About   Help   FAQ
Lasp1
Gene Detail
Symbol

Name
ID
Lasp1
LIM and SH3 protein 1
MGI:109656
Synonyms
Def-4, SH3P6, Tg(11Col1a1)NG, Tg(Col1a1-lacZ)1Ngma
Feature Type
protein coding gene
Genetic Map
Chromosome 11
61.10 cM, cytoband C-D
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:97799000-97838764 bp, + strand
From VEGA annotation of GRCm38

  39765 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4480  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lasp1

Human
homologs
Human Homolog LASP1, LIM and SH3 protein 1
NCBI Gene ID 3927
neXtProt AC  NX_Q14847
Human Synonyms  Lasp-1, MLN50
Human Chr (Location)  17q11-q21.3; chr17:38869859-38921770 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(264) : Gene trapped(261) Targeted(2) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced histamine-stimulated gastric acid secretion and enlarged heart and testes on a mixed background. Mice homozygous for a transgene insertion exhibit abnormal tail vertebrae with scoliosis, transient spina bifida occulta, and a bent tail.
 
Interactions
Lasp1 interacts with 254 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process ion transmembrane transport, ion transport, ...
Component cortical actin cytoskeleton, cytoplasm, ...
Function actin binding, actin filament binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (105)    Tissues (90)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 60
Northern blot 33
RT-PCR 12
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(17) Primer pair(2)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000002777 (Evidence)
Ensembl Gene ModelENSMUSG00000038366 (Evidence)
Entrez Gene16796 (Evidence)
DFCITC1727631, TC1720603, TC1573760
DoTSDT.110543693, DT.101406163, DT.535667, DT.94211583, DT.94211535, DT.94211590, DT.97368953
Consensus CDS ProjectCCDS25332.1
International Mouse Knockout Project StatusLasp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002777 VEGA Gene Model | MGI Sequence Detail 39765 C57BL/6J ±  kb
transcript OTTMUST00000005566 VEGA | MGI Sequence Detail 3540 Not Applicable 
polypeptide OTTMUSP00000002658 VEGA | MGI Sequence Detail 263 Not Applicable 

For the selected sequences
All sequences(146) RefSeq(6) UniProt(27)
Polymorphisms
SNPs within 2kb(251 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000900 Nebulin 35 residue motif
InterPro IPR001452 Src homology-3 domain
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009676 LIM and SH3 domain protein 1
References
(Earliest) J:35786 Sparks AB, et al., Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat Biotechnol. 1996 Jun;14(6):741-4
(Latest) J:196968 Campolo F, et al., Essential role of sox2 for the establishment and maintenance of the germ cell line. Stem Cells. 2013 Apr 3;
All references(54)
Other
accession IDs
MGD-MRK-39655, MGI:2143983, MGI:2429540

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/11/2014
MGI 5.20
The Jackson Laboratory