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Morf4l1 Gene Detail
Summary
  • Symbol
    Morf4l1
  • Name
    mortality factor 4 like 1
  • Synonyms
    MORFRG15, MRG15, TEG-189, Tex189
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096551
    NCBI Gene: 21761
  • Gene Overview
    MyGene.info: MORF4L1
Location & Maps
more
  • Sequence Map
    Chr9:90091665-90114774 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23110 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 47.42 cM, cytoband D1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MORF4L1, mortality factor 4 like 1
  • Vertebrate Orthologs
    5
  • Human Ortholog
    MORF4L1, mortality factor 4 like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Eaf3, FWP006, HsT17725, MEAF3, MORFRG15, MRG15, S863-6
  • Links
    NCBI Gene ID: 10933
    neXtProt AC: NX_Q9UBU8

  • Chr Location
    15q24; chr15:78872781-78897739 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    74
  • Chemically induced (other)
    1
  • Gene trapped
    72
  • Targeted
    1
  • Genomic Mutations
    1 involving Morf4l1
  • Incidental Mutations
Homozygous null mice display perinatal lethality, cardiac hypertrophy, reduced alveolar space, decreased cell proliferation, congestion of the liver, lung, and spleen, skin edema, and thin skin.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046589 VEGA Gene Model | MGI Sequence Detail 23110 C57BL/6J ±  kb
transcript OTTMUST00000121135 VEGA | MGI Sequence Detail 1882 Not Applicable  
polypeptide OTTMUSP00000066856 VEGA | MGI Sequence Detail 362 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    93 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    cDNA 30

    Microarray probesets 6
References
more
  • Summaries
    All 45
    Developmental Gene Expression 7
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:35463 Lopez-Fernandez LA, et al., Characterization of genes expressed early in mouse spermatogenesis, isolated from a subtractive cDNA library. Mamm Genome. 1996 Sep;7(9):698-700
  • Latest
    J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory