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Cd81
Gene Detail
Symbol

Name
ID
Cd81
CD81 antigen
MGI:1096398
Synonyms
Tapa1, Tapa-1, Tspan28
Feature Type
protein coding gene
Genetic Map
Chromosome 7
88.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr7:143052739-143067934 bp, + strand
From VEGA annotation of GRCm38

  15196 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20915  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: CD81
Protein SuperFamily: tetraspanin
Gene Tree: Cd81

Human
homologs
CD81, CD81 molecule
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 975
neXtProt AC: NX_P60033

Human Synonyms: CVID6, S5.7, TAPA1, TSPAN28

Human Chr (Location): 11p15.5; chr11:2376177-2397419 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CD81

Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(18) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit altered antibody responses to specific antigens, reductions in peritoneal B-1 cell numbers and IL4 production, increased plasma IgA and IgM levels, and enlarged brains with more astrocytes and microglia.
 
Interactions
Cd81 interacts with 120 markers (Mir7-1, Mir15a, Mir24-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (20 records)
Data Summary: Results (245)    Tissues (127)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 164
RT-PCR 81
cDNA source data(348)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cd81 ; ZFIN cd81b    NEW 
Molecular
reagents
All nucleic(378) Genomic(24) cDNA(349) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000031887 (Evidence)
Ensembl Gene Model ENSMUSG00000037706 (Evidence)
Entrez Gene 12520 (Evidence)
UniGene 806
DFCI TC1573413
DoTS DT.536922, DT.97397252
NIA Mouse Gene Index U008989
Consensus CDS Project CCDS22038.1
International Mouse Phenotyping Consortium Status Cd81
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031887 VEGA Gene Model | MGI Sequence Detail 15196 C57BL/6J ±  kb
transcript OTTMUST00000079053 VEGA | MGI Sequence Detail 1533 Not Applicable 
polypeptide OTTMUSP00000042126 VEGA | MGI Sequence Detail 236 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(63 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000301 Tetraspanin
InterPro IPR018503 Tetraspanin, conserved site
InterPro IPR008952 Tetraspanin, EC2 domain
InterPro IPR018499 Tetraspanin/Peripherin
Protein Ontology PR:000005176 CD81 molecule
References
(Earliest) J:10529 Bastian H, et al., A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
(Latest) J:213512 Werber M, et al., The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo. Development. 2014 Jun;141(11):2325-30
All references(99)
Other
accession IDs
MGD-MRK-14716, MGD-MRK-14717, MGI:98485

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory