Cd81
Gene Detail

Symbol Name ID

Cd81 CD81 antigen MGI:1096398

Synonyms

Tapa1, Tapa-1, Tspan28

Feature Type

protein coding gene

Genetic Map

Chromosome 7

88.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)

Sequence Map

Chr7:143052739-143067934 bp, + strand From VEGA annotation of GRCm38   15196 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20915  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: tetraspanin
Gene Tree: Cd81

Human homologs

Human Homolog		CD81, CD81 molecule
NCBI Gene ID		975
neXtProt AC		NX_P60033
Human Synonyms		CVID6, S5.7, TAPA1, TSPAN28
Human Chr (Location)		11p15.5; chr11:2398547-2418649 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CD81

Alleles and phenotypes

All alleles(23) : Targeted(5) Gene trapped(18)
 

Homozygotes for targeted null mutations exhibit altered antibody responses to specific antigens, reductions in peritoneal B-1 cell numbers and IL4 production, increased plasma IgA and IgM levels, and enlarged brains with more astrocytes and microglia.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	activation of MAPK activity, phosphatidylinositol biosynthetic process, ...
Component	apical plasma membrane, immunological synapse, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (245)    Tissues (126)    Images (33)
Theiler Stages: 9, 11, 13, 15, 17, 20, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	164
RT-PCR	81

cDNA source data(345)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(375) Genomic(24) cDNA(346) Primer pair(4) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000031887 (Evidence)
Ensembl Gene Model	ENSMUSG00000037706 (Evidence)
Entrez Gene	12520 (Evidence)
UniGene	806
DFCI	TC1573413
DoTS	DT.536922, DT.97397252
NIA Mouse Gene Index	U008989
Consensus CDS Project	CCDS22038.1
International Mouse Knockout Project Status	Cd81

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031887	VEGA Gene Model | MGI Sequence Detail	15196	C57BL/6J
transcript	OTTMUST00000079053	VEGA | MGI Sequence Detail	1533	Not Applicable
polypeptide	OTTMUSP00000042126	VEGA | MGI Sequence Detail	236	Not Applicable

All sequences(42) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(4 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000301	Tetraspanin
InterPro	IPR018503	Tetraspanin, conserved site
InterPro	IPR008952	Tetraspanin, EC2 domain
InterPro	IPR018499	Tetraspanin/Peripherin
Protein Ontology	PR:000005176	CD81 molecule

References

(Earliest) J:10529 Bastian H, et al., A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
(Latest) J:193860 Iwasaki T, et al., Deletion of tetraspanin CD9 diminishes lymphangiogenesis in vivo and in vitro. J Biol Chem. 2013 Jan 25;288(4):2118-31
All references(97)

Other accession IDs

MGD-MRK-14716, MGD-MRK-14717, MGI:98485