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Lasp1 Gene Detail
Summary
  • Symbol
    Lasp1
  • Name
    LIM and SH3 protein 1
  • Synonyms
    Def-4, SH3P6, Tg(11Col1a1)NG, Tg(Col1a1-lacZ)1Ngma
  • Feature Type
    protein coding gene
  • IDs
    MGI:109656
    NCBI Gene: 16796
  • Gene Overview
    MyGene.info: LASP1
  • Alliance
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:97799005-97838765 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 61.10 cM, cytoband C-D
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    249 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109656
protein coding gene Chr11:97799000-97838765 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019042
protein coding gene Chr11:100274982-100317937 (+)
A/J MGP_AJ_G0019010
protein coding gene Chr11:96126879-96167489 (+)
AKR/J MGP_AKRJ_G0018980
protein coding gene Chr11:99111643-99151755 (+)
BALB/cJ MGP_BALBcJ_G0018983
protein coding gene Chr11:96627100-96666814 (+)
C3H/HeJ MGP_C3HHeJ_G0018797
protein coding gene Chr11:99234976-99276825 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019436
protein coding gene Chr11:103364235-103406073 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017067
protein coding gene Chr11:93581397-93621733 (+)
CAST/EiJ MGP_CASTEiJ_G0018351
protein coding gene Chr11:100100285-100138369 (+)
CBA/J MGP_CBAJ_G0018768
protein coding gene Chr11:107647703-107690217 (+)
DBA/2J MGP_DBA2J_G0018876
protein coding gene Chr11:95682449-95722517 (+)
FVB/NJ MGP_FVBNJ_G0018865
protein coding gene Chr11:95175280-95216525 (+)
LP/J MGP_LPJ_G0018946
protein coding gene Chr11:100771022-100813074 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018892
protein coding gene Chr11:107462007-107502689 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019476
protein coding gene Chr11:99419586-99460456 (+)
PWK/PhJ MGP_PWKPhJ_G0018123
protein coding gene Chr11:96665012-96706360 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017913
protein coding gene Chr11:99135674-99180554 (+)
WSB/EiJ MGP_WSBEiJ_G0018401
protein coding gene Chr11:99316480-99360033 (+)



Homology
more
  • Human Ortholog
    LASP1, LIM and SH3 protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LASP1, LIM and SH3 protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Lasp-1, MLN50
  • Links
    NCBI Gene ID: 3927
    neXtProt AC: NX_Q14847
    UniProt: Q14847

  • Chr Location
    17q12; chr17:38869859-38921770 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4480
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LASP1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 2 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced histamine-stimulated gastric acid secretion and enlarged heart and testes on a mixed background. Mice homozygous for a transgene insertion exhibit abnormal tail vertebrae with scoliosis, transient spina bifida occulta, and a bent tail.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16796 NCBI Gene Model | MGI Sequence Detail 39761 C57BL/6J ±  kb
    transcript NM_010688 RefSeq | MGI Sequence Detail 3557 C57BL/6  
    polypeptide Q61792 UniProt | EBI | MGI Sequence Detail 263 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 18
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-39655, MGI:2143983, MGI:2429540
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 15
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:35786 Sparks AB, et al., Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat Biotechnol. 1996 Jun;14(6):741-4
    • Latest
      J:242317 Tan J, et al., Lacking of palladin leads to multiple cellular events changes which contribute to NTD. Neural Dev. 2017 Mar 24;12(1):4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory