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Cd81
Gene Detail
 Symbol
Name
ID
Cd81
CD81 antigen
MGI:1096398
Synonyms Tapa1, Tapa-1, Tspan28
Feature Type protein coding gene
Genetic Map
Chromosome 7
88.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr7:143052739-143067934 bp, + strand
From VEGA annotation of GRCm38

  15196 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20915  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: tetraspanin
Gene Tree: Cd81

Human
homologs
Human Homolog CD81, CD81 molecule
NCBI Gene ID 975
neXtProt AC  NX_P60033
Human Synonyms  CVID6, S5.7, TAPA1, TSPAN28
Human Chr (Location)  11p15.5; chr11:2376161-2397419 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CD81
Alleles
and
phenotypes
All alleles(23) : Targeted(5) Gene trapped(18)
 
Homozygotes for targeted null mutations exhibit altered antibody responses to specific antigens, reductions in peritoneal B-1 cell numbers and IL4 production, increased plasma IgA and IgM levels, and enlarged brains with more astrocytes and microglia.
 
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process activation of MAPK activity, phosphatidylinositol biosynthetic process, ...
Component apical plasma membrane, extracellular vesicular exosome, ...
Function MHC class II protein complex binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (245)    Tissues (126)    Images (33)
Theiler Stages: 9, 11, 13, 15, 17, 20, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 164
RT-PCR 81
cDNA source data(348)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(378) Genomic(24) cDNA(349) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000031887 (Evidence)
Ensembl Gene ModelENSMUSG00000037706 (Evidence)
Entrez Gene12520 (Evidence)
UniGene806
DFCITC1573413
DoTSDT.536922, DT.97397252
NIA Mouse Gene IndexU008989
Consensus CDS ProjectCCDS22038.1
International Mouse Knockout Project StatusCd81
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031887 VEGA Gene Model | MGI Sequence Detail 15196 C57BL/6J ±  kb
transcript OTTMUST00000079053 VEGA | MGI Sequence Detail 1533 Not Applicable 
polypeptide OTTMUSP00000042126 VEGA | MGI Sequence Detail 236 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(63 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000301 Tetraspanin
InterPro IPR018503 Tetraspanin, conserved site
InterPro IPR008952 Tetraspanin, EC2 domain
InterPro IPR018499 Tetraspanin/Peripherin
Protein Ontology PR:000005176 CD81 molecule
References (Earliest) J:10529 Bastian H, et al., A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
(Latest) J:197437 Bhave VS, et al., Regulation of liver growth by glypican 3, CD81, hedgehog, and hhex. Am J Pathol. 2013 Jul;183(1):153-9
All references(99)
Other
accession IDs
MGD-MRK-14716, MGD-MRK-14717, MGI:98485

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory