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Psmd2 Gene Detail
Summary
  • Symbol
    Psmd2
  • Name
    proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
  • Synonyms
    9430095H01Rik, TEG-190, Tex190
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096584
    NCBI Gene: 21762
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:20470402-20482164 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 12.49 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    325 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096584
 protein coding gene Chr16:20469872-20482164 (+)
129S1/SvImJ ENSMUSG00200045787
 protein coding gene Chr16:17467876-17479640 (+)
A/J ENSMUSG00195029506
 protein coding gene Chr16:17025430-17037408 (+)
AKR/J ENSMUSG00220037275
 protein coding gene Chr16:17343108-17354874 (+)
BALB/cJ ENSMUSG00180032947
 protein coding gene Chr16:17266678-17278447 (+)
C3H/HeJ ENSMUSG00175045027
 protein coding gene Chr16:17411732-17423498 (+)
C57BL/6NJ ENSMUSG00215036190
 protein coding gene Chr16:17132684-17144450 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020584
 protein coding gene Chr16:17814667-17826939 (+)
CAST/EiJ ENSTCUG00005042065
 protein coding gene Chr16:17740661-17752445 (+)
CBA/J ENSMUSG00210043921
 protein coding gene Chr16:17433483-17445250 (+)
DBA/2J ENSMUSG00185027835
 protein coding gene Chr16:17372244-17384010 (+)
FVB/NJ ENSMUSG00205032765
 protein coding gene Chr16:17375000-17386766 (+)
JF1/MsJ ENSUMUG00000028480
 protein coding gene Chr16:17564476-17576226 (+)
LP/J ENSMUSG00230040560
 protein coding gene Chr16:19951496-19963262 (+)
NOD/ShiLtJ ENSMUSG00190045105
 protein coding gene Chr16:17513763-17525530 (+)
NZO/HlLtJ ENSMUSG00225037005
 protein coding gene Chr16:23197294-23209056 (+)
PWK/PhJ ENSLUMG00010047246
 protein coding gene Chr16:17391475-17403228 (+)
SPRET/EiJ ENSMSPG00010045797
 protein coding gene Chr16:17253664-17265440 (+)
WSB/EiJ ENSIUOG00005032954
 protein coding gene Chr16:17607343-17619317 (+)



Homology
more
  • Human Ortholog
    PSMD2, proteasome 26S subunit ubiquitin receptor, non-ATPase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSMD2, proteasome 26S subunit ubiquitin receptor, non-ATPase 2
  • Synonyms
    P97, RPN1, S2, TRAP2
  • Links
    NCBI Gene ID: 5708
    UniProt: Q13200

  • Chr Location
    3q27.1; chr3:184299157-184309054 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    608
  • Tissues
    7
  • cDNA Data
    440
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000006998 Ensembl Gene Model | MGI Sequence Detail 11763 C57BL/6J ±  kb
transcript ENSMUST00000007212 Ensembl | MGI Sequence Detail 2961 Not Applicable  
polypeptide ENSMUSP00000007212 Ensembl | MGI Sequence Detail 908 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    15 Sequences
  • Protein Ontology
    PR:000002180 26S proteasome non-ATPase regulatory subunit 2
    (term hierarchy)
  • InterPro Domains
    IPR041433 26S proteasome non-ATPase regulatory subunit RPN1, C-terminal
    IPR016643 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit
    IPR011989 Armadillo-like helical
    IPR016024 Armadillo-type fold
    IPR002015 Proteasome/cyclosome repeat
    IPR040892 RPN1, N-terminal
  • GlyGen
    Q8VDM4 2 sites, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 441
    cDNA 441

    Microarray probesets 4
Other
Accession IDs
less
MGI:1924684, MGI:2146329
References
more
  • Summaries
    All 52
    Developmental Gene Expression 4
    Gene Ontology 11
    Phenotypes 10
  • Earliest
    J:35463 Lopez-Fernandez LA, et al., Characterization of genes expressed early in mouse spermatogenesis, isolated from a subtractive cDNA library. Mamm Genome. 1996 Sep;7(9):698-700
  • Latest
    J:367356 Yue WY, et al., Non-Redundant Essential Roles of Proteasomal Ubiquitin Receptors Rpn10 and Rpn13 in Germ Cell Formation and Fertility. Cells. 2025 May 12;14(10)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory