
      J:42383 Chadwick BP, et al., Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes. Mamm Genome. 1997 Sep;8(9):668-72
    • Latest
      J:381475 Kelestemur T, et al., NTPDase8 Protects Against Liver Ischemia-Reperfusion Injury in Mice. FASEB J. 2025 Jul 15;39(13):e70775
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory