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Cd81 Gene Detail
Summary
  • Symbol
    Cd81
  • Name
    CD81 antigen
  • Synonyms
    Tapa1, Tapa-1, Tspan28
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096398
    NCBI Gene: 12520
Location & Maps
more
  • Sequence Map
    Chr7:143052739-143067934 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15196 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    CD81, CD81 molecule
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CD81, CD81 molecule
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CVID6, S5.7, TAPA1, TSPAN28
  • Links
    NCBI Gene ID: 975
    neXtProt AC: NX_P60033

  • Chr Location
    11p15.5; chr11:2376177-2397419 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CD81 associations

Human Disease Mouse Models
       Immunodeficiency, Common Variable, 6; CVID6   OMIM: 613496
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 3 alleles in 7 genetic backgrounds
    8 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit altered antibody responses to specific antigens, reductions in peritoneal B-1 cell numbers and IL4 production, increased plasma IgA and IgM levels, and enlarged brains with more astrocytes and microglia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031887 VEGA Gene Model | MGI Sequence Detail 15196 C57BL/6J ±  kb
transcript OTTMUST00000079053 VEGA | MGI Sequence Detail 1533 Not Applicable  
polypeptide OTTMUSP00000042126 VEGA | MGI Sequence Detail 236 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    63 from dbSNP Build 137
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 380
    Genomic 24
    cDNA 349
    Primer pair 5
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-14716, MGD-MRK-14717, MGI:98485
References
more
  • Summaries
    All 99
    Developmental Gene Expression 20
    Gene Ontology 7
    Phenotypes 31
  • Earliest
    J:10529 Bastian H, et al., A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
  • Latest
    J:226789 Vences-Catalan F, et al., Tetraspanin CD81 Promotes Tumor Growth and Metastasis by Modulating the Functions of T Regulatory and Myeloid-Derived Suppressor Cells. Cancer Res. 2015 Nov 1;75(21):4517-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory