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Lasp1
Gene Detail
Symbol

Name
ID
Lasp1
LIM and SH3 protein 1
MGI:109656
Synonyms
Def-4, SH3P6, Tg(11Col1a1)NG, Tg(Col1a1-lacZ)1Ngma
Feature Type
protein coding gene
Genetic Map
Chromosome 11
61.10 cM, cytoband C-D
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:97799000-97838764 bp, + strand
From VEGA annotation of GRCm38

  39765 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4480  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LASP1
Gene Tree: Lasp1

Human
homologs
LASP1, LIM and SH3 protein 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3927
neXtProt AC: NX_Q14847

Human Synonyms: Lasp-1, MLN50

Human Chr (Location): 17q11-q21.3; chr17:38869859-38921770 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(265) : Gene trapped(261) Targeted(3) Transgenic(1)
Genomic Mutations involving Lasp1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit reduced histamine-stimulated gastric acid secretion and enlarged heart and testes on a mixed background. Mice homozygous for a transgene insertion exhibit abnormal tail vertebrae with scoliosis, transient spina bifida occulta, and a bent tail.
 
Interactions
Lasp1 interacts with 253 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process ion transmembrane transport, ion transport, ...
Component cortical actin cytoskeleton, cytoplasm, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (105)    Tissues (90)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 60
Northern blot 33
RT-PCR 12
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lasp1 ; ZFIN lasp1    NEW 
Molecular
reagents
All nucleic(19) cDNA(17) Primer pair(2)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000002777 (Evidence)
Ensembl Gene Model ENSMUSG00000038366 (Evidence)
Entrez Gene 16796 (Evidence)
DFCI TC1573760, TC1720603, TC1727631
DoTS DT.101406163, DT.110543693, DT.535667, DT.94211535, DT.94211583, DT.94211590, DT.97368953
Consensus CDS Project CCDS25332.1
International Mouse Phenotyping Consortium Status Lasp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002777 VEGA Gene Model | MGI Sequence Detail 39765 C57BL/6J ±  kb
transcript OTTMUST00000005566 VEGA | MGI Sequence Detail 3540 Not Applicable 
polypeptide OTTMUSP00000002658 VEGA | MGI Sequence Detail 263 Not Applicable 

For the selected sequences
All sequences(136) RefSeq(6) UniProt(14)
Polymorphisms
SNPs within 2kb(251 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000900 Nebulin repeat
InterPro IPR001452 SH3 domain
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009676 LIM and SH3 domain protein 1
References
(Earliest) J:35786 Sparks AB, et al., Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat Biotechnol. 1996 Jun;14(6):741-4
(Latest) J:208050 Huang TN, et al., Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality. Nat Neurosci. 2014 Feb;17(2):240-7
All references(53)
Other
accession IDs
MGD-MRK-39655, MGI:2143983, MGI:2429540

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory